公开(公告)号：US4698352A

公开(公告)日：1987-10-06

申请号：US546165

申请日：1983-10-27

申请人： Hirokazu Narita ,  Yoshinori Konishi ,  Jun Nitta ,  Shunjiro Misumi ,  Hideyoshi Nagaki ,  Isao Kitayama ,  Yoriko Nagai ,  Yasuo Watanabe ,  Nobuyuki Matsubara ,  Shinzaburo Minami ,  Isamu Saikawa

发明人： Hirokazu Narita ,  Yoshinori Konishi ,  Jun Nitta ,  Shunjiro Misumi ,  Hideyoshi Nagaki ,  Isao Kitayama ,  Yoriko Nagai ,  Yasuo Watanabe ,  Nobuyuki Matsubara ,  Shinzaburo Minami ,  Isamu Saikawa

IPC分类号： C07D213/63 ,  C07D209/20 ,  C07D211/90 ,  C07D213/55 ,  C07D213/80 ,  C07D215/14 ,  C07D215/38 ,  C07D215/40 ,  C07D249/08 ,  C07D307/81 ,  C07D317/66 ,  C07D333/24 ,  C07D333/28 ,  C07D333/60 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D521/00 ,  A61K31/455 ,  C07D401/02 ,  C07D405/02

CPC分类号： C07D213/80 ,  C07D209/20 ,  C07D211/90 ,  C07D213/55 ,  C07D215/14 ,  C07D215/38 ,  C07D215/40 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D307/81 ,  C07D317/66 ,  C07D333/24 ,  C07D333/28 ,  C07D333/60 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  Y02P20/55

摘要： This invention relates to a novel 4-oxo-1,4-dihydronicotinic acid derivative ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen or carboxyl-protecting group;R.sup.2 is substituted phenyl and naphthyl, or a substituted or unsubstituted heterocyclic group; andR.sup.3 is haloalkyl, aminoalkyl, or substituted or unsubstituted alkenyl, phenylalkenyl, naphthylalkenyl, phenylalkyl, naphthylalkyl, phenylalkynyl, naphthylalkynyl, heterocyclic alkyl, heterocyclic alkenyl, phenyl, naphthyl, cycloalkyl, cycloalkenyl, carboxylic acyl, iminoalkyl, heterocyclic or bridged hydrocarbon, which has a broad antibacterial spectrum and a low toxicity, and are useful for treatment of diseases of human beings and animals, to a process for producing the same and to an antibacterial agent containing the same.

摘要翻译： 本发明涉及一种新的4-氧代-1,4-二氢烟酸衍生物或其盐，其中R 1是氢或羧基保护基; R2是取代的苯基和萘基，或取代或未取代的杂环基团; 苯基，萘基烷基，苯基炔基，萘基炔基，杂环烷基，杂环烯基，苯基，萘基，环烷基，环烯基，羧酰基，亚氨基烷基，杂环或桥连烃，其中R 3为卤代烷基，氨基烷基或取代或未取代的链烯基 具有广泛的抗菌谱和低毒性，并且可用于治疗人和动物的疾病，其制备方法和含有它们的抗菌剂。