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    Process for producing chromone compound
    1.
    发明申请
    Process for producing chromone compound 审中-公开

    公开(公告)号：US20060217565A1

    公开(公告)日：2006-09-28

    申请号：US11443300

    申请日：2006-05-31

    申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    IPC分类号： C07D311/02

    CPC分类号： C07C205/37 ,  C07C201/12 ,  C07D311/24

    摘要： A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R1, R2 and the wavy line have the same meanings as the above, and one of X2 and X3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

    Process for producing chromone compound
    2.
    发明申请
    Process for producing chromone compound 失效
    色酮化合物的制备方法

    公开(公告)号：US20050085664A1

    公开(公告)日：2005-04-21

    申请号：US10506119

    申请日：2003-02-27

    申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    IPC分类号： C07C205/37 ,  C07D311/24 ,  C07C25/53

    CPC分类号： C07C205/37 ,  C07C201/12 ,  C07D311/24

    摘要： A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R1, R2 and the wavy line have the same meanings as the above, and one of X2 and X3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

    摘要翻译： 一种由式（4）表示的二羧酸化合物的制备方法：其中R 1和R 2相同或不同，各自代表低级烷基和波浪线 表示该化合物是E-或Z-异构体或它们的混合物，其特征在于使由式（2）表示的化合物：其中R 1，R 2， >和波浪线具有与上述相同的含义，X 2和X 3之一表示氢，而另一个表示卤素，由式（ 3）：在一个基地的存在下; 一种制备由式（5）表示的硝基色酮化合物的方法：其中R 1具有与上述相同的含义，其特征在于使二羧酸化合物或其羧酸与酸反应; 一种制备氨基色酮化合物的方法，其包括还原硝基色酮化合物; 并提供了包括酰化氨基色酮化合物的酰胺色酮化合物的制备方法。

    Method for producing carboxylic acid compound
    3.
    发明授权
    Method for producing carboxylic acid compound 失效
    羧酸化合物的制造方法

    公开(公告)号：US07511171B2

    公开(公告)日：2009-03-31

    申请号：US10594501

    申请日：2005-03-29

    申请人： Hiroaki Hibino ,  Tomoyasu Yoshida

    发明人： Hiroaki Hibino ,  Tomoyasu Yoshida

    IPC分类号： C07C65/01

    CPC分类号： C07C51/09 ,  C07C65/24

    摘要： The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

    摘要翻译： 本发明提供一种制备由式（3）表示的化合物的方法：其中n为1至6的整数，其特征在于水解含有由式（1）表示的酯化合物的溶液的步骤：其中R 为低级烷基，n为1〜6的整数，式（2）表示的化合物：其中R如上定义，将所得溶液的pH调节至pH4〜8，然后使 得到含有式（3）的羧酸的有机层。

    Method For Producing Carboxylic Acid Compound
    4.
    发明申请
    Method For Producing Carboxylic Acid Compound 失效
    生产羧酸化合物的方法

    公开(公告)号：US20070197824A1

    公开(公告)日：2007-08-23

    申请号：US10594501

    申请日：2005-03-29

    申请人： Hiroaki Hibino ,  Tomoyasu Yoshida

    发明人： Hiroaki Hibino ,  Tomoyasu Yoshida

    IPC分类号： C07C51/367

    CPC分类号： C07C51/09 ,  C07C65/24

    摘要： The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

    摘要翻译： 本发明提供一种制备由式（3）表示的化合物的方法：其中n为1至6的整数，其特征在于水解含有由式（1）表示的酯化合物的溶液的步骤：其中R 为低级烷基，n为1〜6的整数，式（2）表示的化合物：其中R如上定义，将所得溶液的pH调节至pH4〜8，然后使 得到含有式（3）的羧酸的有机层。

    Process for producing chromone compound
    5.
    发明授权
    Process for producing chromone compound 失效
    色酮化合物的制备方法

    公开(公告)号：US07094914B2

    公开(公告)日：2006-08-22

    申请号：US10506119

    申请日：2003-02-27

    申请人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    发明人： Hiroaki Hibino ,  Susumu Ohtsuka ,  Yasunobu Miyamoto ,  Tomoyasu Yoshida ,  Itsuo Okumoto

    IPC分类号： C07D311/24 ,  C07C205/37

    CPC分类号： C07C205/37 ,  C07C201/12 ,  C07D311/24

    摘要： A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or a mixture of them, characterized by reacting a compound represented by the formula (2): wherein R1, R2 and the wavy line have the same meanings as the above, and one of X2 and X3 represents hydrogen and the other represents halogen, with nitrophenol represented by the formula (3): in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): wherein R1 has the same meaning as the above, characterized by reacting the dicarboxylic acid compound or carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound are provided.

    摘要翻译： 一种由式（4）表示的二羧酸化合物的制备方法：其中R 1和R 2相同或不同，各自代表低级烷基和波浪线 表示该化合物是E-或Z-异构体或它们的混合物，其特征在于使由式（2）表示的化合物：其中R 1，R 2， >和波浪线具有与上述相同的含义，X 2和X 3之一表示氢，而另一个表示卤素，由式（ 3）：在一个基地的存在下; 一种制备由式（5）表示的硝基色酮化合物的方法：其中R 1具有与上述相同的含义，其特征在于使二羧酸化合物或其羧酸与酸反应; 一种制备氨基色酮化合物的方法，其包括还原硝基色酮化合物; 并提供了包括酰化氨基色酮化合物的酰胺色酮化合物的制备方法。

    Process for producing N-acylnitroaniline derivative
    6.
    发明授权
    Process for producing N-acylnitroaniline derivative 失效
    N-酰基硝基苯胺衍生物的制备方法

    公开(公告)号：US06630598B2

    公开(公告)日：2003-10-07

    申请号：US09903489

    申请日：2001-07-12

    申请人： Tomoyasu Yoshida

    发明人： Tomoyasu Yoshida

    IPC分类号： C07C20500

    CPC分类号： C07C269/04 ,  C07C231/02 ,  C07C233/15 ,  C07C271/28

    摘要： A process of reacting a nitroaniline compound of formula (2): with an acid anhydride or acid halide is carried out in the presence of an alkali metal compound or an alkaline earth metal compound to produce an acylnitroaniline derivative. The process further includes the step of reacting the resulting product with a compound of formula (5); R2—Y to produce an N-acylnitroaniline derivative of formula (1): The N-acylnitroaniline derivative of formula (1) is a useful intermediate for the production of pharmaceuticals.

    摘要翻译： 使式（2）的硝基苯胺化合物与酸酐或酰卤反应的方法在碱金属化合物或碱土金属化合物的存在下进行，生成酰基硝基苯胺衍生物。 该方法还包括使所得产物与式（5）化合物反应的步骤;制备式（1）的N-酰基硝基苯胺衍生物：式（1）的N-酰基硝基苯胺衍生物是生产中的有用中间体 的药物。