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公开(公告)号：US20050187193A1
公开(公告)日：2005-08-25
申请号：US11001378
申请日：2004-12-01
申请人： Hieu Phan , Lan Nguyen , Vinh Van Diep , Raymond Azoulay , Harald Eschenhof , Eric Niesor , Craig Bentzen , Robert Ife
发明人： Hieu Phan , Lan Nguyen , Vinh Van Diep , Raymond Azoulay , Harald Eschenhof , Eric Niesor , Craig Bentzen , Robert Ife
IPC分类号： A61K31/675 , C07F9/58 , C07F9/59 , C07F9/6509 , C07F9/6512 , C07F9/6539 , C07F9/6541 , C07F9/547 , A61K31/66
CPC分类号： A61K31/662 , A61K31/675 , C07F9/58 , C07F9/59 , C07F9/650905 , C07F9/650952 , C07F9/6512 , C07F9/6539 , C07F9/6541
摘要： The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
摘要翻译： 本发明涉及新型α-取代的β-氨基乙基膦酸酯和α-取代的β-氨基乙烯基膦酸衍生物及其用于降低apo（a），Lp（a），载脂蛋白B，载脂蛋白B相关脂蛋白（低密度 脂蛋白和非常低密度脂蛋白）和降低血浆总胆固醇水平。
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公开(公告)号：US20050124586A1
公开(公告)日：2005-06-09
申请号：US10503989
申请日：2003-02-03
申请人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Harald Eschenhof , Eric Niesor , Craig Bentzen , Robert Ife
发明人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Harald Eschenhof , Eric Niesor , Craig Bentzen , Robert Ife
IPC分类号： A61K31/675 , A61P3/06 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P43/00 , C07F9/58 , C07F9/6509 , C07F9/653 , C07F9/6539 , A61K31/401 , A61K31/366
CPC分类号： C07F9/6539 , C07F9/58 , C07F9/650952 , C07F9/653
摘要： The present invention relates to novel α-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
摘要翻译： 本发明涉及新型α-取代芳基烷基膦酸酯衍生物及其用于降低apo（a），Lp（a），载脂蛋白B，载脂蛋白B相关脂蛋白（低密度脂蛋白和极低密度脂蛋白）血浆水平和降低血浆中血浆浓度的用途 总胆固醇水平。
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公开(公告)号：US20050124581A1
公开(公告)日：2005-06-09
申请号：US10504081
申请日：2003-02-03
申请人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Eric Niesor , Craig Bentzen , Robert Ife
发明人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Eric Niesor , Craig Bentzen , Robert Ife
IPC分类号： A61K45/00 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/4418 , A61K31/66 , A61K31/662 , A61P3/06 , A61P7/02 , A61P9/10 , C07F9/40 , C07F9/58 , C07F9/6509 , C07F9/6539 , A61K31/675
CPC分类号： C07F9/6539 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/66 , C07F9/58 , C07F9/650952 , A61K2300/00
摘要： The present invention relates to novel α-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
摘要翻译： 本发明涉及新型α-取代的杂芳基烷基膦酸酯衍生物及其用于降低apo（a），Lp（a），载脂蛋白B，载脂蛋白B相关脂蛋白（低密度脂蛋白和极低密度脂蛋白）的血浆水平和降低血浆中的血浆水平的用途 总胆固醇水平。
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公开(公告)号：US20050075317A1
公开(公告)日：2005-04-07
申请号：US10504744
申请日：2003-02-14
申请人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Eric Niesor , Craig Bentzen , Yves Gellin , Anne Perez , Jean-Luc Thulliard
发明人： Hieu Phan , Lan Nguyen , Raymond Azoulay , Vinh Diep , Eric Niesor , Craig Bentzen , Yves Gellin , Anne Perez , Jean-Luc Thulliard
IPC分类号： A61K31/663 , A61K31/675 , C07F9/58 , C07F9/60 , C07F9/6509 , C07F9/6541 , A61K31/66
CPC分类号： C07F9/60 , A61K31/663 , A61K31/675 , C07F9/58 , C07F9/650952 , C07F9/6541
摘要： The present invention relates to methods of use of aminodiphosphonate to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
摘要翻译： 本发明涉及使用氨基二膦酸盐调节载脂蛋白E水平的方法以及这些化合物在治疗中的应用，包括心血管和神经疾病状态。
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公开(公告)号：US5128331A
公开(公告)日：1992-07-07
申请号：US738430
申请日：1991-07-31
申请人： Lan Nguyen , Eric Niesor , Hieu Phan , Pierre Maechler , Craig Bentzen
