公开(公告)号：US09182391B2

公开(公告)日：2015-11-10

申请号：US12936783

申请日：2009-04-21

申请人： Hidenori Takagi

发明人： Hidenori Takagi

IPC分类号： G01N33/543

CPC分类号： G01N33/54353 ,  G01N33/54313

摘要： The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivity; an immunoturbidimetric assay using the same; and a method of producing thereof. A method of producing an insoluble carrier particle of the present invention is a method of producing an insoluble carrier particle carrying an antibody or an antigen on a particle surface thereof. The method includes a sensitization reaction processes in which the antibody or the antigen is brought into contact with the insoluble carrier particle in the presence of an amino acid with a charged polar side chain in a sensitization reaction solution. The insoluble carrier particles obtained by the producing method of the present invention show favorable dispersibility because nonspecific aggregation is suppressed. As can be seen from Examples 1-1 to 1-4 in FIG. 3, when the insoluble carrier particles are applied to measurement by an immunoturbidimetric assay, a wide measurement concentration range and high measurement sensitivity can be achieved.

摘要翻译： 本发明提供一种能够抑制非特异性聚集的测定试剂，即使被携带抗体的量增加，能够在测定灵敏度高的测定浓度范围内进行测定。 使用其的免疫比浊法测定; 及其制造方法。 制备本发明的不溶性载体颗粒的方法是在其颗粒表面上生产携带抗体或抗原的不溶性载体颗粒的方法。 该方法包括致敏反应过程，其中抗体或抗原在致敏反应溶液中带有带极性侧链的氨基酸存在下与不溶性载体颗粒接触。 通过本发明的制造方法获得的不溶性载体颗粒由于非特异性聚集被抑制而显示出良好的分散性。 从图1的实施例1-1〜1-4可以看出， 如图3所示，当通过免疫比浊法测定不溶性载体颗粒时，可以获得宽的测量浓度范围和高的测量灵敏度。

公开(公告)号：US20110027915A1

公开(公告)日：2011-02-03

申请号：US12936783

申请日：2009-04-21

申请人： Hidenori Takagi

发明人： Hidenori Takagi

IPC分类号： G01N33/544 ,  C07K17/02 ,  G01N30/00

CPC分类号： G01N33/54353 ,  G01N33/54313

摘要： The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivity; an immunoturbidimetric assay using the same; and a method of producing thereof. A method of producing an insoluble carrier particle of the present invention is a method of producing an insoluble carrier particle carrying an antibody or an antigen on a particle surface thereof. The method includes a sensitization reaction processes in which the antibody or the antigen is brought into contact with the insoluble carrier particle in the presence of an amino acid with a charged polar side chain in a sensitization reaction solution. The insoluble carrier particles obtained by the producing method of the present invention show favorable dispersibility because nonspecific aggregation is suppressed. As can be seen from Examples 1-1 to 1-4 in FIG. 3, when the insoluble carrier particles are applied to measurement by an immunoturbidimetric assay, a wide measurement concentration range and high measurement sensitivity can be achieved.

摘要翻译： 本发明提供一种能够抑制非特异性聚集的测定试剂，即使被携带抗体的量增加，能够在测定灵敏度高的测定浓度范围内进行测定。 使用其的免疫比浊法测定; 及其制造方法。 制备本发明的不溶性载体颗粒的方法是在其颗粒表面上生产携带抗体或抗原的不溶性载体颗粒的方法。 该方法包括致敏反应过程，其中抗体或抗原在致敏反应溶液中带有带极性侧链的氨基酸存在下与不溶性载体颗粒接触。 通过本发明的制造方法获得的不溶性载体颗粒由于非特异性聚集被抑制而显示出良好的分散性。 从图1的实施例1-1〜1-4可以看出， 如图3所示，当通过免疫比浊法测定不溶性载体颗粒时，可以获得宽的测量浓度范围和高的测量灵敏度。

公开(公告)号：US07709922B2

公开(公告)日：2010-05-04

申请号：US10594341

申请日：2005-03-17

申请人： Hidenori Takagi ,  Yoshinobu Nakamura ,  Kouhei Fujiwara

发明人： Hidenori Takagi ,  Yoshinobu Nakamura ,  Kouhei Fujiwara

IPC分类号： H01L31/058

CPC分类号： H01C7/008 ,  H01C7/021 ,  H01C7/041

摘要： A thermistor device having a high-speed response to temperature and a large ON/OFF ratio at the operating temperature. The thermistor device comprises a first layer of a first material having a positive temperature coefficient of resistance and a second layer of a second material having a semiconductivity and formed directly on the first layer. As the first material changes from conductive to a semiconductive or an insulative at or near the transition temperature TM-I, the interface between the first and second layer changes to a pn junction.

