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公开(公告)号：US06828028B1
公开(公告)日：2004-12-07
申请号：US10048367
申请日：2002-01-25
申请人： Hiroki Fukui , Ken Suzuki , Kenshiro Shuto , Nobuyuki Yamamoto , Kazuhiko Ishihara , Nobuo Nakabayashi
发明人： Hiroki Fukui , Ken Suzuki , Kenshiro Shuto , Nobuyuki Yamamoto , Kazuhiko Ishihara , Nobuo Nakabayashi
IPC分类号： B32B2738
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61L33/06 , Y10T428/31511 , Y10T428/31515
摘要： A medical material having a surface which is safe and excellent in stability with the lapse of time and has a high durability as needed in establishing a long-lasting surface lubricity in a wet state and an excellent compatibility with blood, and a method for producing the same. These materials are obtained by forming a coating layer with a coating material containing a polymeric substance (A) having a heterocyclic group represented by the formula (1) on at least a part of a surface of a medical material base, and then ring-opening the heterocyclic group remaining in the coating layer by a nucleophilic compound (N): wherein X represents O, NH or S; and R1 represents H or CH3.
摘要翻译： 一种医用材料，其具有安全性和稳定性优异的时间，并且在建立湿状态下的持久的表面润滑性和与血液的优异的相容性方面需要时具有高的耐久性，以及用于制备 相同。 这些材料通过在包含医药材料基材的表面的至少一部分上的含有式（1）表示的具有杂环基的聚合物质（A）的涂布材料形成涂层而得到，然后开环 通过亲核化合物（N）保留在涂层中的杂环基：其中X表示O，NH或S; 且R 1表示H或CH 3。
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2.发明授权公开(公告)号：US06653423B1
公开(公告)日：2003-11-25
申请号：US10031431
申请日：2002-01-14
申请人： Nobuyuki Yamamoto , Hiroki Fukui , Ken Suzuki
发明人： Nobuyuki Yamamoto , Hiroki Fukui , Ken Suzuki
IPC分类号： C08F13002
CPC分类号： C08F230/02 , C08F226/02
摘要： A random copolymer obtained by polymerizing a monomer composition comprising allylamine or a salt thereof and a monomer bearing a phosphorylcholine-like group, comprising 0.01 to 9 mole % of constituent units (A1) derived from allylamine or a salt thereof and 91 to 99.99 mole % of constituent units (A2) derived from a monomer bearing a phosphorylcholine-like group, and having a number-average molecular weight of 50000 to 5000000. This copolymer is excellent in biocompatibility, can be easily fixed on the surfaces of substrates, and exhibit good surface lubricity when formed into films, thus being useful as medical material.
摘要翻译： 通过使包含烯丙胺或其盐的单体组合物和含有磷酰胆碱样基团的单体聚合而获得的无规共聚物，其包含0.01至9摩尔％的来自烯丙胺或其盐的构成单元（A1）和91至99.99摩尔％ 的衍生自具有磷酰胆碱样基团的单体的构成单元（A2），数均分子量为50000〜5000000。该共聚物的生物相容性优异，可以容易地固定在基材的表面，显示良好 当形成膜时表面润滑性，因此可用作医疗材料。
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3.发明申请公开(公告)号：US20120276179A1
公开(公告)日：2012-11-01
申请号：US13537643
申请日：2012-06-29
申请人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
发明人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
CPC分类号： A61K8/8152 , A61K8/0241 , A61K2800/413 , A61K2800/57 , A61K2800/654 , A61Q1/02 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q19/00 , B82Y5/00
摘要： The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol(meth)acrylate monomer represented by the formula (1): (R1: —H, —CH3; R2: —(CH2)n-; n is an integer of 1 to 4).
摘要翻译： 本发明提供了一种具有良好质地的化妆品，并且能够充分表达神经酰胺作为细胞间脂质的固有功能，例如皮肤屏障功能和毛发保护效果，以及可用于化妆品的化妆品和粉末的纳米颗粒 在上述化妆品中，具有良好的皮肤屏障功能和护发效果，并且容易并入上述化妆品中。 根据本发明的化妆品，纳米颗粒和化妆品粉末含有通过聚合由式（1）表示的甘油（甲基）丙烯酸酯单体的单体材料得到的聚合物：（R1：-H， - CH3; R2： - （CH2）n-; n为1〜4的整数）。
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4.发明申请公开(公告)号：US20100040697A1
公开(公告)日：2010-02-18
申请号：US12581474
申请日：2009-10-19
申请人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
发明人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
CPC分类号： A61K8/8152 , A61K8/0241 , A61K2800/413 , A61K2800/57 , A61K2800/654 , A61Q1/02 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q19/00 , B82Y5/00
摘要： The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol (meth)acrylate monomer represented by the formula (1): (R1: —H, —CH3; R2: —(CH2)n-; n is an integer of 1 to 4).
