公开(公告)号：US08105630B2

公开(公告)日：2012-01-31

申请号：US10554921

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuchi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuchi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

IPC分类号： A61K31/50 ,  A61K9/00

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2077 ,  Y10S977/906

摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm.The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.

摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在与至少1nm的ad值相对应的衍射角（2θ）处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。

公开(公告)号：US20090137657A1

公开(公告)日：2009-05-28

申请号：US12067722

申请日：2006-10-16

申请人： Hiroshi Miura ,  Makoto Kanebako

发明人： Hiroshi Miura ,  Makoto Kanebako

IPC分类号： A61K31/405

CPC分类号： A61K9/08 ,  A61K31/405 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38

摘要： The present invention provides an indomethacin-containing external liquid preparation which provides good feeling of use, which exhibits high percutaneous absorption of indomethacin, and which, particularly in a low-temperature environment, does not cause precipitation of crystals with time.The present invention is drawn to an external liquid preparation containing indomethacin, a lower alcohol, water, a sulfite, and polyethylene glycol having an average molecular weight of 3,000 to 15,000.

摘要翻译： 本发明提供了含有吲哚美辛的外用液体制剂，其具有良好的使用感，其表现出高消耗吲哚美辛的经皮吸收，特别是在低温环境下，不会随时间引起晶体沉淀。 本发明涉及含有平均分子量为3,000〜15,000的吲哚美辛，低级醇，水，亚硫酸盐和聚乙二醇的外用液体制剂。

公开(公告)号：US08101207B2

公开(公告)日：2012-01-24

申请号：US10551901

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

IPC分类号： A61K9/20 ,  A61K47/02 ,  A61K47/04 ,  A61K31/50

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2095

摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition.The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.

摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，当进行X射线衍射测定时，该材料在对应于d的衍射角（2θ）为1nm以上）表现出一个以上的峰值。 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。

公开(公告)号：US08673960B2

公开(公告)日：2014-03-18

申请号：US12067722

申请日：2006-10-16

申请人： Hiroshi Miura ,  Makoto Kanebako

发明人： Hiroshi Miura ,  Makoto Kanebako

IPC分类号： A61K31/405

CPC分类号： A61K9/08 ,  A61K31/405 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K47/38

摘要： The present invention provides an indomethacin-containing external liquid preparation which provides good feeling of use, which exhibits high percutaneous absorption of indomethacin, and which, particularly in a low-temperature environment, does not cause precipitation of crystals with time.The present invention is drawn to an external liquid preparation containing indomethacin, a lower alcohol, water, a sulfite, and polyethylene glycol having an average molecular weight of 3,000 to 15,000.

摘要翻译： 本发明提供了含有吲哚美辛的外用液体制剂，其具有良好的使用感，其表现出高消耗吲哚美辛的经皮吸收，特别是在低温环境下，不会随时间引起晶体沉淀。 本发明涉及含有平均分子量为3,000〜15,000的吲哚美辛，低级醇，水，亚硫酸盐和聚乙二醇的外用液体制剂。

公开(公告)号：US20070128273A1

公开(公告)日：2007-06-07

申请号：US10551901

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Yasuo Shinoda ,  Toshio Inagi ,  Hirofumi Takeuchi

IPC分类号： A61K9/20

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2095

摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.

摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，并且当进行X射线衍射测定时，该材料在对应于d为1nm以上的衍射角（2θ）处表现出一个或多个峰）; 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。

公开(公告)号：US20060293327A1

公开(公告)日：2006-12-28

申请号：US10554921

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuichi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuichi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

IPC分类号： A61K31/50 ,  A61K9/00

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2077 ,  Y10S977/906

摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.

摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差的水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在衍射角（2θ）的至少1nm的ad值处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。

公开(公告)号：US20110295189A1

公开(公告)日：2011-12-01

申请号：US13204803

申请日：2011-08-08

申请人： Toshio INAGI ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

发明人： Toshio INAGI ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

IPC分类号： A61M37/00 ,  A61K31/664 ,  A61K31/513 ,  A61K31/405

CPC分类号： A61K9/0009 ,  A61K31/405 ,  A61N1/30

摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.

摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。

公开(公告)号：US20090281063A1

公开(公告)日：2009-11-12

申请号：US12089804

申请日：2006-10-11

申请人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

发明人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

IPC分类号： A61K31/675 ,  A61K31/405 ,  A61K31/513 ,  C07D209/26 ,  C07F9/6584 ,  C07D239/553

CPC分类号： A61K9/0009 ,  A61K31/405 ,  A61N1/30

摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.

摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。

公开(公告)号：US08442629B2

公开(公告)日：2013-05-14

申请号：US12988047

申请日：2009-04-17

申请人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

发明人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

IPC分类号： A61N1/30 ,  A61K33/00

CPC分类号： A61K45/06 ,  A61K9/0009 ,  A61K9/0041 ,  A61K31/555 ,  A61K31/675 ,  A61K33/24 ,  A61N1/044 ,  A61N1/0448 ,  A61K2300/00

摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

摘要翻译： 提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。 一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。

公开(公告)号：US08362027B2

公开(公告)日：2013-01-29

申请号：US13204803

申请日：2011-08-08

申请人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

发明人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

IPC分类号： A61K31/675 ,  A61K31/405 ,  A61K31/513 ,  C07D209/26 ,  C07D239/553 ,  C07F9/6584

CPC分类号： A61K9/0009 ,  A61K31/405 ,  A61N1/30

摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.

摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。