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公开(公告)号:US20100152261A1
公开(公告)日:2010-06-17
申请号:US11996922
申请日:2006-07-25
申请人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
发明人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
IPC分类号: A61K31/4196 , A61K31/4164 , C07D249/08 , C07D233/66 , C07D233/56 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/00 , A61P25/00
CPC分类号: C07D233/56 , C07D233/18 , C07D233/60 , C07D233/61 , C07D249/08 , C07D407/06
摘要: A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
摘要翻译: 由以下通式(I)表示的含氮杂环衍生物或其水合物或溶剂化物,其对毒蕈碱性M3受体具有选择性拮抗作用并引起心脏副作用降低,因此是安全的,并且具有优异的药理功效 以及甚至通过吸入给药延长的作用,以及包含该化合物和药学上可接受的载体的药物组合物。
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公开(公告)号:US20100041643A1
公开(公告)日:2010-02-18
申请号:US11916015
申请日:2006-05-30
申请人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号: A61K31/551 , C07D495/14
CPC分类号: C07D495/14
摘要: [Solving means] A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. [Effect]Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译: [解决方案]下述式(I)的噻吩并三唑并氮杂化合物是含有该化合物作为有效成分的药剂,以及噻吩并三唑并氮杂化合物的制造中间体和制造方法。 [效果]由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用,因此可用于预防或抑制移植器官或骨髓等中的排斥反应,以及预防或治疗自身免疫性疾病或 过敏性疾病
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公开(公告)号:US08044042B2
公开(公告)日:2011-10-25
申请号:US11916015
申请日:2006-05-30
申请人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号: A61P1/04 , A61P3/10 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/14 , A61P29/00 , A61P37/00 , A61P43/00 , A61K31/551 , C07D495/14
CPC分类号: C07D495/14
摘要: A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译: 下式(I)的噻吩并三唑并噻嗪类化合物是含有该化合物作为活性成分的药剂,以及噻吩并三唑并噻吩类化合物的制造中间体和制造方法。 由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用,因此可用于预防或抑制移植器官或骨髓等中的排斥反应,以及预防或治疗自身免疫疾病或过敏性疾病。
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公开(公告)号:US09150555B2
公开(公告)日:2015-10-06
申请号:US13879475
申请日:2011-10-13
申请人: Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
发明人: Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
IPC分类号: A61K31/47 , C07D211/14 , C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
CPC分类号: C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
摘要: The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.
摘要翻译: 本发明涉及新型酰胺衍生物。 更具体地说,本发明提供可用作疾病的预防或治疗剂的药剂,其依赖于来自T细胞的细胞因子的产生,并且其包含酰胺衍生物或其药理学上可接受的盐或衍生物的溶剂合物或 药理学上可接受的盐作为活性成分。 本发明提供通式(I)表示的酰胺衍生物或其药理学上可接受的盐,或其衍生物或药理学上可接受的盐的溶剂合物。
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公开(公告)号:US20130211075A1
公开(公告)日:2013-08-15
申请号:US13879475
申请日:2011-10-13
申请人: Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
发明人: Hiroyuki Ushio , Maiko Hamada , Masayuki Watanabe , Atsushi Numata , Naoto Fujie , Tooru Takashima , Hiroyuki Furukawa , Junki Ando
IPC分类号: C07D405/14 , C07D401/12 , C07D401/14
CPC分类号: C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D495/04
摘要: The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.
摘要翻译: 本发明涉及新型酰胺衍生物。 更具体地说,本发明提供可用作疾病的预防或治疗剂的药剂,其依赖于来自T细胞的细胞因子的产生,并且其包含酰胺衍生物或其药理学上可接受的盐或衍生物的溶剂合物或 药理学上可接受的盐作为活性成分。 本发明提供通式(I)表示的酰胺衍生物或其药理学上可接受的盐,或其衍生物或药理学上可接受的盐的溶剂合物。
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