摘要翻译： 本发明提供了一种具有良好质地的化妆品，并且能够充分表达神经酰胺作为细胞间脂质的固有功能，例如皮肤屏障功能和毛发保护效果，以及可用于化妆品的化妆品和粉末的纳米颗粒 在上述化妆品中，具有良好的皮肤屏障功能和护发效果，并且容易并入上述化妆品中。 根据本发明的化妆品，纳米颗粒和化妆品粉末含有通过聚合由式（1）表示的甘油（甲基）丙烯酸酯单体的单体材料得到的聚合物：（R1：-H， - CH3; R2： - （CH2）n-; n为1〜4的整数）。
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公开(公告)号：US07824665B2
公开(公告)日：2010-11-02
申请号：US11533639
申请日：2006-09-20
申请人： Koji Miyamoto , Yoshimi Sekine , Hiroki Fukui , Kenshiro Shuto
发明人： Koji Miyamoto , Yoshimi Sekine , Hiroki Fukui , Kenshiro Shuto
摘要： The invention provides a quick-drying disinfectant gel for hands that spreads well in rubbing into hands, spreads easily over the hands, forms no scum, and is not sticky before and after drying. The disinfectant gel for hands of the invention contains 0.01 to 2.0 wt % of a maleic anhydride polymer, 0.01 to 5.0 wt % of polysaccharides, 40 to 95 wt % of a lower alcohol, and water, with the total being 100 wt %.
摘要翻译： 本发明提供了一种快速消毒的手糊凝胶，可以很好地涂抹在手中，易于手掌涂抹，不会形成浮渣，干燥前后不粘。 本发明的手用消毒剂凝胶含有0.01〜2.0重量％的马来酸酐聚合物，0.01〜5.0重量％的多糖，40〜95重量％的低级醇和水，总计为100重量％。
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6.发明申请公开(公告)号：US20070148121A1
公开(公告)日：2007-06-28
申请号：US11552608
申请日：2006-10-25
申请人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
发明人： Hiroki Fukui , Yoshimi Sekine , Daisuke Kayaba , Eui-chul Kang , Atsuhiko Ogura , Kenshiro Shuto
IPC分类号： A61K8/81
CPC分类号： A61K8/8152 , A61K8/0241 , A61K2800/413 , A61K2800/57 , A61K2800/654 , A61Q1/02 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q19/00 , B82Y5/00
摘要： The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol(meth)acrylate monomer represented by the formula (1): (R1: —H, —CH3; R2: —(CH2)n-; n is an integer of 1 to 4).
摘要翻译： 本发明提供了一种具有良好质地的化妆品，并且能够充分表达神经酰胺作为细胞间脂质的固有功能，例如皮肤屏障功能和毛发保护效果，以及可用于化妆品的化妆品和粉末的纳米颗粒 在上述化妆品中，具有良好的皮肤屏障功能和护发效果，并且容易并入上述化妆品中。 根据本发明的化妆品，纳米颗粒和化妆品粉末含有通过聚合由式（1）表示的甘油（甲基）丙烯酸酯单体的单体材料得到的聚合物：（R 1） H，-CH 3; R 2： - （CH 2）n - ; n是1至 4）。
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公开(公告)号：US20070065388A1
公开(公告)日：2007-03-22
申请号：US11533639
申请日：2006-09-20
申请人： Koji Miyamoto , Yoshimi Sekine , Hiroki Fukui , Kenshiro Shuto
发明人： Koji Miyamoto , Yoshimi Sekine , Hiroki Fukui , Kenshiro Shuto
摘要： The invention provides a quick-drying disinfectant gel for hands that spreads well in rubbing into hands, spreads easily over the hands, forms no scum, and is not sticky before and after drying. The disinfectant gel for hands of the invention contains 0.01 to 2.0 wt % of a maleic anhydride polymer, 0.01 to 5.0 wt % of polysaccharides, 40 to 95 wt % of a lower alcohol, and water, with the total being 100 wt %.
