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    4-Oxoimidazolidine-2-spiropiperidine derivatives
    3.
    发明申请
    4-Oxoimidazolidine-2-spiropiperidine derivatives 失效
    4-氧代咪唑烷-2-螺哌啶衍生物

    公开(公告)号：US20070078153A1

    公开(公告)日：2007-04-05

    申请号：US11603147

    申请日：2006-11-22

    申请人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

    发明人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

    IPC分类号： A61K31/4747 ,  C07D471/10

    CPC分类号： C07D471/10

    摘要： The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for optionally halogen-substituted methine, or nitrogen atom; R1 and R2 stand for lower alkyl or the like; R3 stands for hydrogen or lower alkyl; R4 and R5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like]or salts thereof These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

    摘要翻译： 本发明涉及由通式[I]表示的4-氧代咪唑烷-2-螺哌啶衍生物[其中A 1，A 2，A 3， 任选地，卤素取代的次甲基或氮原子的烷基，亚氨基， R 1和R 2代表低级烷基等; R 3代表氢或低级烷基; R 4和R 5代表氢，或任选被羟基取代的低级烷基等）或其盐这些化合物作为伤害感受肽受体激动剂起作用，并且是 可用作止痛剂，缓解药物对麻醉止痛药的缓解，依赖麻醉止痛药缓解，镇痛增强剂，抗胆碱药物，改善脑功能的药物，精神分裂症治疗药物，治疗退行性神经退行性疾病药物，抗焦虑剂或抗抑郁药物及对尿崩症的治疗 多尿 等等。

    4-oxoimidazolidine-2-spiropiperidine derivatives
    4.
    发明授权
    4-oxoimidazolidine-2-spiropiperidine derivatives 失效
    4-氧代咪唑烷-2-螺哌啶衍生物

    公开(公告)号：US07557117B2

    公开(公告)日：2009-07-07

    申请号：US11603147

    申请日：2006-11-22

    申请人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

    发明人： Masaya Hashimoto ,  Osamu Okamoto ,  Satoshi Ozaki ,  Hisashi Ohta

    IPC分类号： A61K31/438 ,  C07D401/04

    CPC分类号： C07D471/10

    摘要： The invention relates to 4-oxoimidazolidine-2-spiropiperidine derivatives represented by a general formula [I] [in which A1, A2, A3, A4 and A5 stand for optionally halogen-substituted methine, or nitrogen atom; R1 and R2 stand for lower alkyl or the like; R3 stands for hydrogen or lower alkyl; R4 and R5 stand for hydrogen, or lower alkyl which is optionally substituted with hydroxy, or the like]or salts thereof. These compounds act as nociceptin receptor agonist, and are useful as analgesic, reliever from tolerance to narcotic analgesic, reliever from dependence on narcotic analgesic, analgesic enhancer, antiobestic, drug for ameliorating brain function, remedy for schizophrenia, drug for treating regressive neurodegenerative diseases, antianxiety agent or antidepressant and remedy for diabetes insipidus and polyuria; and the like.

    摘要翻译： 本发明涉及由通式[I]表示的4-氧代咪唑烷-2-螺哌啶衍生物[其中A1，A2，A3，A4和A5代表任选卤素取代的次甲基或氮原子; R1和R2代表低级烷基等; R3代表氢或低级烷基; R4和R5代表氢，或任选被羟基取代的低级烷基，或其盐。 这些化合物作为伤害感受肽受体激动剂起作用，可用作镇痛药，缓解麻醉止痛药耐受性，缓解依赖麻醉止痛药，镇痛增强剂，抗胆固醇药，改善脑功能药物，精神分裂症药物治疗，治疗退行性神经退行性疾病药物， 抗焦虑药或抗抑郁药及其治疗尿崩症及多尿症; 等等。

    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
    5.
    发明申请
    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives 有权
    N-二羟基烷基取代的2-氧代 - 咪唑衍生物

