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公开(公告)号：US20100256416A1
公开(公告)日：2010-10-07
申请号：US12734661
申请日：2008-11-07
IPC分类号： C07C229/26
CPC分类号： C07C273/1827 , C07C275/16
摘要： The present invention relates to a process for producing an N-carbamoyl-tert-leucine, characterized in mixing tert-leucine with an isocyanic acid compound while a pH of the mixture is kept at not less than 8.0 and not more than 13.5, wherein an amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to an amount of the tert-leucine. According to the present invention, it becomes possible to easily produce an N-carbamoyl-tert-leucine with high efficiency, while the generation of by-products such as a dipeptide-like compound and a urea compound is prevented.
摘要翻译： 本发明涉及一种N-氨基甲酰基 - 叔 - 亮氨酸的制备方法，其特征在于，将所述混合物的pH值保持在8.0以上且13.5以下的条件下，将叔亮氨酸与异氰酸化合物混合， 异氰酸化合物的量相对于叔亮氨酸的量为0.9倍摩尔以上1.1倍以下。 根据本发明，可以高效率地容易地制造N-氨基甲酰基 - 叔 - 亮氨酸，同时防止二肽类化合物和尿素化合物等副产物的产生。
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公开(公告)号：US08183408B2
公开(公告)日：2012-05-22
申请号：US12734661
申请日：2008-11-07
IPC分类号： C07C273/18
CPC分类号： C07C273/1827 , C07C275/16
摘要： The present invention relates to a process for producing an N-carbamoyl-tert-leucine, characterized in mixing tert-leucine with an isocyanic acid compound while a pH of the mixture is kept at not less than 8.0 and not more than 13.5, wherein an amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to an amount of the tert-leucine. According to the present invention, it becomes possible to easily produce an N-carbamoyl-tert-leucine with high efficiency, while the generation of by-products such as a dipeptide-like compound and a urea compound is prevented.
摘要翻译： 本发明涉及一种N-氨基甲酰基 - 叔 - 亮氨酸的制备方法，其特征在于，将所述混合物的pH值保持在8.0以上且13.5以下的条件下，将叔亮氨酸与异氰酸化合物混合， 异氰酸化合物的量相对于叔亮氨酸的量为0.9倍摩尔以上1.1倍以下。 根据本发明，可以高效率地容易地制造N-氨基甲酰基 - 叔 - 亮氨酸，同时防止二肽类化合物和尿素化合物等副产物的产生。
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公开(公告)号：US08883968B2
公开(公告)日：2014-11-11
申请号：US13876734
申请日：2011-09-30
摘要： The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,wherein the surfactin or the salt thereof is represented by the formula (1): wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 alkyl group or a C9-13 branched alkyl group; and M is an alkali metal, an alkaline earth metal, an optionally-substituted amine or the like.
摘要翻译： 本发明的表面活性素或其盐的制造方法包括将含有支链烷基醇的有机溶剂添加到含有所述表面活性素或其盐的培养液中的步骤，或者将除去不溶成分 从所述培养液中提取所述表面活性素或其盐，其中所述表面活性素或其盐由式（1）表示：其中*表示光学活性中心; X是选自亮氨酸，异亮氨酸和缬氨酸的氨基酸; R为C 9-13烷基或C 9-13支链烷基; M是碱金属，碱土金属，任意取代的胺等。
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4.发明申请METHOD FOR STABILIZING CARBODIIMIDE DERIVATIVE AND STABILIZED COMPOSITION THEREOF 审中-公开用于稳定碳二亚胺衍生物和稳定化合物的方法公开(公告)号：US20100016634A1
公开(公告)日：2010-01-21
申请号：US12439005
申请日：2007-08-30
IPC分类号： C07C267/00
CPC分类号： C07C267/00
摘要： Disclosed is a method for stabilizing a carbodiimide derivative (1) which is a condensing agent useful for production of general synthetic chemical products. Also disclosed is a stabilized composition of the carbodiimide derivative. The method is characterized in that the carbodiimide derivative (1) is handled in an atmosphere wherein the concentration of molecular oxygen in the gas phase within a container is set at not more than 3% by volume and/or in the co-presence of at least one compound selected from the group consisting of antioxidants, N-oxyl compounds, sulfur compounds, amines and Lewis acids.