摘要翻译： 一种在工作温度下具有高温响应和ON / OFF比大的热敏电阻器件。 热敏电阻器件包括具有正温度系数电阻的第一材料的第一层和具有半导电性并直接形成在第一层上的第二材料的第二层。 由于第一材料在转变温度TM-1处或接近转变温度TM-1时从导电变为半导体或绝缘，所以第一和第二层之间的界面改变为pn结。

公开(公告)号：US09645154B2

公开(公告)日：2017-05-09

申请号：US13995585

申请日：2011-12-22

申请人： Hidenori Takagi ,  Hiroshi Ito ,  Masahiro Kozuka

发明人： Hidenori Takagi ,  Hiroshi Ito ,  Masahiro Kozuka

IPC分类号： G01N33/72 ,  G01N33/58 ,  G01N33/574

CPC分类号： G01N33/582 ,  G01N33/574 ,  G01N33/72

摘要： A method for detecting a cancer cell, including: contacting in vitro a peripheral blood-containing sample including test cells and a labeling substance; allowing the test cells to incorporate the labeling substance to label the test cells; and detecting, as a cancer cell, a cell showing a higher degree of labeling with the labeling substance than that shown by a normal cell in the peripheral blood-containing sample.

公开(公告)号：US09260491B2

公开(公告)日：2016-02-16

申请号：US13504636

申请日：2010-10-28

申请人： Fumio Takaiwa ,  Hidenori Takagi ,  Yuhya Wakasa ,  Yuji Fujii ,  Tomotaka Shinya ,  Saori Kasahara

发明人： Fumio Takaiwa ,  Hidenori Takagi ,  Yuhya Wakasa ,  Yuji Fujii ,  Tomotaka Shinya ,  Saori Kasahara

IPC分类号： A61K39/36 ,  C07K14/415 ,  A61K38/00

CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/36

摘要： It is an object of the present invention to provide a protein that can successfully treats almost all patients with cedar pollinosis and can be ingested as a food. That is, the present invention provides a protein comprising an amino acid sequence represented by SEQ ID NO:1 or comprising an amino acid sequence having a mutation(s) in said amino acid sequence, and having an immunogenicity of a cedar pollen; a polynucleotide encoding said protein; a vector comprising said polynucleotide; a transformant comprising said polynucleotide or said vector; and intended uses of said protein, said polynucleotide, and said transformant.

摘要翻译： 本发明的目的是提供一种可以成功地治疗几乎所有患有雪松花粉症的患者的蛋白质，并且可以作为食物摄取。 也就是说，本发明提供了包含由SEQ ID NO：1所示的氨基酸序列或包含在所述氨基酸序列中具有突变并具有雪松花粉免疫原性的氨基酸序列的蛋白质的蛋白质。 编码所述蛋白质的多核苷酸; 包含所述多核苷酸的载体; 包含所述多核苷酸或所述载体的转化体; 和所述蛋白质，所述多核苷酸和所述转化体的预期用途。

公开(公告)号：US20140050229A1

公开(公告)日：2014-02-20

申请号：US13819567

申请日：2012-03-08

申请人： Toshihito Kon ,  Daigo Takaoka ,  Fumiya Akamatsu ,  Hidenori Takagi

发明人： Toshihito Kon ,  Daigo Takaoka ,  Fumiya Akamatsu ,  Hidenori Takagi

IPC分类号： H04L29/06 ,  H04L29/08 ,  G05B15/02

CPC分类号： H04L69/08 ,  G05B15/02 ,  H04L12/2823 ,  H04L67/12

摘要： Operations of a building facility monitoring device and an IP network monitoring device are coordinated with each other. In a connection system of a building facility device managing system, when a status of the IP network monitoring device is changed, a monitoring-device-status managing unit 301 provides parameter information unique for a BACnet protocol to the changed status and stores it. If the status is not an operation command, a coordinated-packet-generation transmitting/receiving unit 302 generates a packet of the BACnet protocol based on a status and parameter information of a specific IP network monitoring device to transmit it to a building facility device managing system 103. If the status is the operation command, it acquires a status and parameter information of the specific IP network monitoring device from a management database 401, and generates a packet of the BACnet protocol based on the status and the parameter information to transmit it to the building facility device managing system 103.

摘要翻译： 建筑设施监控装置和IP网络监控装置的操作相互协调。 在建筑设备设备管理系统的连接系统中，当IP网络监控设备的状态改变时，监控设备状态管理单元301将BACnet协议唯一的参数信息提供给改变的状态并将其存储。 如果状态不是操作命令，协调分组生成发送/接收单元302基于特定IP网络监视设备的状态和参数信息生成BACnet协议的分组，以将其发送到建筑设备设备管理 系统103.如果状态是操作命令，则从管理数据库401获取特定IP网络监视设备的状态和参数信息，并且基于状态和参数信息生成BACnet协议的分组以发送它 到建筑设备设备管理系统103。

公开(公告)号：US20130288273A1

公开(公告)日：2013-10-31

申请号：US13995585

申请日：2011-12-22

申请人： Hidenori Takagi ,  Hiroshi Ito ,  Masahiro Kozuka

发明人： Hidenori Takagi ,  Hiroshi Ito ,  Masahiro Kozuka

IPC分类号： G01N33/58

CPC分类号： G01N33/582 ,  G01N33/574 ,  G01N33/72

摘要： A method for detecting a cancer cell, including: contacting in vitro a peripheral blood-containing sample including test cells and a labeling substance; allowing the test cells to incorporate the labeling substance to label the test cells; and detecting, as a cancer cell, a cell showing a higher degree of labeling with the labeling substance than that shown by a normal cell in the peripheral blood-containing sample.

