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公开(公告)号:US20100041643A1
公开(公告)日:2010-02-18
申请号:US11916015
申请日:2006-05-30
申请人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号: A61K31/551 , C07D495/14
CPC分类号: C07D495/14
摘要: [Solving means] A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. [Effect]Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译: [解决方案]下述式(I)的噻吩并三唑并氮杂化合物是含有该化合物作为有效成分的药剂,以及噻吩并三唑并氮杂化合物的制造中间体和制造方法。 [效果]由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用,因此可用于预防或抑制移植器官或骨髓等中的排斥反应,以及预防或治疗自身免疫性疾病或 过敏性疾病
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公开(公告)号:US08044042B2
公开(公告)日:2011-10-25
申请号:US11916015
申请日:2006-05-30
申请人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
发明人: Kunitomo Adachi , Hidemasa Hikawa , Maiko Hamada , Jun-ichi Endoh , Seigo Ishibuchi , Naoto Fujie , Minoru Tanaka , Kunio Sugahara , Kouichi Oshita , Meguru Murata
IPC分类号: A61P1/04 , A61P3/10 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/14 , A61P29/00 , A61P37/00 , A61P43/00 , A61K31/551 , C07D495/14
CPC分类号: C07D495/14
摘要: A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.
摘要翻译: 下式(I)的噻吩并三唑并噻嗪类化合物是含有该化合物作为活性成分的药剂,以及噻吩并三唑并噻吩类化合物的制造中间体和制造方法。 由于该化合物对T细胞上的CD28的共刺激信号具有抑制作用,因此可用于预防或抑制移植器官或骨髓等中的排斥反应,以及预防或治疗自身免疫疾病或过敏性疾病。
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公开(公告)号:US20100152261A1
公开(公告)日:2010-06-17
申请号:US11996922
申请日:2006-07-25
申请人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
发明人: Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
IPC分类号: A61K31/4196 , A61K31/4164 , C07D249/08 , C07D233/66 , C07D233/56 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/00 , A61P25/00
CPC分类号: C07D233/56 , C07D233/18 , C07D233/60 , C07D233/61 , C07D249/08 , C07D407/06
摘要: A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
摘要翻译: 由以下通式(I)表示的含氮杂环衍生物或其水合物或溶剂化物,其对毒蕈碱性M3受体具有选择性拮抗作用并引起心脏副作用降低,因此是安全的,并且具有优异的药理功效 以及甚至通过吸入给药延长的作用,以及包含该化合物和药学上可接受的载体的药物组合物。
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公开(公告)号:US20070265257A1
公开(公告)日:2007-11-15
申请号:US11662228
申请日:2005-09-08
申请人: Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人: Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号: A61K31/5375 , A61K31/5377 , A61P37/08 , C07D265/30 , C07D413/02
CPC分类号: C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要: A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译: 由式(1)表示的化合物,其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐,其水合物或溶剂化物对CCR3具有亲和性,可以是用于治疗和/或预防免疫或炎性疾病的药物。
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公开(公告)号:US07935700B2
公开(公告)日:2011-05-03
申请号:US11662228
申请日:2005-09-08
申请人: Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
发明人: Yoshihito Tanaka , Shuzo Takeda , Hidemitsu Higashi , Mamoru Matsuura , Fujio Kobayashi , Maiko Hamada , Minoru Tanaka
IPC分类号: A61K31/535 , C07D417/12
CPC分类号: C07D265/30 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要: A compound represented by the formula (1) wherein ring A is aryl optionally having substituent(s) and the like; ring B is arylene optionally having substituent(s) and the like; m=0-2; n=1-5; X is a bond and the like; Y is a bond and the like; and Z is hydrogen atom and the like or a pharmaceutically acceptable salt thereof, and a hydrate or solvate thereof have affinity for CCR3, and can be pharmaceutical products for the treatment and/or prophylaxis of immune or inflammatory diseases.
