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1.发明授权公开(公告)号：US08105630B2
公开(公告)日：2012-01-31
申请号：US10554921
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuchi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Toshio Inagi , Hirofumi Takeuchi , Tsutomu Kajino , Yoshiaki Fukushima , Haruo Takahashi
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2077 , Y10S977/906
摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm.The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.
摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在与至少1nm的ad值相对应的衍射角（2θ）处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。
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2.发明申请公开(公告)号：US20070128273A1
公开(公告)日：2007-06-07
申请号：US10551901
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
IPC分类号： A61K9/20
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2009 , A61K9/2095
摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.
摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，并且当进行X射线衍射测定时，该材料在对应于d为1nm以上的衍射角（2θ）处表现出一个或多个峰）; 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。
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3.发明授权公开(公告)号：US08101207B2
公开(公告)日：2012-01-24
申请号：US10551901
申请日：2004-04-28
申请人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
发明人： Hiroshi Miura , Makoto Kanebako , Masayuki Kanishi , Yasuo Shinoda , Toshio Inagi , Hirofumi Takeuchi
CPC分类号： A61K31/50 , A61K9/1611 , A61K9/1694 , A61K9/2009 , A61K9/2095
摘要： A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of ±40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2θ) corresponding to d of 1 nm or more); and a method for producing the composition.The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.
摘要翻译： 含有非常低水溶性药物的组合物，该组合物通过用超临界或亚临界二氧化碳流体处理含有非常低水溶性药物和多孔材料的混合物（不包括多孔二氧化硅材料 该材料的平均孔径为1〜20nm，直径在平均孔径的±40％范围内的材料的总孔体积占所有孔的体积的60％以上 的材料，当进行X射线衍射测定时，该材料在对应于d的衍射角（2θ）为1nm以上）表现出一个以上的峰值。 以及该组合物的制造方法。 本发明的非常低水溶性药物的组合物确保极低水溶性药物的溶出度得到改善。
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公开(公告)号：US20090005384A1
公开(公告)日：2009-01-01
申请号：US11813968
申请日：2006-01-24
申请人： Hiroshi Miura , Sumie Haruta , Hirofumi Takeuchi
发明人： Hiroshi Miura , Sumie Haruta , Hirofumi Takeuchi
IPC分类号： A61K31/50
CPC分类号： A61K9/143 , A61K9/2009 , A61K31/4965
摘要： The present invention relates to a method for producing a 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one adsorptive porous material characterized by treating a porous material with a halogen-containing organic solvent in which 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one is dissolved. The production method of the present invention is simple and easy, and the obtained adsorptive porous material is excellent in dissolution properties of 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one.
摘要翻译： 本发明涉及2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪-3-酮吸附多孔材料的制备方法，其特征在于用 其中溶解2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪-3-酮的含卤素的有机溶剂。 本发明的制造方法简单易行，所得到的吸附性多孔体的2-苄基-5-（4-氯苯基）-6- [4-（甲硫基）苯基] -2H-哒嗪的溶解性优异 -3-one。
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公开(公告)号：US20100112043A1
公开(公告)日：2010-05-06
申请号：US12593827
申请日：2008-03-28
CPC分类号： A61K9/1277 , A61K9/007 , A61K9/0078 , A61K9/1271 , A61K45/06 , A61K47/32 , A61K47/36 , A61K48/00 , A61K48/0075 , C12N15/88 , C12N2810/10
摘要： An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration.By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.
摘要翻译： 本发明的目的是提供一种在药物或基因的肺内递送可控性优异且适于肺部给药的脂质体。 通过使用末端疏水化聚乙烯醇和/或壳聚糖改性脂质体的表面，可以适当地调节将包封在脂质体中的药物或基因保留在肺组织表面上并将药物或基因转移到肺组织中， 可以控制体内行为。
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公开(公告)号：US5204999A
公开(公告)日：1993-04-27
申请号：US713437
申请日：1991-06-10
CPC分类号： E03D5/10 , E03D5/00 , E03D9/16 , E03D2201/30 , E03D2201/40 , Y10S4/03
摘要： A flush water supply system comprising a passageway valve mounted in a pipeline for supplying flush water to a toilet stool, and a control circuit for controlling the closing and opening of the passageway valve. A constant flow valve is mounted in the pipeline for keeping a predetermined amount of discharge flow, irrespective of water supply pressure.
