公开(公告)号：US4156724A

公开(公告)日：1979-05-29

申请号：US611104

申请日：1975-09-08

申请人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： A61K20060101 ,  A61K31/545 ,  C07D20060101 ,  C07D501/04 ,  C07D501/20 ,  C07D501/24 ,  C07D501/26 ,  C07D501/32 ,  C07D501/34 ,  C07D501/36 ,  C07D501/44 ,  C07D501/46 ,  C07D501/54 ,  C07D501/56 ,  C07D501/60 ,  C07D519/00

CPC分类号： C07D501/34 ,  C07D501/24

摘要： A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.3 group or an --S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial and prepared by the reaction of a compound of the formula (II),ho--a--cooh (ii)wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III), ##STR2## wherein R and X are as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素衍生物，其中A是单环或多环杂芳环，其含有至少一个氮原子作为杂原子并且可以被一个或多个取代基取代; R是被至少一个选自氨基，羟基，脲基和羟甲基的取代基取代的苯基; 并且X是-OCOCH 3基团或-S-Het基团，其中Het是含有1至4个选自氮，氧和硫原子的杂原子的5或6元杂环，其可以被 一种或多种取代基及其无毒的药学上可接受的盐，其可用作抗微生物剂并通过式（II）化合物，其中A如上定义的HO-A-COOH（II） 或其活性衍生物与式（III）化合物，其中R和X如上所定义的其中，或其衍生物。

公开(公告)号：US4160087A

公开(公告)日：1979-07-03

申请号：US795596

申请日：1977-05-10

申请人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Kousaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： A61K31/545 ,  C07D501/34

CPC分类号： C07D501/34 ,  C07D501/24

摘要： A cephalosporin derivative of the formula (I), ##STR1## wherein A is a mono- or polycyclic heteroaromatic ring, which contains at least one nitrogen atom as a hetero atom and which may be substituted with one or more substituents; R is a phenyl group substituted with at least one substituent selected from the group consisting of an amino group, a hydroxy group, a ureido group and a hydroxymethyl group; and X is an --OCOCH.sub.3 group or an --S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial and prepared by the reaction of a compound of the formula (II),ho--a--cooh (ii)wherein A is as defined above, or a reactive derivative thereof, with a compound of the formula (III), ##STR2## wherein R and X are as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素衍生物，其中A是单环或多环杂芳环，其含有至少一个氮原子作为杂原子并且可以被一个或多个取代基取代; R是被至少一个选自氨基，羟基，脲基和羟甲基的取代基取代的苯基; 并且X是-OCOCH 3基团或-S-Het基团，其中Het是含有1至4个选自氮，氧和硫原子的杂原子的5或6元杂环，其可以被 一种或多种取代基及其无毒的药学上可接受的盐，其可用作抗微生物剂并通过式（II）化合物，其中A如上定义的HO-A-COOH（II） 或其活性衍生物与式（III）化合物，其中R和X如上所定义的其中，或其衍生物。

公开(公告)号：US4117126A

公开(公告)日：1978-09-26

申请号：US836922

申请日：1977-09-26

申请人： Hirotada Yamada ,  Kosaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Kosaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： C07D501/24 ,  C07D501/36

CPC分类号： C07D501/24

摘要： A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an --S--Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

公开(公告)号：US4061748A

公开(公告)日：1977-12-06

申请号：US674205

申请日：1976-04-05

申请人： Hirotada Yamada ,  Kosaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Kosaku Okamura ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： C07D519/06 ,  A61K31/545 ,  C07D20060101 ,  C07D501/04 ,  C07D501/24 ,  C07D501/32 ,  C07D501/36 ,  C07D501/60 ,  C07D519/00

CPC分类号： C07D501/24

摘要： A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an -S-Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof.