    公开(公告)号：US20070015792A1

    公开(公告)日：2007-01-18

    申请号：US11484203

    申请日：2006-07-11

    申请人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    发明人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    IPC分类号： A61K31/454 ,  C07D403/04

    CPC分类号： C07D403/04

    摘要： The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphatic carbocyclic group. These compounds act as nociceptin receptor antagonist, and are useful, for example, as relievers against tolerance to narcotic analgesic, dependence on narcotic analgesic or addiction; analgesic enhancers; antiobestic or appetite suppressors; treating or prophylactic agents for cognitive impairment and dementia/amnesia; agents for treating developmental cognitive abnormality; remedy for schizophrenia; agents for treating neurodegenerative diseases; anti-depressant or treating agents for affective disorder; treating or prophylactic agents for diabetes insipidus; treating or prophylactic agents for polyuria; and remedy for hypotension and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物，其中R代表二羟基取代的C 1 -C 6烷基，Cy代表任选地 取代的C 6 -C 10 - 二环或三环脂族碳环基团。 这些化合物作为伤害感受肽受体拮抗剂起作用，例如可用作对麻醉止痛药的耐受性，对麻醉性镇痛药或成瘾的依赖; 镇痛增强剂; 抗生素或食欲抑制剂; 认知障碍和痴呆/遗忘症的治疗或预防剂; 治疗发育性认知异常的药剂; 精神分裂症补救措施 治疗神经变性疾病的药剂; 用于情感障碍的抗抑郁药或治疗剂; 尿崩症的治疗或预防剂; 多尿症的治疗或预防剂; 并补救低血压等。

    Method for Evaluating Compound Using Barlp and Substance for Regulating Eating and Body Weight
    6.
    发明申请
    Method for Evaluating Compound Using Barlp and Substance for Regulating Eating and Body Weight 审中-公开
    使用Barlp和物质评价化合物调节饮食和体重的方法

    公开(公告)号：US20090025095A1

    公开(公告)日：2009-01-22

    申请号：US11918099

    申请日：2006-04-25

    申请人： Hirohide Nambu ,  Satoshi Ozaki ,  Takeshi Tanaka ,  Hisashi Ohta

    发明人： Hirohide Nambu ,  Satoshi Ozaki ,  Takeshi Tanaka ,  Hisashi Ohta

    IPC分类号： G01N33/53 ,  G01N33/00 ,  C07K16/00 ,  C07H21/04 ,  C07H21/02 ,  C07K14/00 ,  C07K2/00

    CPC分类号： G01N33/74 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/72 ,  G01N2500/10 ,  G01N2800/303

    摘要： It is intended to provide a method for evaluating a compound which regulates eating or body weight characterized by comprising the steps of introducing a BARLP gene and preparing a cell expressing BARLP; bringing a test compound into contact with the cell; and detecting a specific binding of the test compound to the BARLP and a method for evaluating a compound further comprising the step of evaluating a test compound using a nonhuman genetically-engineered animal in which the BARLP gene is inactivated. According to this invention, knowledge about a relationship between BARLP and biological functions is obtained and a method for evaluating a compound targeting BARLP and a BARLP ligand obtained by the evaluation can be provided.

    摘要翻译： 旨在提供一种评估调节进食或体重的化合物的方法，其特征在于包括引入BARLP基因并制备表达BARLP的细胞的步骤; 使测试化合物与细胞接触; 以及检测所述测试化合物与所述BARLP的特异性结合，以及评价化合物的方法，其还包括使用其中所述BARLP基因失活的非人基因工程动物评估测试化合物的步骤。 根据本发明，可以获得关于BARLP与生物功能之间的关系的知识，并且可以提供通过评价获得的靶向BARLP和BARLP配体的化合物的评价方法。

    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
    8.
    发明申请
    N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives 审中-公开
    N-二羟基烷基取代的2-氧代 - 咪唑衍生物

