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18 条记录 (耗时 0.031 秒)

    Steroid compounds and process of preparing the same
    1.
    发明授权
    Steroid compounds and process of preparing the same 失效
    类固醇化合物及其制备方法

    公开(公告)号：US4874855A

    公开(公告)日：1989-10-17

    申请号：US189849

    申请日：1988-05-03

    申请人： Hidetsugu Takagaki ,  Masayoshi Abe ,  Michihiro Watanabe ,  Kazuyuki Takeuchi ,  Shigenori Nakanishi ,  Yuuko Nakata ,  Keiji Yamazaki

    发明人： Hidetsugu Takagaki ,  Masayoshi Abe ,  Michihiro Watanabe ,  Kazuyuki Takeuchi ,  Shigenori Nakanishi ,  Yuuko Nakata ,  Keiji Yamazaki

    IPC分类号： C07J5/00 ,  C07J51/00

    CPC分类号： C07J5/0053 ,  C07J51/00

    摘要： Disclosed are steroid compounds represented by general formula (I) ##STR1## wherein X and W together as >W-X represent a carbonyl group (>C.dbd.O) or a hydroxymethylene group (>CH(OH)), the hydroxy moiety of the hydroxymethylene group being of .beta.-arrangement, and OR.sup.1 and OR.sup.2 independently represent an ester residue, and Y and Z together as --Y--Z-- represent a --(PpSe)CH--CH.sub.2 -- group where Pp represent a phenyl group or a 2-pyridyl group, or Y and Z each represent an ethenylene group or a 1-bromoethylene group.Also disclosed is a process of preparing the compound (I) includes reacting 6.beta., 9.alpha.-difluoro-5.alpha.,17.alpha.,21-trihydroxypregna-3,11,20-trione-17,21-diesters or 6.beta.,9.alpha.-difluoro-5.alpha.,11.beta.,17.alpha.,21-tetrahydroxypregna-3,20-dione-17,21-diesters as starting compound with an organic selenenyl halide selected from the group consisting of 2-pyridylselenenyl chloride, 2-pyridylselenenyl bromide, phenylselenenyl chlolride and phenylselenenyl bromide.Further disclosed is a process of preparing 2-bromo-6.beta.,9.alpha.-difluoro-11.beta.,17.alpha.,21-trihydroxy-1,4-pregnadien-3,20-di-one-17,21-diester represented by general formula (VII) ##STR2## wherein OR.sup.1 and OR.sup.2 independently represent an ester residue, which comprises reacting with hydrogen chloride, or with thionyl chloride in the presence of a basic substance, the compound (V), and optionally reducing with a reducing agent when >W-X represents a carbonyl group.

    Process for preparation of steroids
    2.
    发明授权
    Process for preparation of steroids 失效
    类固醇的制备方法

    公开(公告)号：US4525303A

    公开(公告)日：1985-06-25

    申请号：US505292

    申请日：1983-06-17

    申请人： Hidetsugu Takagaki ,  Shigenori Nakanishi ,  Yasuyuki Tanaka ,  Michihiro Watanabe ,  Yoriko Yonehara

    发明人： Hidetsugu Takagaki ,  Shigenori Nakanishi ,  Yasuyuki Tanaka ,  Michihiro Watanabe ,  Yoriko Yonehara

    IPC分类号： C07J5/00 ,  C07J21/00 ,  C07J71/00

    CPC分类号： C07J5/0053 ,  C07J21/006 ,  C07J71/001 ,  C07J71/0015

    摘要： A novel process for preparing a steroid of the following formula (to be referred to as compound .circle.13 ) is provided. ##STR1## This compound is known to have marked anti-inflammatory and anti-rheumatoid arthritic activity with very much reduced side effects on humans, such as weight loss, sodium retention, potassium loss and adrenal and pituitary inhibition which are observed in many steroids. The process is characterized in that starting from hydrocortisone, it can produce the desired compound .circle.13 at low cost and that it goes through the following two novel compounds (I) and (II) as intermediates. ##STR2## In the above formulae, >W--X represents >C.dbd.O or >CH--OH, >Y--Z-- represents >C.dbd.CH-- or ##STR3## Q represents a hydrogen or bromine atom, and OR.sup.1 and OR.sup.2 are identical or different and each represents an acyloxy group or a sulfuric or phosphoric acid ester residue.

    摘要翻译： 提供了制备下式的类固醇的新方法（以下称为化合物＆Cir＆13）。 已知这种化合物具有显着的抗炎和抗类风湿关节炎活性，对人类的副作用大大减少，例如在许多类固醇中观察到的体重减轻，钠滞留，钾损失以及肾上腺和垂体抑制。 该方法的特征在于，从氢化可的松开始，它可以以低成本生产所需化合物＆lt; 13＆13，并且通过以下两种新化合物（I）和（II）作为中间体。 （II）在上式中，WX表示C = O或> CH-OH，YZ-表示C = CH-或Q表示氢或溴原子 OR 1和OR 2相同或不同，各自表示酰氧基或硫酸或磷酸酯残基。

    Method and apparatus for correcting an image signal
    3.
    发明授权
    Method and apparatus for correcting an image signal 失效
    用于校正图像信号的方法和装置

    公开(公告)号：US5130822A

    公开(公告)日：1992-07-14

    申请号：US481626

    申请日：1990-02-20

    申请人： Tatsuya Nagata ,  Michihiro Watanabe ,  Takehiko Yamada ,  Eiichi Hara

    发明人： Tatsuya Nagata ,  Michihiro Watanabe ,  Takehiko Yamada ,  Eiichi Hara

    IPC分类号： H04N1/403

    CPC分类号： H04N1/403

    摘要： A digital signal is provided by correcting image signal distortions contained in an image signal outputted from an elongated direct contact type image sensor in an image reader such as a facsimile device, which image sensor reads patterns on a document in contact with the document. The image signal distortions of the sensor output are so-called shading distortions due to sensitivity distribution of sensor elements or distribution of light from light sources onto the document. Signal distortions are corrected from both a white signal outputted from the sensor when a white document is read and a black signal outputted when a black document is read. The white signal and the black signal are stored and reproduced to generate a reference signal which is obtained by dividing the voltage range across both the signals at a predetermined ratio. The digital signal is obtained by comparing the sensor output with the reference signal. If necessary, a pseudo-black signal may be produced by dividing the voltage of the white signal.