摘要翻译： 公开了一种稳定碳二亚胺衍生物（1）的方法，碳二亚胺衍生物（1）是可用于生产一般合成化学产品的缩合剂。 还公开了碳二亚胺衍生物的稳定化组合物。 该方法的特征在于，将碳二亚胺衍生物（1）在容器内气相中的分子氧浓度设定为3体积％以下和/或共存于 选自抗氧化剂，N-氧基化合物，硫化合物，胺和路易斯酸的至少一种化合物。
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公开(公告)号：US20130197190A1
公开(公告)日：2013-08-01
申请号：US13876734
申请日：2011-09-30
摘要： The method for producing a surfactin or a salt thereof according to the present invention comprises the steps of adding an organic solvent containing a branched alkyl alcohol to a culture fluid containing the surfactin or the salt thereof, or to a solution obtained by removing an insoluble component from the culture fluid, and extracting the surfactin or the salt thereof with the organic solvent,wherein the surfactin or the salt thereof is represented by the formula (1): wherein * indicates an optically active center; X is an amino acid selected from leucine, isoleucine and valine; R is a C9-13 alkyl group or a C9-13 branched alkyl group; and M is an alkali metal, an alkaline earth metal, an optionally-substituted amine or the like.
摘要翻译： 本发明的表面活性素或其盐的制造方法包括将含有支链烷基醇的有机溶剂添加到含有所述表面活性素或其盐的培养液中的步骤，或者将除去不溶成分 从所述培养液中提取所述表面活性素或其盐，其中所述表面活性素或其盐由式（1）表示：其中*表示光学活性中心; X是选自亮氨酸，异亮氨酸和缬氨酸的氨基酸; R为C 9-13烷基或C 9-13支链烷基; M是碱金属，碱土金属，任意取代的胺等。
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6.发明申请Processes for producing optically active 2-thiomethyl-3-phenylpropionic acid derivative and for producing intermediate therefor 审中-公开光学活性2-硫代甲基-3-苯基丙酸衍生物的制备方法及其制备方法公开(公告)号：US20060089503A1
公开(公告)日：2006-04-27
申请号：US10540023
申请日：2003-12-10
申请人： Takahiro Ohishi , Kohei Mori , Koichi Kinoshita , Katsuji Maehara , Hiroaki Kawasaki , Nobuo Nagashima , Yoshihide Fuse
发明人： Takahiro Ohishi , Kohei Mori , Koichi Kinoshita , Katsuji Maehara , Hiroaki Kawasaki , Nobuo Nagashima , Yoshihide Fuse
IPC分类号： C07D305/12 , C07D405/02
CPC分类号： C07D305/12 , C07C319/14 , C07D317/60 , C07D407/06 , C07C323/56
摘要： The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active P-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.
摘要翻译： 本发明提供简单地生产用作廉价原料的药物中间体的光学活性2-硫代甲基-3-苯基丙酸衍生物的方法。 可以通过与酶的不对称还原反应相对容易地获得的光学活性的2-羟甲基-3-苯基丙酸酯衍生物环化成光学活性的P-内酯衍生物，然后与硫化合物反应以产生光学活性2 硫代甲基-3-苯基丙酸衍生物。
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公开(公告)号：US09293954B2
公开(公告)日：2016-03-22
申请号：US13983895
申请日：2011-12-06
申请人： Hiroaki Kawasaki , Yuichi Yoshikawa
发明人： Hiroaki Kawasaki , Yuichi Yoshikawa
CPC分类号： H02K1/2706 , H02K1/276 , H02K21/16
摘要： Provided are a rotor of a motor capable of attaining a high-speed rotation by appropriately dispersing a stress exerted on a flux barrier portion while reducing a leakage of magnetic flux, and a fan driving motor including the rotor. A second inner wall surface is greater than a first inner wall surface in length in a cross-section perpendicular to a rotational axis (C). A side wall surface has a flux barrier wall surface extending from each of both ends of the second inner wall surface in the cross-section perpendicular to the rotational axis (C), the flux barrier wall surface extending outward relative to the second inner wall surface in an extending direction of the second inner wall surface and more distant from an outer edge of a rotor as it goes from the second inner wall surface toward the first inner wall surface in the cross-section perpendicular to the rotational axis (C).
摘要翻译： 提供一种能够通过适当地分散施加在磁通屏障部分上的应力来实现高速旋转的电动机的转子，同时减少磁通量的泄漏，以及包括转子的风扇驱动电动机。 在垂直于旋转轴线（C）的横截面中，第二内壁表面的长度大于第一内壁表面。 侧壁表面具有从垂直于旋转轴线（C）的横截面中从第二内壁表面的两端各自延伸的通量阻挡壁表面，阻挡壁表面相对于第二内壁表面向外延伸 在第二内壁表面的延伸方向上，在与第二内壁表面垂直于旋转轴线（C）的横截面中从第二内壁表面朝向第一内壁表面更远离转子的外边缘。
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8.发明授权Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent 有权含甲酰基的多孔载体，使用其的吸附剂，其制造方法，以及吸附剂的制造方法公开(公告)号：US09149794B2
公开(公告)日：2015-10-06
申请号：US13266773
申请日：2009-12-03
IPC分类号： C07K16/00 , B01J20/32 , B01J20/289
CPC分类号： C08B37/00 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3229 , B01J20/3244 , B01J20/3248
摘要： The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to transform the part of the spacer into a formyl group; wherein the formyl group content in the porous particle after introduction of the spacer is not more than 3 μmol per 1 mL of the porous particle. Also, the present invention relates to a method for producing an adsorbent, comprising the step of immobilizing an amino group-containing ligand on the formyl group-containing porous base matrix. According to the present invention, a formyl-group containing porous base matrix and an adsorbent produced from the porous base matrix of which adsorption amount is high and which is has high strength and of which ligand is difficult to be leaked are provided.
