公开(公告)号：US5071984A

公开(公告)日：1991-12-10

申请号：US612487

申请日：1990-11-14

申请人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

公开(公告)号：US4992551A

公开(公告)日：1991-02-12

申请号：US435246

申请日：1989-11-13

申请人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

公开(公告)号：US4771068A

公开(公告)日：1988-09-13

申请号：US850200

申请日：1986-04-10

申请人： Masaji Kasai ,  Yutaka Saito ,  Motomichi Kono ,  Akira Sato ,  Hiroshi Sano ,  Kunikatsu Shirahata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Masaji Kasai ,  Yutaka Saito ,  Motomichi Kono ,  Akira Sato ,  Hiroshi Sano ,  Kunikatsu Shirahata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/40 ,  A61P35/00 ,  C07D487/14

CPC分类号： C07D487/14

摘要： Mitomycin derivatives of the formula: ##STR1## wherein X is ##STR2## [wherein R.sub.3 is alkyl, cycloalkyl or optionally substituted phenyl; and R.sub.4 is alkyl or cycloalkyl]; n is an integer of 2 to 8; one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a carbamoyloxymethyl group, or alternatively R.sub.1 and R.sub.2 may be combined together to form a methylene group (.dbd.CH.sub.2); and Y and Z independently represent hydrogen or methyl;exhibit anti-bacterial and anti-tumor activities.

摘要翻译： 下式的丝裂霉素衍生物：其中X为<其中R 3为烷基，环烷基或任选取代的苯基; 和R4是烷基或环烷基]; n为2〜8的整数， R1和R2之一是氢原子，另一个是氨基甲酰氧基甲基，或者R1和R2可以组合在一起形成亚甲基（= CH 2）; Y和Z独立地表示氢或甲基; 表现出抗菌和抗肿瘤活性。

公开(公告)号：US4946957A

公开(公告)日：1990-08-07

申请号：US400883

申请日：1989-08-30

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

公开(公告)号：US4822882A

公开(公告)日：1989-04-18

申请号：US102359

申请日：1987-09-29

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： C07D471/18 ,  C07D498/22 ,  A61K31/495 ,  C07D487/18

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.

公开(公告)号：US4879386A

公开(公告)日：1989-11-07

申请号：US207639

申请日：1988-05-25

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

公开(公告)号：US4877776A

公开(公告)日：1989-10-31

申请号：US288787

申请日：1988-12-22

申请人： Chikara Murakata ,  Akira Sato ,  Masaji Kasai ,  Eiji Kobayashi ,  Makoto Morimoto ,  Shiro Akinaga

发明人： Chikara Murakata ,  Akira Sato ,  Masaji Kasai ,  Eiji Kobayashi ,  Makoto Morimoto ,  Shiro Akinaga

IPC分类号： C07D498/22 ,  A61K31/55 ,  A61P35/00 ,  C07H19/23

CPC分类号： C07H19/23

摘要： A K-252 compound represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently H or OH; X represents COOH, COOR or CH.sub.2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.

公开(公告)号：US4923986A

公开(公告)日：1990-05-08

申请号：US273519

申请日：1988-11-08

申请人： Chikara Murakata ,  Akira Sato ,  Mitsuru Takahashi ,  Eiji Kobayashi ,  Makoto Morimoto ,  Shiro Akinaga ,  Tadashi Hirata ,  Kenichi Mochida ,  Hiroshi Kase ,  Koji Yamada ,  Kazuyuki Iwashashi

发明人： Chikara Murakata ,  Akira Sato ,  Mitsuru Takahashi ,  Eiji Kobayashi ,  Makoto Morimoto ,  Shiro Akinaga ,  Tadashi Hirata ,  Kenichi Mochida ,  Hiroshi Kase ,  Koji Yamada ,  Kazuyuki Iwashashi

IPC分类号： A61K31/55 ,  C07D20060101 ,  C07D498/22

CPC分类号： C07D498/22

摘要： The present invention relates to novel derivatives of K-252, (8R*, 9S*, 11S*)-(-)-9-hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H, 11H-2,7b,11a-triazadibenzo[a,g]cycloocta-[c,d,e,]trinden-1-one, and the compounds are represented by formula (I): ##STR1## wherein W.sub.1, W.sub.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y represent various substituents. The compounds are physiologically active substances that inhibit protein kinase C and exhibit an antitumor activity, and are useful as medicines.