摘要翻译: 由式(1)表示的化合物,其中环A为任选具有取代基的芳基等; 环B是任选具有取代基的亚芳基等; m = 0-2; n = 1-5; X是一个键等; Y是一个债券等; Z是氢原子等或其药学上可接受的盐,其水合物或溶剂化物对CCR3具有亲和性,可以是用于治疗和/或预防免疫或炎性疾病的药物。
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公开(公告)号:US08513235B2
公开(公告)日:2013-08-20
申请号:US12937187
申请日:2009-04-10
申请人: Akira Nakao , Hiroko Suzuki , Ryo Tatsumi , Maki Seki , Minoru Tanaka , Tomofumi Setsuta , Hiroshi Iwasaki
发明人: Akira Nakao , Hiroko Suzuki , Ryo Tatsumi , Maki Seki , Minoru Tanaka , Tomofumi Setsuta , Hiroshi Iwasaki
IPC分类号: C07C237/10 , C07C237/12 , C07C255/60 , C07D209/44 , C07D271/06 , C07D295/22 , C07D295/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D487/04 , A61K31/55 , A61K31/4035 , A61K31/165 , A61K31/495 , A61K31/4245 , A61K31/454 , A61K31/4196 , A61K31/422 , A61K31/427 , A61K31/416 , A61K31/501 , A61P9/10
CPC分类号: C07D209/44 , C07C237/10 , C07C255/60 , C07C2602/08 , C07D271/06 , C07D295/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention provides a homocysteine synthase inhibitor useful for the prophylaxis or treatment of diseases involving homocysteine synthase. The homocysteine synthase inhibitor is a compound of the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof.
摘要翻译: 本发明提供了可用于预防或治疗涉及同型半胱氨酸合酶的疾病的同型半胱氨酸合成酶抑制剂。 同型半胱氨酸合成酶抑制剂是式(I)的化合物,其中每个符号如本文所定义,或其药理学上可接受的盐或其溶剂合物。
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公开(公告)号:US08147753B2
公开(公告)日:2012-04-03
申请号:US12593707
申请日:2008-03-28
CPC分类号: A61M1/1698 , A61M1/1625 , B01D53/22 , B01D63/02 , B01D2313/38 , B01D2325/38
摘要: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed. Air can be removed while suppressing a reduction in the heat exchange efficiency.
摘要翻译: 热交换器包括通过其中传热介质液体流动的内腔的多个管2,密封件6,其密封多个管2,同时暴露其两端,通过每个管外的血液通道 2形成在管的轴向的中心部分和容纳用密封构件6密封的管2的壳体5.热交换器还包括中空纤维膜3,该中空纤维膜3由多个疏水性和 透气性中空纤维4,其设置在壳体5中的血液通道的入口侧和出口侧的至少一方,使得流过血液通道的液体通过中空纤维膜3.壳体5包括 用于将形成中空纤维膜3的每个中空纤维4的开口端暴露于外部的开口10,并且开口的内侧和中空纤维4之间的间隙被密封。 可以在抑制热交换效率的降低的同时除去空气。
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公开(公告)号:US08115106B2
公开(公告)日:2012-02-14
申请号:US12323468
申请日:2008-11-25
申请人: Minoru Tanaka , Seishi Watanabe
发明人: Minoru Tanaka , Seishi Watanabe
IPC分类号: H05K1/18
CPC分类号: H01L33/62 , H01L24/32 , H01L24/45 , H01L24/48 , H01L24/49 , H01L24/73 , H01L2224/05599 , H01L2224/32225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48227 , H01L2224/48465 , H01L2224/48997 , H01L2224/49429 , H01L2224/73265 , H01L2224/85399 , H01L2224/85951 , H01L2924/00014 , H01L2924/07802 , H01L2924/12041 , H01L2924/12043 , H01L2924/181 , H01L2924/19107 , H01L2924/351 , H01L2924/00 , H01L2924/00012 , H01L2224/45015 , H01L2924/207 , H01L2224/48455
摘要: The disclosed subject matter includes a surface mount electronic device with high reliability and favorable optical characteristics. The surface mount electronic device can include a circuit board with at least one conductor pattern formed on an insulating board and an electronic component that is mounted on a die bonding pad located on the at least one conductor pattern with an adhesive material. The die bonding pad can include a plurality of cutout sections that expose the insulating board and extend towards a center from a circumference thereof. Therefore, the adhesive material can adhere to both the die bonding pad and the insulating board exposed in the plurality of cutout sections along with the electronic component. In this case, the plurality of cutout sections can be formed so as not to drag the adhesive material upwards on each of the side surfaces of the electronic component. Thus, the surface mount electronic device can improve reliability thereof while maintaining predetermined optical characteristics.