摘要翻译： 本发明涉及一种含有甲酰基的多孔基质基质的制造方法，包括以下步骤：在含甲酰基的多孔质粒子中引入间隔物; 然后用高碘酸和/或高碘酸盐氧化间隔物，以将部分间隔物转化成甲酰基; 其中间隔物引入后的多孔质粒中的甲酰基含量相对于1mL多孔质粒不超过3μmol。 此外，本发明涉及一种吸附剂的制造方法，其特征在于，含有含氨基的配位体固定在含甲酰基的多孔质基体上的工序。 根据本发明，提供了含有甲酰基的多孔基质基质和由吸附量高，强度高，配体难以泄漏的多孔基质基质生成的吸附剂。
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9.发明授权Apparatus, method and program for vehicle mass estimation, and apparatus, method and program for detecting decrease in tire air pressure 有权用于车辆质量估计的装置，方法和程序，以及用于检测轮胎气压降低的装置，方法和程序公开(公告)号：US08958940B2
公开(公告)日：2015-02-17
申请号：US13241347
申请日：2011-09-23
申请人： Hiroaki Kawasaki
发明人： Hiroaki Kawasaki
CPC分类号： G01G19/086 , B60C23/062
摘要： A vehicle mass estimation apparatus includes a wheel rotation speed information detection device configured to detect rotation speed information regarding the respective wheels of the vehicle; a frequency characteristic estimation device configured to calculate wheel acceleration information based on the rotation speed information of the wheels to estimate a frequency characteristic of the wheel acceleration information; and a vehicle mass estimation device configured to estimate a vehicle mass based on the estimated frequency characteristic. The frequency characteristic estimation device calculates an integrated value of frequency gain magnitudes of the respective frequency domains of front wheels and rear wheels of the vehicle, and the vehicle mass estimation device estimates the vehicle mass based on the ratio among the respective integrated values of the front wheels and rear wheels and a relation calculated in advance between the ratio and the vehicle mass.
摘要翻译： 车辆质量估计装置包括车轮转速信息检测装置，其被配置为检测关于车辆的各车轮的转速信息; 频率特性估计装置，被配置为基于所述车轮的转速信息来计算车轮加速度信息，以估计所述车轮加速度信息的频率特性; 以及车辆质量估计装置，其被配置为基于所估计的频率特性来估计车辆质量。 频率特性估计装置计算车辆的前轮和后轮的各个频域的频率增益量的积分值，车辆质量估计装置基于前方的各个积分值之间的比率来估计车辆质量 车轮和后轮以及在比率和车辆质量之间预先计算的关系。
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10.发明授权Apparatus, method and program for detecting decrease in tire air pressure including means to reject data 有权用于检测轮胎气压降低的装置，方法和程序，包括拒绝数据的装置公开(公告)号：US08299909B2
公开(公告)日：2012-10-30
申请号：US12497283
申请日：2009-07-02
申请人： Hajime Fujita , Hiroaki Kawasaki
发明人： Hajime Fujita , Hiroaki Kawasaki
IPC分类号： G08B21/00
CPC分类号： B60C23/061 , B60C23/062
摘要： An apparatus for detecting a decrease in a tire air pressure includes; a rotation velocity information detection means for regularly detecting tire rotation velocity information regarding the respective wheels of a vehicle; a resonance frequency estimation means for estimating a resonance frequency of the rotation velocity information based on the rotation velocity information obtained by the rotation velocity information detection means; and a determination means for determining, based on the estimated resonance frequency, a decrease in the tire air pressure. The apparatus includes a data rejecting means for rejecting data of rotation velocity information hindering the estimation of the resonance frequency.
摘要翻译： 用于检测轮胎气压降低的装置包括： 旋转速度信息检测装置，用于定期检测关于车辆的各个车轮的轮胎转速信息; 谐振频率估计装置，用于基于由所述旋转速度信息检测装置获得的旋转速度信息来估计所述旋转速度信息的共振频率; 以及确定装置，用于基于所估计的共振频率来确定轮胎空气压力的降低。 该装置包括用于拒绝阻碍谐振频率的估计的旋转速度信息的数据的数据拒绝装置。
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