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1.发明授权Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative 有权制备糖链衍生物的方法，结构分析方法和糖链衍生物公开(公告)号：US08318694B2
公开(公告)日：2012-11-27
申请号：US11989012
申请日：2006-07-19
CPC分类号： G01N30/72 , C07H3/06 , C08B37/006 , G01N30/84 , G01N2030/8429 , Y10T436/143333
摘要： A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.
摘要翻译： 一种从寡糖混合物制备寡糖衍生物的方法，其特征在于该方法包括以下步骤：（a）将亲脂基团引入该混合物的寡糖中以获得寡糖衍生物的混合物，和（b）将 寡糖衍生物混合物通过5-羟色胺亲和柱色谱法。
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2.发明授权Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these 有权糖链天冬酰胺衍生物，糖链天冬酰胺，糖链及其制备方法公开(公告)号：US08158763B2
公开(公告)日：2012-04-17
申请号：US11976527
申请日：2007-10-25
摘要： An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose in N-acetylglucosamine on the nonreducing terminal side of an asparagine-linked oligosaccharide wherein the asparagine has amino group protected with a lipophilic protective group, and a process for producing these compounds.
摘要翻译： 具有十一碳-7-糖的天冬酰胺连接的α2,3-寡糖，具有十一碳七糖并含有氟的天冬酰胺连接的α2,6-寡糖和在N中含有至少一个岩藻糖的天冬酰胺连接的寡糖衍生物 - 乙酰基葡糖胺，其中天冬酰胺具有被亲油性保护基保护的氨基的天冬酰胺连接的寡糖的非还原性末端侧，以及这些化合物的制造方法。
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3.发明申请Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative 有权制备糖链衍生物的方法，结构分析方法和糖链衍生物公开(公告)号：US20090215100A1
公开(公告)日：2009-08-27
申请号：US11989012
申请日：2006-07-19
CPC分类号： G01N30/72 , C07H3/06 , C08B37/006 , G01N30/84 , G01N2030/8429 , Y10T436/143333
摘要： A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography.
摘要翻译： 一种从寡糖混合物制备寡糖衍生物的方法，其特征在于该方法包括以下步骤：（a）将亲脂基团引入该混合物的寡糖中以获得寡糖衍生物的混合物，和（b）将 寡糖衍生物混合物通过5-羟色胺亲和柱色谱法。
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4.发明申请公开(公告)号：US20060009421A1
公开(公告)日：2006-01-12
申请号：US10540623
申请日：2003-12-26
IPC分类号： A61K31/715
CPC分类号： B01J20/262 , B01J20/26 , B01J20/265 , B01J20/285 , B01J20/286 , C08B37/00
摘要： A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC group; a 3-branched asparagine-linked oligosaccharide derivative which contains at least one fucose in N-acetylglucosamine on the nonreducing terminal side of the asparagine-linked oligosaccharide of the derivative; asparagine-linked oligosaccharides and oligosaccharides thereof wherein Q is a lipophilic protective group, biotin group or FITC group.
摘要翻译： 生物素基团或FITC基团修饰其中天冬酰胺氨基的氮被修饰的式（1）的3-支链的天冬酰胺连接的寡糖衍生物; 在所述衍生物的天冬酰胺连接的寡糖的非还原末端侧的N-乙酰葡糖胺中含有至少一个岩藻糖的3-支链的天冬酰胺连接的寡糖衍生物; 天冬酰胺连接的寡糖及其寡糖，其中Q是亲脂性保护基，生物素基团或FITC基团。
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公开(公告)号：US07550437B2
公开(公告)日：2009-06-23
申请号：US11322254
申请日：2006-01-03
申请人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
发明人： Hiromasa Araki , Atsufumi Kawabata , Ryotaro Kuroda , Kazuaki Kakehi , Shuichi Tanaka , Kenzo Kawai , Sachiyo Nishimura , Hiroyuki Nishikawa
IPC分类号： A61K38/08
CPC分类号： A61K38/08 , A61K38/06 , A61K38/482 , A61K38/4826 , A61K2300/00
摘要： The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel mechanism of action in order to solve the problems which was difficult to be solved by the side effect previously known mechanisms of action. More particularly, there is provided a pharmaceutical composition containing an ingredient which activates PAR-2 as an essential ingredient, which is useful for inhibiting gastric acid secretion, promoting digestive tract mucus secretion, protecting digestive tract mucosa, repairing tissue of digestive organs, and preventing and treating digestive organs diseases.
