摘要:
Thiazolidinecarboxylic acid amides having combined antiallergic and antiasthmatic activities with an antagonist activity against platelet Activating Factor and having the following general formula (I) ##STR1##
摘要:
Compounds of formula (I): ##STR1## in which: Q is nitrogen or .dbd.CH--; R.sup.1 and R.sup.2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R.sup.3 is a substituted alkyl groups, or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R.sup.3 is replaced by a hydrogen atom with a compound to introduce the group R.sup.3.
摘要:
Compounds of formula (I): ##STR1## [wherein: A-- B is .dbd.C.dbd.CH--or a nitrogen atom; R.sup.1 is hydrogen, alkyl, aryl or aralkyl; and Z is alkylene] and pharmaceutically acceptable salts thereof are useful in the treatment and prevention of allergies and asthma.
摘要翻译:式(I)化合物:其中:A-B为= C = CH-或氮原子; R1是氢,烷基,芳基或芳烷基; 和Z是亚烷基]及其药学上可接受的盐可用于治疗和预防过敏和哮喘。
摘要:
Compounds of formula (I): ##STR1## in which: R.sup.1 and R.sup.2 are independently alkyl, alkoxy, trifluoromethyl, nitro or halogen; A is an aliphatic hydrocarbon group having from 2 to 8 carbon atoms whose chain contains at least 2 carbon atoms in a linear chain between the piperidine group and --COOH, said group optionally being unsaturated; and m and n are independently 0, 1, 2 or 3; and pharmaceutically acceptable salts and esters thereof have been found to have valuable anti-histamine properties without the usual side effects of anti-histamines. Methods of preparing the compounds are also provided.
摘要:
An optically active compound of formula (I): ##STR1## in which R.sup.3 represents groups of formula --A--COOR.sup.4, whereinA represents alkylene groups having 3 or 5 carbon atoms andR.sup.4 represents hydrogen or an alkyl group having 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof.
摘要:
Compounds of formula (I): ##STR1## in which: Q is nitrogen or .dbd.CH--; R.sup.1 and R.sup.2 are hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl or halogen; and R.sup.3 is a substituted alkyl groups or a pharmaceutically acceptable salt thereof have valuable anti-allergic and anti-asthmatic activities. The compounds are prepared by reacting a corresponding compound where R.sup.3 is replaced by a hydrogen atom with a compound to introduce the group R.sup.3.
摘要:
Compounds of formula (I): ##STR1## [wherein: R.sup.1 is a cyclic amino group, or a dialkylamino group; R.sup.2 a group of formula --NHCHR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are each alkyl aryl or aralkyl, or together form a cycloalkyl group, or R.sup.2 is an aromatic heterocyclic group, or a group of formula --B--S(O).sub.m --R.sup.5 wherein R.sup.5 is a substituted alkyl group, or an aromatic heterocyclic group; B is an alkylene or alkylidene group; m is 0, 1 or 2; A is a group of formula --CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is 1, 2 or 3]; and salts thereof have valuable anti-ulcer activity.
摘要:
Compounds of formula (I): ##STR1## (in which: R.sup.1 is hydrogen or alkl; R.sup.2 is a variety of groups or atoms; R.sup.3 is optionally substituted hydroxy or --(NH).sub.n --NR.sup.5 R.sup.6, wherein R.sup.5 and R.sup.6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C.sub.1 -C.sub.6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR.sup.1 --NH--COOR.sup.7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R.sup.3 in any order.
摘要翻译:式(I)化合物:其中:R 1是氢或烷基; R 2是各种基团或基团; R 3是任选取代的羟基或 - (NH)n -NR 5 R 6,其中R 5和R 6 是各种基团或原子,优选被杂环取代的烷基,n为0或1; Q为氧或硫; A为C1-C6亚烷基)具有有价值的心血管活性,可用于治疗心脏 疾病 它们可以由相应的化合物制备,所述化合物含有1-环基团-QH的苯环和通过闭环在4-位上的-CO-CHR1-NH-COOR7基团,并引入式-A- CO-R3以任何顺序。
摘要:
A fuel vapor discharge limiting device for limiting communication between a fuel tank and a fuel vapor discharge pipe for discharging a fuel vapor in the fuel tank. The fuel vapor discharge limiting device includes a first float valve for cutting off the communication between the fuel tank and the fuel vapor discharge pipe when a liquid level in the fuel tank rises near a predetermined full level; a relief valve for allowing the communication between the fuel tank and the fuel vapor discharge pipe when an internal pressure in the fuel tank becomes not less than a predetermined value; and a second float valve for blocking the communication allowed by the relief valve when the liquid level in the fuel tank abnormally rises over the predetermined full level. Accordingly, oversupply of liquid fuel to the fuel tank can be prevented, and the internal pressure in the fuel tank can be maintained always within a predetermined permissible range. Furthermore, discharge of the liquid fuel to the fuel vapor discharge pipe can be prevented.
摘要:
A fuel tank structure for a vehicle using gaseous fuel, has a plurality of cylindrical tank main bodies communicating from one another. The plurality of cylindrical tank main bodies are disposed at a fuel tank mount portion in a state of being adjoined from one another.