公开(公告)号：US20110152342A1

公开(公告)日：2011-06-23

申请号：US13058641

申请日：2009-08-14

申请人： Hiroshi Uchida ,  Mamoru Fukuda ,  Seigo Aritomi

发明人： Hiroshi Uchida ,  Mamoru Fukuda ,  Seigo Aritomi

IPC分类号： A61K31/40

CPC分类号： A61K31/40 ,  A61K9/2018 ,  A61K9/2081 ,  A61K9/2866 ,  A61K9/5015

摘要： A pharmaceutical composition is provided which can easily be prepared and which can prevent decomposition of an aminoacetylpyrrolidine carbonitrile derivative, as an effective component, which derivative is in general instable in a pharmaceutical composition.More specifically, the pharmaceutical composition comprises an aminoacetyl pyrrolidine carbonitrile derivative represented by the following general formula (1): (in the formula (1), A represents CH2, CHF or CF2; and R1 represents a secondary amino group which may have a substituent), and the following components blended with the derivative: (1) a sugar alcohol; (2) calcium carbonate, sodium citrate or sodium sulfate; and (3) a neutral low melting point oily and/or fatty substance.

摘要翻译： 提供了一种药物组合物，其可以容易地制备并且可以防止氨基乙酰基吡咯烷腈衍生物作为有效成分的分解，该衍生物通常在药物组合物中不稳定。 更具体地，药物组合物包含由以下通式（1）表示的氨基乙酰基吡咯烷腈衍生物：（在式（1）中，A表示CH 2，CHF或CF 2; R 1表示可具有取代基的仲氨基 ），并且以下组分与衍生物混合：（1）糖醇; （2）碳酸钙，柠檬酸钠或硫酸钠; 和（3）中性低熔点油性和/或脂肪物质。

公开(公告)号：US20140045824A1

公开(公告)日：2014-02-13

申请号：US14113239

申请日：2012-04-20

申请人： Akinori Goto ,  Mamoru Fukuda

发明人： Akinori Goto ,  Mamoru Fukuda

IPC分类号： C07D473/08 ,  C07D223/26

CPC分类号： C07D473/08 ,  C07B63/00 ,  C07D223/26 ,  C07D487/04

摘要： The present invention relates to a method for producing a complex crystal composed of two or more different compounds, comprising crystallizing the two or more different compounds under a condition at which menthol is heat melted, and a method for screening a complex crystal. In accordance with the method for producing a complex crystal of the present invention, a complex crystal capable of being used as a drug material can be produced rapidly, simply and efficiently. In addition, in accordance with the method for screening a complex crystal of the present invention, a stable complex crystal can be searched, which is industrially useful.

摘要翻译： 本发明涉及一种由两种或更多种不同化合物组成的复合晶体的制造方法，包括在薄荷醇被热熔融的条件下使两种或更多种不同的化合物结晶，以及筛选复合结晶的方法。 根据本发明的复合结晶的制造方法，可以快速，简单，有效地制造能够作为药物材料使用的复合结晶。 此外，根据本发明的复合晶体的筛选方法，可以搜索在工业上有用的稳定的复合晶体。

公开(公告)号：USD341879S

公开(公告)日：1993-11-30

申请号：US900701

申请日：1992-06-17

申请人： Masahito Takasuna ,  Mamoru Fukuda

设计人： Masahito Takasuna ,  Mamoru Fukuda

公开(公告)号：US4345601A

公开(公告)日：1982-08-24

申请号：US138232

申请日：1980-04-07

申请人： Mamoru Fukuda

发明人： Mamoru Fukuda

IPC分类号： A61B17/04 ,  A61B17/06

CPC分类号： A61B17/04 ,  A61B17/0482

摘要： An improved suturing apparatus for continuous suturing of incised or ruptured tissues is disclosed, the preferred form including a curved or arcuate suturing needle and an appendage at the nonpointed end protruding from the needle in a direction opposite the needle tip. A slotted, arcuate sleeve with flanged ends partially encases the needle while permitting internal sliding arcuate movement, the extent of which is dictated by the length of the slot through which the needle appendage slides. A pointed needle cap having suturing thread attached thereto is placed on the tip of the suturing needle. During suturing, the needle cap with attached suturing thread is pushed through the tissues moving in an arcuate path. A grasping device in the needle sleeve retains the needle cap after the needle passes through the tissue and as the suturing needle is withdrawn from the tissue. The suturing needle extends beyond the suture into the needle sleeve end holding the needle cap and engages the needle cap, whereupon the grasping device releases the needle cap, and the suturing needle is retracted, preparing the apparatus for the next suture.