摘要翻译： 本发明提供了一种快速消毒的手糊凝胶，可以很好地涂抹在手中，易于手掌涂抹，不会形成浮渣，干燥前后不粘。 本发明的手用消毒剂凝胶含有0.01〜2.0重量％的马来酸酐聚合物，0.01〜5.0重量％的多糖，40〜95重量％的低级醇和水，总计为100重量％。
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8.发明授权High purity polysaccharide containing a hydrophobic group and process for producing it 有权含有疏水基团的高纯度多糖及其生产方法公开(公告)号：US06566516B1
公开(公告)日：2003-05-20
申请号：US09530347
申请日：2000-04-25
IPC分类号： C07H100
CPC分类号： C08B37/00 , C08B33/00 , C08B37/0021
摘要： A high purity polysaccharide containing hydrophobic group is produced by a process involving a first process step of producing an isocyanate group-containing hydrophobic compound, wherein one mole of a hydroxyl group-containing hydrocarbon having 12-50 carbon atoms or of a sterol is reacted with a diisocyanate represented by OCN—R1—NCO in which R1 is a hydrocarbyl of 1-50 carbon atoms, a second process step of producing the polysaccharide containing hydrophobic group composed of the hydrocarbon group of 12-50 carbon atoms or of the steryl group, wherein the isocyanate group-containing hydrophobic compound obtained in the first process step is reacted with one or more polysaccharides, and a purification step in which the reaction product in the second process step is purified using a solvent based on a ketone.
摘要翻译： 含有疏水性基团的高纯度多糖通过涉及制造含异氰酸酯基的疏水性化合物的第一工序的工序来制造，其中1摩尔含有12-50个碳原子的羟基或固醇的烃与 由OCN-R1-NCO表示的二异氰酸酯，其中R 1是1-50个碳原子的烃基，制备由12-50个碳原子的烃基或固醇基构成的含有疏水基团的多糖的第二工艺步骤，其中 使第一工序中得到的含异氰酸酯基的疏水性化合物与一种或多种多糖反应，其中使用基于酮的溶剂对第二工序中的反应产物进行纯化的纯化工序。
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公开(公告)号：US10228716B2
公开(公告)日：2019-03-12
申请号：US14348938
申请日：2011-11-09
申请人： Hiroki Fukui
发明人： Hiroki Fukui
摘要： A pedal holding device includes: a four-bar linkage including four links and four joints that connect the four links. Two of the four joints serve as two fixed joints that are provided in a main body of the pedal holding device. One of the four links, which is not connected to the two fixed joints, serves as an intermediate link that is provided with a pedal, such that the pedal is not pivotable relative to the intermediate link. One of four internal angles each defined by corresponding adjacent two of the four links becomes not smaller than 180° at at least one moment in a period of movement of the pedal from its rearward end position to its forward end position. Non-adjacent two of the four links intersect with each other apparently when the pedal is positioned in one of the forward end position and the rearward end position.
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公开(公告)号：US5712330A
公开(公告)日：1998-01-27
申请号：US652463
申请日：1996-06-14
申请人： Michio Funayama , Hiroki Fukui
发明人： Michio Funayama , Hiroki Fukui
CPC分类号： B29B9/14 , B29K2025/00 , B29K2105/06
摘要： There is disclosed a styrenic resin pellet having a length in the range of 2 to 100 mm which comprises a (A) styrenic polymer having syndiotactic configuration and containing a polar group and at least 10% by weight of a (B) glass fiber which is surface-treated with a coupling agent, is impregnated with the styrenic polymer, and has a length equal to the length of the pellet. The styrenic resin pellet is imparted with excellent moldability and improved in general physical properties such as impact resistance and heat resistance, thereby making itself well suited to the raw material for producing molded articles excellent in practical characteristics such as tensile creep at elevated temperatures higher than the glass transition temperature and vibrational fatigue characteristics at elevated temperatures.
摘要翻译： PCT No.PCT / JP95 / 02140 Sec。 371日期1996年6月14日第 102（e）日期1996年6月14日PCT 1995年10月19日PCT PCT。 第WO96 / 12597号公报 日期：1996年5月2日公开了长度为2〜100mm的苯乙烯树脂颗粒，其包含具有间同立构构型并含有极性基团的（A）苯乙烯系聚合物和至少10重量％的（B） 用偶联剂表面处理的玻璃纤维用苯乙烯类聚合物浸渍，其长度等于颗粒的长度。 苯乙烯树脂颗粒赋予了优异的成型性，并提高了耐冲击性和耐热性等一般物理性能，因此本发明非常适合用于制造成型品的原料，该原料具有优异的实用特性，例如高于 玻璃化转变温度和振动疲劳特性。
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