摘要翻译： 一种检测癌细胞的方法，包括：体外接触包含测试细胞和标记物质的外周血样品; 允许测试细胞掺入标记物质以标记测试细胞; 并且作为癌细胞，检测与外周含血样品中的正常细胞相比，标记物质的标记物的标记度高的细胞。

公开(公告)号：US08105704B2

公开(公告)日：2012-01-31

申请号：US11661318

申请日：2005-08-30

申请人： Hidenori Takagi ,  Tomohiro Takayama

发明人： Hidenori Takagi ,  Tomohiro Takayama

IPC分类号： G11B5/33

CPC分类号： H01F10/18 ,  C01G49/12 ,  C01P2002/30 ,  C01P2004/42 ,  G11B5/02 ,  G11B5/70626 ,  G11B11/10506 ,  G11B11/10517 ,  G11B11/10582 ,  G11B11/10584 ,  G11B11/10586 ,  G11B2005/0002 ,  G11B2005/0021 ,  H01F10/14 ,  H01F41/14 ,  H01F41/22 ,  Y10T428/115

摘要： A memory is provided that is improved in cost, life, energy consumption and recording density over existing optical disks and hard disks and operates under novel principles, as well as its manufacturing method. A nonvolatile phase change magnetic memory comprises a substrate and a film loaded on the substrate, which film is of a crystalline transition metal chalcogenide compound that in composition is deficient in transition metal from its stoichiometric ratio composition and expressed by formula: AyX where A is a transition metal, X is a chalcogen element and 0

摘要翻译： 提供了一种存储器，其在现有光盘和硬盘上的成本，寿命，能量消耗和记录密度方面得到改善，并且以新颖的原理以及其制造方法运行。 非易失性相变磁存储器包括衬底和负载在衬底上的膜，该膜是结晶过渡金属硫属化物化合物，其组成是从化学计量比组成得到的过渡金属不足，由下式表示：其中A是 过渡金属，X是硫族元素，0

公开(公告)号：US20070136896A1

公开(公告)日：2007-06-14

申请号：US10554308

申请日：2004-04-23

申请人： Fumio Takaiwa ,  Hidenori Takagi

发明人： Fumio Takaiwa ,  Hidenori Takagi

IPC分类号： A01H1/00 ,  C12N15/82 ,  C12N5/04 ,  C07K14/705 ,  C07K14/415

CPC分类号： C12N15/8258 ,  A23L7/10 ,  A23L7/196 ,  A23L19/00 ,  A23V2002/00 ,  A61K36/899 ,  A61K39/36 ,  C07K14/415 ,  A23V2200/30 ,  A23V2200/304

摘要： Disclosed herein are techniques for accumulating a human T-cell epitope in rice albumen, particularly a method of directly accumulating a T-cell epitope-linked peptide, such as 7 Crp, in rice seeds and a method of inserting 7 Crp into a variable region of glutelin, the major storage protein of rice, to express and accumulate 7 Crp as a part of the glutelin storage protein. Rice producing the T-cell epitope-linked peptide developed in accordance with the present invention is expected to function as an edible vaccine against Japanese cedar pollinosis.

摘要翻译： 本文公开了用于在水稻种子中积累人T细胞表位的技术，特别是在水稻种子中直接积累T细胞表位连接的肽，例如7Crp的方法，以及将7Crp插入可变区 的谷蛋白，水稻的主要储存蛋白，以表达和积累7 Crp作为谷蛋白储存蛋白的一部分。 产生根据本发明开发的T细胞表位连锁肽的水稻预期可用作针对日本松柏花粉的可食用疫苗。

公开(公告)号：US20060045779A1

公开(公告)日：2006-03-02

申请号：US11212567

申请日：2005-08-29

申请人： Nao Takeshita ,  Chieko Terakura ,  Hidenori Takagi ,  Yoshinori Tokura

发明人： Nao Takeshita ,  Chieko Terakura ,  Hidenori Takagi ,  Yoshinori Tokura

IPC分类号： A61M1/00

CPC分类号： B01J3/04 ,  G01N3/12

摘要： Disclosed is a high-pressure generation apparatus, which comprises a pair of columnar-shaped anvils disposed in opposed relation to one another to define a pressure-generating space therebetween. The anvils are adapted to be applied with a load therebetween to generate a high pressure in the pressure-generating space. Each of the anvils has a top portion formed in an approximately circular truncated cone shape, and the top portion has a central region formed with a depression having a side surface which extends obliquely outward. The high-pressure generation apparatus also includes a cylindrical capsule disposed in a central area of the pressure-generating space, and a laminated member formed by alternately laminating a doughnut-shaped metallic thin plate and a doughnut-shaped insulating member along the outer periphery of the capsule. The improved shape of the depression makes it possible to significantly reduce damages of the components. In addition, the laminated member formed of the metallic thin plate and the insulating member originally used for sealing the pressure-generating space makes it possible to generate a higher pressure.