摘要翻译： 公开了一种用于连续缝合切开或破裂的组织的改进的缝合装置，优选的形式包括弯曲或弓形缝合针，以及在与针尖相反的方向从针突出的非点端的附属物。 具有法兰端的开槽弓形套筒部分地包住针头，同时允许内部滑动弓形运动，其范围由针附件滑过的狭槽的长度决定。 具有连接到其上的缝合线的尖针针头被放置在缝合针的尖端上。 在缝合过程中，带有连接缝合线的针帽被推动通过在弓形路径中移动的组织。 针套中的把持装置在针穿过组织之后以及当缝合针从组织中取出时，保持针帽。 缝合针延伸超过缝合线进入保持针帽的针套端，并与针帽接合，由此抓握装置释放针帽，缝合针缩回，为下一缝合准备装置。

公开(公告)号：US4224947A

公开(公告)日：1980-09-30

申请号：US9476

申请日：1979-02-05

申请人： Mamoru Fukuda

发明人： Mamoru Fukuda

IPC分类号： A61B17/04 ,  A61B17/06

CPC分类号： A61B17/04 ,  A61B17/06 ,  A61B17/0491 ,  A61B17/06066 ,  A61B17/06166 ,  A61B2017/06052

摘要： An improved suturing apparatus for non-continuous suturing of ruptured or incised skin. Suturing thread is held in an enclosed reel and fed through tubing into a hollow suturing needle. The suturing thread exits the hollow suturing needle through an aperture proximate to the tip of the hollow suturing needle. Needle-holding forceps hold the hollow suturing needle and assist in forcing the needle tip through the tissue to be sewn. Regulable feed means for moving the thread, such as compressed gas, is introduced into the enclosed reel, tubing or hollow suturing needle. The compressed gas moves toward the lower pressure area created by the aperture in the hollow suturing needle, also pushing and carrying the suturing thread out the aperture. The needle tip is pulled back out of the tissue, leaving the extended thread in the tissue. A sharp edge on the needle aperture is used to cut the suturing thread.

摘要翻译： 一种改进的缝合设备，用于不连续缝合破裂或切开的皮肤。 缝合线保持在封闭的卷轴中，并通过管道进入中空缝合针。 缝合线通过靠近中空缝合针的尖端的孔离开中空缝合针。 夹持镊子夹住中空缝合针，并帮助针尖穿过组织进行缝合。 用于将线（例如压缩气体）移动的可调节进给装置被引入封闭的卷轴，管道或中空缝合针中。 压缩气体朝向由中空缝合针中的孔产生的较低压力区域移动，也将缝合线推出孔。 将针尖从组织中拉出，将延长的线留在组织中。 针孔上的尖锐边缘用于切割缝合线。

公开(公告)号：US20100008383A1

公开(公告)日：2010-01-14

申请号：US12559501

申请日：2009-09-15

申请人： Hidetsugu KOGA ,  Mamoru Fukuda ,  Tatsuhiko Satou

发明人： Hidetsugu KOGA ,  Mamoru Fukuda ,  Tatsuhiko Satou

IPC分类号： H04J3/06

CPC分类号： H04J3/0682 ,  H04L45/00 ,  H04L45/121 ,  H04L47/28

摘要： A synchronized communication system is provided in which even when communication devices are connected in series to a transmission path, devices connected to the communication devices are synchronized so that a communication cycle can be reduced. A second communication device includes a relay path and a return path which do not pass through a storage device, and a path selection switch therefor. A first communication device instructs switching of the return path from the transmission path, measures a transmission path delay time, notifies the second communication device of it, and sends a reference time of the first communication device for each communication cycle. The second communication device corrects its reference time using the transmission path delay time and the reference time. When a new second communication device is found during synchronized communication, the first communication device also performs transmission path delay measurement using the remaining time in the communication cycle.

摘要翻译： 提供了一种同步的通信系统，其中即使当通信设备串联连接到传输路径时，连接到通信设备的设备被同步，从而可以减少通信周期。 第二通信设备包括不通过存储设备的中继路径和返回路径，以及路径选择开关。 第一通信设备指示从传输路径返回路径的切换，测量传输路径延迟时间，通知第二通信设备，并且为每个通信周期发送第一通信设备的参考时间。 第二通信设备使用传输路径延迟时间和参考时间校正其参考时间。 当在同步通信期间发现新的第二通信设备时，第一通信设备还使用通信周期中的剩余时间来执行传输路径延迟测量。

公开(公告)号：US06805152B2

公开(公告)日：2004-10-19

申请号：US10657159

申请日：2003-09-09

申请人： Ikuo Kanzaka ,  Mamoru Fukuda

发明人： Ikuo Kanzaka ,  Mamoru Fukuda

IPC分类号： F16K4900

CPC分类号： F16K31/122 ,  F16K49/002 ,  Y10T137/6525 ,  Y10T137/6606

摘要： A cylindrical heat-generating member is disposed in a valve casing including a valve seat in a flow path connecting main ports, a valve member for opening and closing the valve seat, and a rod connecting the valve member and a piston. A first heater is mounted in the heat-generating member. The heat-generating member and a heat receiving member of the valve member are connected to each other by a heat-transfer member for expansion and contraction. As a result, the valve member is constantly heated through the heat-transfer member irrespective of its open/closed position. When the valve member is open, the heat receiving member comes in contact with the heat-generating member and the valve member is directly heated.