    摘要翻译： 通过校正图像传感器中的图像读取器（例如传真装置）中从细长直接接触型图像传感器输出的图像信号中包含的图像信号失真来提供数字信号，该图像传感器读取与文档接触的文档上的图案。 传感器输出的图像信号失真是由于传感器元件的灵敏度分布或来自光源的光分布到文档上而引起的所谓阴影失真。 当读取白色文档时读出从传感器输出的白色信号和读取黑色文档时输出黑色信号的信号失真。 白色信号和黑色信号被存储和再现以产生参考信号，该参考信号是通过以预定的比例将两个信号的电压范围分开而获得的。 通过将传感器输出与参考信号进行比较来获得数字信号。 如果需要，可以通过划分白色信号的电压来产生伪黑色信号。

    Measuring method and apparatus of thin film thickness
    5.
    发明申请
    Measuring method and apparatus of thin film thickness 审中-公开
    薄膜厚度的测量方法和装置

    公开(公告)号：US20050073323A1

    公开(公告)日：2005-04-07

    申请号：US10902132

    申请日：2004-07-30

    申请人： Ryuji Kohno ,  Tatsuya Nagata ,  Naoki Watase ,  Michihiro Watanabe

    发明人： Ryuji Kohno ,  Tatsuya Nagata ,  Naoki Watase ,  Michihiro Watanabe

    IPC分类号： G01B7/06 ,  G01R27/26 ,  H01L21/66

    CPC分类号： G01R27/2605

    摘要： In an apparatus for measuring thickness of a thin film, which is formed through a conductor, preventing the measurement from an error due to the curve or bend on a substrate surface or a moving surface of a stage, but without necessity of a large-scaled facility, an electric filed is applied between a probe 10 and a stage 8, so as to obtain an electrostatic capacitance of the substrate 3, an electrostatic capacitance of an insulating film, which is formed between the substrate 3, and an electrostatic capacitance defined starting from the substrate 3 to the thin film 4. The electrostatic capacitance between the substrate 3 and the thin film 4 is measured at plural numbers of places covering over the entire surface of the thin film 4. The probe 10 is so supported that the contact load “P” comes to be constant, by the probe 10 onto the thin film 4. A contact area of the probe 10 between the thin film 4 is calculated out through a predetermined equation, assuming the load “P” is constant. From respective electrostatic capacitances and the contact area measured, a distribution of thickness of the thin film 4 over the entire area thereof.

    摘要翻译： 在用于测量通过导体形成的薄膜厚度的装置中，防止测量由于基板表面或台的移动表面上的曲线或弯曲引起的误差，而不需要大尺寸 在探针10和载物台8之间施加电场，以获得基板3的静电电容，形成在基板3之间的绝缘膜的静电电容与开始定义的静电电容 从基板3到薄膜4.在覆盖在薄膜4的整个表面上的多个位置处测量基板3和薄膜4之间的静电电容。探针10被支撑为接触负载 假定负载“P”是恒定的，则通过探针10将薄膜4固定在薄膜4上的探针10的接触区域。 从相应的静电电容和测量的接触面积，薄膜4的整个面积的厚度分布。

    Direct-contact-type image sensor and image sensor assembly
    10.
    发明授权
    Direct-contact-type image sensor and image sensor assembly 失效
    直接接触式图像传感器和图像传感器组件

    公开(公告)号：US4940888A

    公开(公告)日：1990-07-10

    申请号：US321881

    申请日：1989-03-10

    申请人： Tatsuya Nagata ,  Takehiko Yamada ,  Eiichi Hara ,  Michihiro Watanabe

    发明人： Tatsuya Nagata ,  Takehiko Yamada ,  Eiichi Hara ,  Michihiro Watanabe

    IPC分类号： H04N1/028 ,  H01L21/66 ,  H01L27/146 ,  H04N1/031

    CPC分类号： H04N1/0316 ,  H04N1/0313

    摘要： In a contact-type image sensor for use in a facsimile equipment or the like, the surface of the sensor is provided with a transparent film which is electroconductive and of which the surface that is in contact with the sensor elements is formed as a roughened surface capable of scattering light. By virtue of the provision of this film, static electricity generated during the running of the original is prevented from causing fluctuations in the sensor output voltage. In addition, light reflected by the surface of the transparent film is prevented from becoming directly incident on the sensor elements and, hence, from causing abnormal increases in the sensor output.

    摘要翻译： 在用于传真设备等的接触式图像传感器中，传感器的表面设置有导电性的透明膜，并且与传感器元件接触的表面形成为粗糙表面 能散射光。 由于提供这种胶片，防止在原稿运行期间产生的静电导致传感器输出电压的波动。 此外，防止透明膜的表面反射的光直接入射到传感器元件上，从而导致传感器输出的异常增加。