摘要翻译： 本发明提供了用于安全有效地预防和治疗消化器官疾病，特别是胃溃疡，十二指肠溃疡，胃炎，腹泻，肠炎等的组合物。 还提供了具有新的作用机理的组合物，以解决以前已知的作用机理难以解决的问题。 更具体地说，提供了含有活化作为必需成分的PAR-2的成分的药物组合物，其可用于抑制胃酸分泌，促进消化道粘液分泌，保护消化道粘膜，修复消化器官组织和预防 并治疗消化器官疾病。
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6.发明申请Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain and processes for producing these 有权糖链天冬酰胺衍生物，糖链天冬酰胺，糖链及其制备方法公开(公告)号：US20080214798A1
公开(公告)日：2008-09-04
申请号：US11976527
申请日：2007-10-25
IPC分类号： C07H3/06
摘要： An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose in N-acetylglucosamine on the nonreducing terminal side of an asparagine-linked oligosaccharide wherein the asparagine has amino group protected with a lipophilic protective group, and a process for producing these compounds.
摘要翻译： 具有十一碳七糖的天冬酰胺连接的α2,3-寡糖，具有十一碳七糖并含有氟的天冬酰胺连接的α2,6-寡糖和在N中含有至少一个岩藻糖的天冬酰胺连接的寡糖衍生物 - 乙酰基葡糖胺，其中天冬酰胺具有被亲油性保护基保护的氨基的天冬酰胺连接的寡糖的非还原性末端侧，以及这些化合物的制造方法。
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7.发明申请Method for separating sugar from compound having glycoside bond, sugar separation system, sugar separation agent kit, standardized sample for sugar separation and assessment system 失效从糖苷键合的化合物中分离糖的方法，糖分离系统，糖分离试剂盒，糖分离和评价系统的标准样品公开(公告)号：US20060211849A1
公开(公告)日：2006-09-21
申请号：US10546961
申请日：2004-01-21
申请人： Kazuaki Kakehi
发明人： Kazuaki Kakehi
IPC分类号： C07H1/00
CPC分类号： C07K1/14 , C07H1/00 , C07K1/18 , C08B37/0003 , G01N30/02 , G01N2030/8813 , G01N2030/8836 , B01D15/361
摘要： In an in-flow chemical reaction system (A) of the present invention, a sample solution (1) containing glycoprotein is injected into a reaction tube (7) in which an alkaline solution continuously flows. When a mixed solution of the sample solution and the alkaline solution reach a thermostat bath (6), reaction for cleaving a glycoside linkage takes place, thereby separating a carbohydrate chain from glycoprotein. From the solution containing the carbohydrate chain, alkali is removed by using an ion-exchange column (12), so that a fraction of a carbohydrate chain (14) is collected into a sample tube (13). In the in-flow chemical reaction system (A), reaction takes place in minutes, so that reaction time is significantly reduced compared to a conventional method. Thus, a glycoside linkage is readily cleaved with high precision in a short time, thereby separating carbohydrate from a glycoside-linkage-having compound.
摘要翻译： 在本发明的流动化学反应体系（A）中，将含有糖蛋白的样品溶液（1）注入到连续流过碱性溶液的反应管（7）中。 当样品溶液和碱性溶液的混合溶液达到恒温槽（6）时，发生用于切割糖苷键的反应，从而将糖链与糖蛋白分离。 从含有碳水化合物链的溶液中，通过使用离子交换柱（12）除去碱，使得将一部分碳水化合物链（14）收集到样品管（13）中。 在流动化学反应体系（A）中，反应在几分钟内进行，因此与常规方法相比，反应时间显着降低。 因此，糖苷键在短时间内以高精度容易地切割，从而从含有糖苷键的化合物分离碳水化合物。
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公开(公告)号：US20060048720A1
公开(公告)日：2006-03-09
申请号：US10537632
申请日：2003-12-01
IPC分类号： A01K37/00
CPC分类号： A01K11/006 , A01K29/00
摘要： The invention refers to an apparatus for detecting an animal (1) having a body part (2) and a head part (3). The apparatus includes an animal passage (4) extending in a transport direction (t), and a sensor device (7,8) arranged to sense the animal in the passage. The passage is defined by a first enclosure member (5) and a second enclosure member (6). The enclosure members are arranged on a respective side of the passage and extend substantially in parallel to the transport direction. The sensor device is arranged to sense a parameter related to a cross-section size of the animal at a determined position in the passage, and to produce a signal when the parameter fulfils a certain condition.
