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公开(公告)号：US20060172949A1
公开(公告)日：2006-08-03
申请号：US11322254
申请日：2006-01-03
申请人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
发明人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/06 , A61K38/482 , A61K38/4826 , A61K2300/00
摘要： The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
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公开(公告)号：US07550437B2
公开(公告)日：2009-06-23
申请号：US11322254
申请日：2006-01-03
申请人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
发明人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/06 , A61K38/482 , A61K38/4826 , A61K2300/00
摘要： The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
摘要翻译： 本发明提供了用于安全有效地预防和治疗消化器官疾病，特别是胃溃疡，十二指肠溃疡，胃炎，腹泻，肠炎等的组合物。 还提供了具有新的作用机理的组合物，以解决以前已知的作用机理难以解决的问题。 更具体地说，提供了含有活化作为必需成分的PAR-2的成分的药物组合物，其可用于抑制胃酸分泌，促进消化道粘液分泌，保护消化道粘膜，修复消化器官组织和预防 并治疗消化器官疾病。
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公开(公告)号：US07348306B2
公开(公告)日：2008-03-25
申请号：US11211600
申请日：2005-08-26
申请人： Hiromasa Araki , Atsufumi Kawabata , Shuichi Tanaka , Kenzo Kawai , Hiroyuki Nishikawa , Sachiyo Nishimura
发明人： Hiromasa Araki , Atsufumi Kawabata , Shuichi Tanaka , Kenzo Kawai , Hiroyuki Nishikawa , Sachiyo Nishimura
IPC分类号： A61K38/00
CPC分类号： G02B1/043 , A61K38/06 , A61K38/08 , A61K38/177 , A61K38/482 , A61K38/4826 , A61L27/227
摘要： A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition comprises a component which activates PAR-2. Also, a contact lens which retains and/or contains said composition for promoting lacrimal secretion is provided.
摘要翻译： 提供了一种用于促进泪液分泌的组合物，其可以安全有效地用于泪液分泌促进疗法，而不是常规的泪液成分补充治疗。 组合物包含激活PAR-2的组分。 此外，提供保留和/或含有用于促进泪液分泌的组合物的隐形眼镜。
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公开(公告)号：US20060019904A1
公开(公告)日：2006-01-26
申请号：US11211600
申请日：2005-08-26
申请人： Hiromasa Araki , Atsufumi Kawabata , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
发明人： Hiromasa Araki , Atsufumi Kawabata , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
IPC分类号： A61K38/08
CPC分类号： G02B1/043 , A61K38/06 , A61K38/08 , A61K38/177 , A61K38/482 , A61K38/4826 , A61L27/227
摘要： A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition comprises a component which activates PAR-2. Also, a contact lens which retains and/or contains said composition for promoting lacrimal secretion is provided.
摘要翻译： 提供了一种用于促进泪液分泌的组合物，其可以安全有效地用于泪液分泌促进疗法，而不是常规的泪液成分补充治疗。 组合物包含激活PAR-2的组分。 此外，提供保留和/或含有用于促进泪液分泌的组合物的隐形眼镜。
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5.发明申请PEPTIDE DERIVATIVE AND COMPOSITION FOR PROMOTING TEAR SECRETION COMPRISING THE SAME 有权用于促进包含其中的分泌物的肽衍生物和组合物公开(公告)号：US20110224154A1
公开(公告)日：2011-09-15
申请号：US12996728
申请日：2009-06-19
CPC分类号： A61K9/0048 , A61K9/0051 , A61K38/00 , C07K5/06095
摘要： A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition for promoting lacrimal secretion comprising a peptide derivative represented by the formula (I): and a contact lens which retains and/or contains the composition are provided.
摘要翻译： 提供了一种用于促进泪液分泌的组合物，其可以安全有效地用于泪液分泌促进疗法，而不是常规的泪液成分补充治疗。 提供了包含式（I）表示的肽衍生物的促进泪液分泌的组合物和保留和/或含有该组合物的隐形眼镜。
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6.发明授权Peptide derivative and composition for promoting tear secretion comprising the same 有权用于促进包含其的泪液分泌的肽衍生物和组合物公开(公告)号：US08383595B2
公开(公告)日：2013-02-26
申请号：US12996728
申请日：2009-06-15
IPC分类号： A61K38/05
CPC分类号： A61K9/0048 , A61K9/0051 , A61K38/00 , C07K5/06095
摘要： A composition for promoting lacrimal secretion which can be used safely and effectively in the lacrimal secretion promoting therapy, not in the conventional supplemental therapy of lacrimal fluid components is provided. The composition for promoting lacrimal secretion comprising a peptide derivative represented by the formula (I): and a contact lens which retains and/or contains the composition are provided.
摘要翻译： 提供了一种用于促进泪液分泌的组合物，其可以安全有效地用于泪液分泌促进疗法，而不是常规的泪液成分补充治疗。 提供了包含式（I）表示的肽衍生物的促进泪液分泌的组合物和保留和/或含有该组合物的隐形眼镜。
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