公开(公告)号：US06324362B1

公开(公告)日：2001-11-27

申请号：US09665160

申请日：2000-09-19

申请人： Tadakazu Yokoyama ,  Masashi Hara ,  Mamoru Fukuda

发明人： Tadakazu Yokoyama ,  Masashi Hara ,  Mamoru Fukuda

IPC分类号： G03G1500

CPC分类号： H04N1/00204 ,  H04N1/00127 ,  H04N1/00392 ,  H04N1/00795 ,  H04N1/00816 ,  H04N1/10 ,  H04N1/12 ,  H04N2201/0063

摘要： An image forming apparatus includes an original read-out station which is provided on an image forming apparatus body and on which an original is placed and read out in a predetermined read-out position, a digitizer for designating an area of the original, and an automatic document feeder for feeding an original to the read-out position. The automatic document feeder and the digitizer are mounted on the image forming apparatus body for rotation about respective axes between their respective operative positions where they are opposed to the original read-out station and their respective retracted positions where they are away from the original read-out station to open the original read-out station. The automatic document feeder is provided with a digitizer receiving portion on the side which is opposed to the original read-out station when the automatic document feeder is in the operative position so that the digitizer is received in the digitizer receiving portion of the automatic document feeder when the automatic document feeder and the digitizer are both in their operative positions.

摘要翻译： 图像形成装置包括原稿读出站，其设置在图像形成装置主体上，并且在预定的读出位置放置原稿并读出原稿，用于指定原稿的区域的数字化仪，以及 自动进纸器，用于将原稿输送到读出位置。 自动进稿器和数字化仪安装在图像形成装置主体上，用于围绕各自的轴线在它们相对于原始读出站的各自操作位置和它们相对于原始读出位置离开的各自缩回位置之间旋转， 出站打开原来的读出站。 当自动进纸器处于操作位置时，自动进纸器在一侧设置有与原始读出台相对的数字转换器接收部分，使得数字转换器被接收在自动送稿器的数字转换器接收部分中 当自动进纸器和数字化仪都处于其操作位置时。

公开(公告)号：US4242764A

公开(公告)日：1981-01-06

申请号：US944067

申请日：1978-09-20

申请人： Mamoru Fukuda

发明人： Mamoru Fukuda

IPC分类号： E03D9/08 ,  A47K13/24 ,  A61H35/00

CPC分类号： A47K13/302 ,  E03D9/08

摘要： A hygienic cleaning apparatus that provides the washing of the genital area of a person seated on a toilet by upwardly and inwardly directed nozzles, whose water emanations converge at at least one point underneath the area to be cleaned. Temperatures and volume controls and pre-temperature water testing at a test tube outlet are also provided. A warm-air system provides drying air through ducts in the vicinity of the nozzles. The hygienic cleaning apparatus can also be used in conjunction with a modified toilet seat lid, whereby a hole is made at the point where the spray splashes when the lid is in a closed position, the lid containing channels leading away from such opening and terminating in openings over the seat itself, thereby permitting the seat to be washed clean. The warm air system also provides drying air to dry the seat after such washing.

摘要翻译： 一种卫生清洁设备，其通过向上和向内指向的喷嘴提供坐在马桶上的人的生殖器区域的洗涤，其水发散会聚在待清洁区域下方的至少一个点处。 还提供了温度和体积控制以及试管出口处的预温度水测试。 暖风系统通过喷嘴附近的管道提供干燥空气。 卫生清洁装置还可以与改进的马桶座盖一起使用，由此当盖处于关闭位置时喷雾溅出的位置处形成孔，盖子包含从该开口导出的通道，并终止于 在座椅本身上的开口，从而允许座椅被清洁。 这种洗涤后，暖风系统还提供干燥空气来干燥座椅。

公开(公告)号：US20120029032A1

公开(公告)日：2012-02-02

申请号：US13258061

申请日：2010-03-26

申请人： Mamoru Fukuda ,  Mayuko Takahashi ,  Takahiro Goto

发明人： Mamoru Fukuda ,  Mayuko Takahashi ,  Takahiro Goto

IPC分类号： A61K31/44 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/40 ,  A61K31/403

CPC分类号： A61K9/2009 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4196

摘要： Disclosed is a matrix-type sustained release preparation containing a basic drug unstable against an acid as an active pharmaceutical ingredient, wherein the decomposition of the basic drug unstable against the acid can be prevented and therefore the pH-dependent release can be reduced. A hardly water-soluble basic normal salt is added to a matrix-type sustained release preparation containing a basic drug that is unstable against an acid.

摘要翻译： 公开了含有对酸不稳定的碱性药物作为活性药物成分的基质型持续释放制剂，其中可以防止对酸不稳定的碱性药物的分解，因此可以降低pH依赖性释放。 向含有对酸不稳定的碱性药物的基质型缓释制剂中加入难溶于水的碱性正盐。