摘要翻译： 本发明涉及一种用于检测具有身体部分（2）和头部（3）的动物（1）的装置。 该装置包括沿输送方向（t）延伸的动物通道（4）和布置成感测通道中的动物的传感器装置（7,8）。 通道由第一外壳构件（5）和第二外壳构件（6）限定。 外壳构件布置在通道的相应侧上并且基本上平行于输送方向延伸。 传感器装置被布置成感测在通道中的确定位置处与动物的横截面尺寸相关的参数，并且当参数满足特定条件时产生信号。
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9.发明授权Low-molecular polysulfated hyaluronic acid derivative and medicine containing same 有权低分子多硫酸化透明质酸衍生物及其含有药物公开(公告)号：US08993536B2
公开(公告)日：2015-03-31
申请号：US13143129
申请日：2010-02-01
申请人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
发明人： Kazuaki Kakehi , Hiroaki Asai , Naohiro Hayashi , Satoshi Shimizu , Fumitaka Goto , Yasuo Koga , Takahiro Tomoyasu , Takao Taki , Yusuke Kato , Satoru Nakazato , Junji Takaba , Atsushi Azuma , Wakako Hirano , Kazunari Izumi , Minoru Kashimoto , Yoko Sakamoto , Takashi Hayashi , Masaru Nishida
IPC分类号： A61K31/728 , A61P11/06 , A61P17/00 , A61P37/08 , C08B37/08
CPC分类号： A61K31/728 , C08B37/0072
摘要： A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SO3H group etc.
摘要翻译： 用于治疗过敏性疾病的低分子量多硫酸化透明质酸衍生物。 用于治疗选自以下通式（IA）或（IB）表示的花粉病，过敏性鼻炎，过敏性结膜炎，特应性皮炎和哮喘的过敏性疾病的药剂; 其中n表示0〜15的数; R各自独立地表示氢原子或SO 3 H基等
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10.发明授权Method for separating carbohydrate in glycoside-linkage-having compound, carbohydrate separating system, carbohydrate separating reagent kit, standard sample for carbohydrate separation, and evaluation system 失效糖苷键合化合物中碳水化合物分离方法，碳水化合物分离系统，碳水化合物分离试剂盒，碳水化合物分离标准样品及评估系统公开(公告)号：US07700745B2
公开(公告)日：2010-04-20
申请号：US10546961
申请日：2004-01-21
申请人： Kazuaki Kakehi
发明人： Kazuaki Kakehi
CPC分类号： C07K1/14 , C07H1/00 , C07K1/18 , C08B37/0003 , G01N30/02 , G01N2030/8813 , G01N2030/8836 , B01D15/361
摘要： In an in-flow chemical reaction system (A) of the present invention, a sample solution (1) containing glycoprotein is injected into a reaction tube (7) in which an alkaline solution continuously flows. When a mixed solution of the sample solution and the alkaline solution reach a thermostat bath (6), reaction for cleaving a glycoside linkage takes place, thereby separating a carbohydrate chain from glycoprotein. From the solution containing the carbohydrate chain, alkali is removed by using an ion-exchange column (12), so that a fraction of a carbohydrate chain (14) is collected into a sample tube (13). In the in-flow chemical reaction system (A), reaction takes place in minutes, so that reaction time is significantly reduced compared to a conventional method. Thus, a glycoside linkage is readily cleaved with high precision in a short time, thereby separating carbohydrate from a glycoside-linkage-having compound.
摘要翻译： 在本发明的流动化学反应体系（A）中，将含有糖蛋白的样品溶液（1）注入到连续流过碱性溶液的反应管（7）中。 当样品溶液和碱性溶液的混合溶液达到恒温槽（6）时，发生用于切割糖苷键的反应，从而将糖链与糖蛋白分离。 从含有碳水化合物链的溶液中，通过使用离子交换柱（12）除去碱，使得将一部分碳水化合物链（14）收集到样品管（13）中。 在流动化学反应体系（A）中，反应在几分钟内进行，因此与常规方法相比，反应时间显着降低。 因此，糖苷键在短时间内以高精度容易地切割，从而从含有糖苷键的化合物分离碳水化合物。
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