公开(公告)号：US09489872B2

公开(公告)日：2016-11-08

申请号：US13997947

申请日：2011-12-27

申请人： Hiromi Yamamuro ,  Yoshihito Fujii ,  Masamitsu Nagahama ,  Shigeru Kido ,  Akira Sato ,  Masahiko Abe

发明人： Hiromi Yamamuro ,  Yoshihito Fujii ,  Masamitsu Nagahama ,  Shigeru Kido ,  Akira Sato ,  Masahiko Abe

IPC分类号： B01D53/04 ,  B01D53/62 ,  B41M5/337 ,  B41M5/42 ,  B41M5/52 ,  G09F3/02 ,  G09F3/10 ,  F16B2/20 ,  D21H27/00 ,  B01D53/02

CPC分类号： G09F3/10 ,  B01D53/02 ,  B01D53/0407 ,  B01D53/62 ,  B01D2253/106 ,  B01D2253/20 ,  B01D2257/504 ,  B01D2259/45 ,  B01D2259/4541 ,  B41M5/287 ,  B41M5/3377 ,  B41M5/38271 ,  B41M5/392 ,  B41M5/426 ,  B41M5/52 ,  B41M2205/02 ,  B41M2205/30 ,  D21H27/001 ,  F16B2/20 ,  G09F3/005 ,  G09F3/02 ,  G09F2003/0282 ,  G09F2003/0283 ,  Y02A50/2342 ,  Y02C10/04 ,  Y02P70/20 ,  Y02P70/24 ,  Y10T24/1394 ,  Y10T428/14 ,  Y10T428/249994 ,  Y10T428/28 ,  Y10T428/2848

摘要： Provided is one of labels 101, 120, 130 and 140, top layer materials formed on a printing medium 201, 246 and 266, information-bearing media 301, 330, 350 and 360, a solid fuel 401, and a wristband clip 510, having the function of absorbing carbon dioxide to which a new carbon dioxide absorbent is added. Provided are also carbon dioxide reduction methods of absorbing carbon dioxide by burning the same.

摘要翻译： 提供了标签101,120,130和140之一，形成在打印介质201,246和266，信息承载介质301,330,350和360，固体燃料401和腕带夹510上的顶层材料， 具有吸收添加了新的二氧化碳吸收剂的二氧化碳的功能。 还提供了通过燃烧二氧化碳来吸收二氧化碳的二氧化碳还原方法。

公开(公告)号：US08974608B2

公开(公告)日：2015-03-10

申请号：US12081490

申请日：2008-04-16

申请人： Takayuki Hirose ,  Masaharu Edo ,  Akira Sato

发明人： Takayuki Hirose ,  Masaharu Edo ,  Akira Sato

IPC分类号： B22F1/00 ,  H01F1/00 ,  H01F1/03 ,  C22C1/00 ,  H01F41/02 ,  B22F1/02 ,  B22F7/02 ,  C22C33/02 ,  H01F1/24

CPC分类号： H01F41/0246 ,  B22F1/02 ,  B22F7/02 ,  B22F2998/10 ,  C22C33/0228 ,  C22C2202/02 ,  H01F1/24 ,  B22F3/02

摘要： A powder magnetic core with improved high frequency magnetic characteristics and reduced eddy current loss is manufactured by a manufacturing method including the steps of (a) providing coated soft magnetic particles which are particles composed of soft magnetic material which each have been coated with an insulating coating, and insulator particles; (b) forming a magnetic layer by press molding the coated soft magnetic particles in a mold assembly; (c) forming an insulator layer on the magnetic layer by press molding the insulator particles in the mold assembly; and (d) repeating the steps (b) and (c) to fabricate a laminate of alternating magnetic layers and insulator layers and provide the powder magnetic core.

摘要翻译： 通过制造方法制造具有改善的高频磁特性和降低的涡流损耗的粉末磁芯，其包括以下步骤：（a）提供涂覆的软磁性颗粒，其是由软磁性材料构成的颗粒，每个软磁性颗粒均涂覆有绝缘涂层 ，和绝缘体颗粒; （b）通过在模具组件中压制成型所涂覆的软磁性颗粒来形成磁性层; （c）通过在所述模具组件中压模所述绝缘体颗粒在所述磁性层上形成绝缘体层; 和（d）重复步骤（b）和（c）以制造交替磁层和绝缘体层的叠层，并提供粉末磁芯。