摘要翻译: 所公开的主题包括具有高可靠性和良好光学特性的表面贴装电子器件。 表面贴装电子器件可以包括具有形成在绝缘板上的至少一个导体图案的电路板和安装在位于至少一个导体图案上的芯片接合焊盘上的电子部件,该粘合垫具有粘合材料。 芯片接合焊盘可以包括多个切口部分,其暴露绝缘板并从其圆周向中心延伸。 因此,粘合剂材料可以与电子部件一起粘附到裸露接合焊盘和暴露在多个切除部分中的绝缘板。 在这种情况下,可以形成多个切口部,以便在电子部件的每个侧表面上不向上拖动粘合材料。 因此,表面贴装电子器件可以在保持预定的光学特性的同时提高其可靠性。
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公开(公告)号:US07830107B2
公开(公告)日:2010-11-09
申请号:US11988227
申请日:2006-07-03
申请人: Satoshi Inoue , Masayuki Kato , Kazushi Hirose , Takao Koba , Yoshihiro Fujimura , Minoru Tanaka , Hiroki Nishida , Takashi Inoue
发明人: Satoshi Inoue , Masayuki Kato , Kazushi Hirose , Takao Koba , Yoshihiro Fujimura , Minoru Tanaka , Hiroki Nishida , Takashi Inoue
IPC分类号: G05B5/00
CPC分类号: H02H7/0851 , E05F11/445 , E05F15/41 , E05F15/695 , E05Y2400/554 , E05Y2400/58 , E05Y2900/55 , H02H3/44 , H02H7/093
摘要: A safety device for power window comprises a storage unit for storing the pulse width change rate of continuous pulses detected by a pulse width detector during a window glass raising operation at a reference timing, a calculation unit for calculating the pulse width change rate of continuous pulses detected by the pulse width detector during a window glass raising operation at an operational timing and a control unit for comparing the stored value of a pulse width change rate with the calculated value of a pulse width change rate and driving a motor for raising/lowering window glass in a window opening direction when a total of differences between the both pulse change rates exceeds an allowable value.
摘要翻译: 一种用于电动窗的安全装置,包括存储单元,用于存储在参考定时的窗玻璃提升操作期间由脉冲宽度检测器检测到的连续脉冲的脉宽变化率;计算单元,用于计算连续脉冲的脉宽变化率 在操作定时的窗玻璃提升操作期间由脉冲宽度检测器检测的脉冲宽度变化率的存储值与计算出的脉冲宽度变化率的值进行比较,并且驱动用于升高/降低窗口的电动机 当两个脉冲变化率之间的总差异超过允许值时,窗口打开方向上的玻璃。
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公开(公告)号:US20100114004A1
公开(公告)日:2010-05-06
申请号:US12593707
申请日:2008-03-28
CPC分类号: A61M1/1698 , A61M1/1625 , B01D53/22 , B01D63/02 , B01D2313/38 , B01D2325/38
摘要: A heat exchanger includes a plurality of tubes 2 through an inner cavity of which a heat-transfer medium liquid flows, a sealing member 6 that seals the plurality of tubes 2 while exposing both ends thereof, with a blood channel passing outside each of the tubes 2 being formed in a central portion in the axial direction of the tubes, and a housing 5 that accommodates the tubes 2 sealed with the sealing member 6. The heat exchanger further includes a hollow fiber membrane 3 that is formed of a plurality of hydrophobic and gas permeable hollow fibers 4 and that is disposed on at least one of an entrance side and an exit side of the blood channel in the housing 5 so that a liquid flowing through the blood channel passes through the hollow fiber membrane 3. The housing 5 includes openings 10 for exposing open ends of each of the hollow fibers 4 forming the hollow fiber membrane 3 to the outside, and gaps between an inner side of the openings and the hollow fibers 4 are sealed. Air can be removed while suppressing a reduction in the heat exchange efficiency.
摘要翻译: 热交换器包括通过其中传热介质液体流动的内腔的多个管2,密封件6,其密封多个管2,同时暴露其两端,通过每个管外的血液通道 2形成在管的轴向的中心部分和容纳用密封构件6密封的管2的壳体5.热交换器还包括中空纤维膜3,该中空纤维膜3由多个疏水性和 透气性中空纤维4,其设置在壳体5中的血液通道的入口侧和出口侧的至少一方,使得流过血液通道的液体通过中空纤维膜3.壳体5包括 用于将形成中空纤维膜3的每个中空纤维4的开口端暴露于外部的开口10,并且开口的内侧和中空纤维4之间的间隙被密封。 可以在抑制热交换效率的降低的同时除去空气。
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