摘要翻译： 一种冲洗水供应系统，包括安装在用于向马桶便器提供冲洗水的管道中的通道阀，以及用于控制通道阀的关闭和打开的控制电路。 不管供水压力如何，恒流阀安装在管道中以保持预定量的排放流量。
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公开(公告)号：US5133089A
公开(公告)日：1992-07-28
申请号：US385072
申请日：1989-07-24
CPC分类号： E03D5/00 , E03D5/10 , E03D2201/30
摘要： In a water closet flushing apparatus of the type in which the flushing water from a flushing water supply source is fed through different flushing water feed lines to a bowl portion and a trap discharge passage defined adjacent to the bottom portion of the bowl portion, a water jet injector is provided so as to inject the flushing water jet toward the trap discharge passage, an opening-closing valve is disposed in each of different feed lines, and the operation of the opening-closing valve is controlled by a control unit. The flushing water is flushed into the bowl portion so as to clean the same while the jet of flushing water is injected into the trap discharge passage to cause the same to act as a siphon, whereby waste matter is discharged.
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公开(公告)号：US5057323A
公开(公告)日：1991-10-15
申请号：US367948
申请日：1989-06-19
CPC分类号： A61K9/0065 , A61K9/1676
摘要： A granular medicine with slow drug-release characteristics that is sufficiently absorbed in the intestines, in which the granular medicine has a hollow spherical structure, a drug is dispersed in the shell, which mainly consists of an enteron-soluble polymer. The method for preparing the medicine includes the steps of: (a) mixing a hydrophilic or hydrophobic drug with an enteron-soluble polymer in a mixture of an aliphatic alcohol and a chlorohydrocarbon; and (b) pouring this mixture into water or an aqueous medium, and stirring the solution to precipitate the medicine.
摘要翻译： 具有缓慢的药物释放特性的颗粒药物在肠中充分吸收，其中颗粒药物具有中空球形结构，药物分散在壳中，其主要由肠溶性聚合物组成。 制备药物的方法包括以下步骤：（a）将亲水或疏水性药物与肠溶性聚合物混合在脂族醇和氯代烃的混合物中; 和（b）将该混合物倒入水或水性介质中，并搅拌该溶液以沉淀药物。
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9.发明授权
公开(公告)号：US4955535A
公开(公告)日：1990-09-11
申请号：US409918
申请日：1989-09-20
申请人： Osamu Tsutsui , Hisato Haraga , Kinya Arita , Atsuo Makita , Hirofumi Takeuchi , Ryoichi Tsukada
发明人： Osamu Tsutsui , Hisato Haraga , Kinya Arita , Atsuo Makita , Hirofumi Takeuchi , Ryoichi Tsukada
CPC分类号： H02N2/023 , G05D23/1393 , Y10T137/87249 , Y10T137/87684 , Y10T137/87877
摘要： An automatically operating valve for regulating water flow, especially a mixing valve for automatically mixing hot water and cold water to obtain a mixed water of a desired temperature is characterized by employing piezoelectric actuators for operating valve bodies thereof. Due to such a construction, the valve can not only fully close or open but also carries out the fine flow amount control by regulating the opening rate or angle of the valve body. Especially in case the automatically operating valve is a mixing valve, the mixing ratio of hot water and cold water can be accurately regulated so that the mixed water of a desired temperature can be always automatically obtained.
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公开(公告)号：US4768705A
公开(公告)日：1988-09-06
申请号：US136908
申请日：1987-12-22
CPC分类号： G05D23/1393 , A61H33/0095 , Y10T137/86421
摘要： This invention relates to a cold/hot water discharging apparatus which is used for cold/hot water massage shower, and the like. In order to alternately switch and supply hot water of a predetermined temperature supplied from a hot water source to a discharge portion, a valve of a cold/hot water mixing tap is driven by a motor and is reciprocated in a pre-set period between a position where high temperature hot water is discharged and low temperature hot water is discharged. In each of the periods for discharging low/high temperature hot water, an optimum gain of this period is determined from the previous period and previous gain so as to shorten the discharge period of cold/hot water and to obtain a stable curve of the discharge hot water.
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