    公开(公告)号：US20080103178A1

    公开(公告)日：2008-05-01

    申请号：US11974130

    申请日：2007-10-11

    申请人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    发明人： Masaya Hashimoto ,  Yoshikazu Iwasawa ,  Hiroshi Kawamoto ,  Hisashi Ohta ,  Satoshi Ozaki ,  Takeshi Sagara ,  Hiroki Sakoh ,  Atsushi Satoh

    IPC分类号： A61K31/454 ,  A61P25/00

    CPC分类号： C07D403/04

    摘要： The invention provides the compounds represented by the formula (I) in which, R stands for a dihydroxy-substituted C1-C6 alkyl group, and Cy stands for an optionally substituted C6-C10 bi- or tri-cyclic aliphatic carbocyclic group. These compounds act as nociceptin receptor antagonist, and are useful, for example, as relievers against tolerance to narcotic analgesic, dependence on narcotic analgesic or addiction; analgesic enhancers; antiobestic or appetite suppressors; treating or prophylactic agents for cognitive impairment and dementia/amnesia; agents for treating developmental cognitive abnormality; remedy for schizophrenia; agents for treating neurodegenerative diseases; anti-depressant or treating agents for affective disorder; treating or prophylactic agents for diabetes insipidus; treating or prophylactic agents for polyuria; and remedy for hypotension and the like.

    摘要翻译： 本发明提供由式（I）表示的化合物，其中R代表二羟基取代的C 1 -C 6烷基，Cy代表任选地 取代的C 6 -C 10 - 二环或三环脂族碳环基团。 这些化合物作为伤害感受肽受体拮抗剂起作用，例如可用作对麻醉止痛药的耐受性，对麻醉性镇痛药或成瘾的依赖; 镇痛增强剂; 抗生素或食欲抑制剂; 认知障碍和痴呆/遗忘症的治疗或预防剂; 治疗发育性认知异常的药剂; 精神分裂症补救措施 治疗神经变性疾病的药剂; 用于情感障碍的抗抑郁药或治疗剂; 尿崩症的治疗或预防剂; 多尿症的治疗或预防剂; 并补救低血压等。

    Information presenting apparatus, information presenting method and computer-readable recording medium
    10.
    发明授权
    Information presenting apparatus, information presenting method and computer-readable recording medium 失效
    信息呈现装置，信息呈现方法和计算机可读记录介质

    公开(公告)号：US08635239B2

    公开(公告)日：2014-01-21

    申请号：US13365695

    申请日：2012-02-03

    申请人： Shirou Wakayama ,  Sumihiko Yamamoto ,  Satoshi Ozaki ,  Hirokazu Nagata

    发明人： Shirou Wakayama ,  Sumihiko Yamamoto ,  Satoshi Ozaki ,  Hirokazu Nagata

    IPC分类号： G06F7/00

    CPC分类号： G06F17/30864

    摘要： A keyword acquiring unit transmits a keyword acquisition request to a first server serving as a keyword providing service, and receives a keyword from the first server. An information acquiring unit transmits an acquisition request of information related to the keyword to a second server serving as an information providing service, and receives the information from the second server. A cover unit presents information acquired by the information acquiring unit to a user. An input unit receives selection of at least one of information presented by the cover unit. A service acquiring unit transmits a search request based on the keyword related to information selected at the input unit to a third server serving as a search service, and acquires a search result from the third server. A socket unit presents the search result to the user.

    摘要翻译： 关键字获取单元向作为关键字提供服务的第一服务器发送关键字获取请求，并从第一服务器接收关键字。 信息获取单元将与关键字相关的信息的获取请求发送到用作信息提供服务的第二服务器，并从第二服务器接收信息。 盖单元将由信息获取单元获取的信息呈现给用户。 输入单元接收由盖单元呈现的信息中的至少一个的选择。 服务获取单元基于与在输入单元处选择的信息相关的关键字将搜索请求发送到用作搜索服务的第三服务器，并从第三服务器获取搜索结果。 插座单元向用户显示搜索结果。