发明人： Lan Nguyen , Eric Niesor , Hieu Phan , Pierre Maechler , Craig Bentzen
IPC分类号： A61K31/66 , A61K31/665 , A61P3/06 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/547 , C07F9/655 , C07F9/6571 , C07F9/6574
CPC分类号： C07F9/386 , C07F9/3865 , C07F9/404 , C07F9/4043 , C07F9/4423 , C07F9/65517 , C07F9/657181 , Y10S514/824
摘要： The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及由式（I）的苯酚基取代的新的偕二膦酸衍生物：其制备方法和含有它们的药物组合物。
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6.发明授权Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them 失效苯酚取代的偕二膦酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5043330A
公开(公告)日：1991-08-27
申请号：US323334
申请日：1989-03-14
申请人： Lan Nguyen , Eric Niesor , Hieu Phan , Pierre Maechler , Craig Bentzen
发明人： Lan Nguyen , Eric Niesor , Hieu Phan , Pierre Maechler , Craig Bentzen
IPC分类号： A61K31/66 , A61K31/665 , A61P3/06 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/547 , C07F9/655 , C07F9/6571 , C07F9/6574
CPC分类号： C07F9/386 , C07F9/3865 , C07F9/404 , C07F9/4043 , C07F9/4423 , C07F9/65517 , C07F9/657181 , Y10S514/824
摘要： The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.
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7.发明申请Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators 审中-公开羟磷酸酯和膦酸磷酸酯作为载脂蛋白e调节剂公开(公告)号：US20060128667A1
公开(公告)日：2006-06-15
申请号：US10513553
申请日：2003-05-09
申请人： Imber Montes , Hieu Phan , Lan Nguyen , Emanuele Burattini , Eric Neisor , Anne Perez , Jean Luc Thuillard , Yves Guvon-Gellin , Craig Bentzen
发明人： Imber Montes , Hieu Phan , Lan Nguyen , Emanuele Burattini , Eric Neisor , Anne Perez , Jean Luc Thuillard , Yves Guvon-Gellin , Craig Bentzen
IPC分类号： A61K31/675 , C07F9/547
CPC分类号： C07F9/4056 , C07F9/5537 , C07F9/58
摘要： The present invention relates to the novel hydroxyphosphonates and phosphonophosphates and the methods of their use to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states.
摘要翻译： 本发明涉及新的羟基膦酸酯和膦酸磷酸酯及其用于调节载脂蛋白E水平的方法以及这些化合物在治疗中的应用，包括心血管和神经疾病状态。
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8.发明申请Low molecular weight cellulose mixed esters and their use as low viscosity binders and modifiers in coating compositions 有权低分子量纤维素混合酯及其作为涂料组合物中低粘度粘合剂和改性剂的用途公开(公告)号：US20070088105A1
公开(公告)日：2007-04-19
申请号：US11394008
申请日：2006-03-30
申请人： Michael Shelton , Jessica Posey-Dowty , Luis Perdomo , Daniel Dixon , Paul Lucas , Alan Wilson , Kenneth Walker , Jonathan Lawniczak , Roy Foulk , Hieu Phan , Charlie Freeman , John Booton
发明人： Michael Shelton , Jessica Posey-Dowty , Luis Perdomo , Daniel Dixon , Paul Lucas , Alan Wilson , Kenneth Walker , Jonathan Lawniczak , Roy Foulk , Hieu Phan , Charlie Freeman , John Booton
IPC分类号： C08L1/00
CPC分类号： C08B3/18 , C08B3/16 , C08G18/6484 , C09D101/14 , C09D201/00 , C08L2666/02 , C08L2666/26
摘要： Cellulose mixed esters are disclosed having low molecular weights and low degrees of polymerization. These new cellulose mixed esters include cellulose acetate propionate and cellulose acetate butyrate. The esters exhibit solubility in a wide range of organic solvents with minimal viscosity increase, are compatible with a wide variety of resins, and are useful in coatings and inks compositions as binder resins and rheology modifiers.
摘要翻译： 公开了具有低分子量和低聚合度的纤维素混合酯。 这些新的纤维素混合酯包括乙酸丙酸纤维素和乙酸丁酸纤维素。 该酯在宽范围的有机溶剂中表现出溶解性，粘度增加最小，与多种树脂相容，并且可用作涂料和油墨组合物作为粘合剂树脂和流变改性剂。
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