摘要翻译： 式（I）的头孢菌素衍生物：其中X是-OCOCH 3基团或-S-Het基团，其中Het是含有1-4个杂原子的5-或6-元杂环 可以被一个或多个取代基取代的选自氮，氧和硫原子的原子及其无毒的药学上可接受的盐，其可用作抗微生物材料，并且其通过化合物 式（II）化合物或其衍生物与式（III）化合物反应：其中X如上定义，或其衍生物。

公开(公告)号：US4046904A

公开(公告)日：1977-09-06

申请号：US658035

申请日：1976-02-13

申请人： Hirotada Yamada ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Kosaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

发明人： Hirotada Yamada ,  Hisao Tobiki ,  Norihiko Tanno ,  Kozo Shimago ,  Kosaku Okamura ,  Takenari Nakagome ,  Toshiaki Komatsu ,  Akio Izawa ,  Hiroshi Noguchi ,  Kenji Irie ,  Yasuko Eda

IPC分类号： C07D499/04 ,  C07D499/00 ,  C07D499/64 ,  C07D499/68 ,  A61K31/43

CPC分类号： C07D499/00

摘要： A penicillin of the formula: ##STR1## (i.e. 6-[D-2-(3-hydroxypyridazine-4-carbonamido)-2-(p-hydroxyphenyl)acetamido]penicillanic acid), which is valuable as an antibacterial agent, a nutritional supplement in animal feeds and a therapeutic agent in poultry and mammals including man and is especially useful in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.

摘要翻译： 具有下式的青霉素：即作为抗菌剂有价值的6- [D-2-（3-羟基哒嗪-4-碳酰氨基）-2-（对羟基苯基）乙酰胺o]青霉烷酸） 动物饲料中的营养补充剂和包括人在内的家禽和哺乳动物的治疗剂，并且特别可用于治疗由革兰氏阳性和革兰氏阴性菌引起的感染性疾病。

公开(公告)号：US5196337A

公开(公告)日：1993-03-23

申请号：US513933

申请日：1990-04-24

申请人： Hiroshi Ochi ,  Hiroshi Ohtsuka ,  Shinichi Yokota ,  Hiroshi Noguchi ,  Masazumi Terashima ,  Ikuko Uezumi ,  Kenji Irie

发明人： Hiroshi Ochi ,  Hiroshi Ohtsuka ,  Shinichi Yokota ,  Hiroshi Noguchi ,  Masazumi Terashima ,  Ikuko Uezumi ,  Kenji Irie

IPC分类号： G01N33/569 ,  A61K38/00 ,  A61K39/395 ,  A61P31/04 ,  C07K16/12 ,  C12N5/10 ,  C12N15/02 ,  C12P19/44 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC分类号： C07K16/1214 ,  C12P19/44 ,  A61K38/00

摘要： A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Committee's Classification, and the epitope of which is located at the common structure in the O-antigen of Pseudomonas aeruginosa of serotypes A and H. A hybridoma producing said human monoclonal antibody, and processes for preparing said hybridoma and antibody are also provided.

公开(公告)号：US07364876B2

公开(公告)日：2008-04-29

申请号：US10644084

申请日：2003-08-20

申请人： Yoshimi Takai ,  Kenji Irie ,  Masanori Asada

发明人： Yoshimi Takai ,  Kenji Irie ,  Masanori Asada

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12N15/63 ,  C12N15/12 ,  C07K14/00

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/158

摘要： The objective of the present invention is to provide a gene encoding novel afadin DIL domain-binding protein (ADIP) and use of the novel ADIP protein.The present inventors successfully identified a novel afadin-binding protein (ADIP) using yeast two-hybrid screening in order to identify how the nectin and afadin system organize tight junctions and adherens junctions at the cell-cell junctions. The novel protein is useful for evaluating actin cytoskeleton-controlling agents.

摘要翻译： 本发明的目的是提供一种编码新颖的DIL结构域结合蛋白（ADIP）的基因和该新型ADIP蛋白的用途。 本发明人使用酵母双杂交筛选成功地鉴定了一种新颖的afadin结合蛋白（ADIP），以鉴定Nectin和afadin系统如何在细胞 - 细胞连接处组织紧密连接和粘附连接。 该新型蛋白质可用于评估肌动蛋白细胞骨架控制剂。

公开(公告)号：USD290972S

公开(公告)日：1987-07-21

申请号：US629598

申请日：1984-07-11

申请人： Kenji Irie

设计人： Kenji Irie

公开(公告)号：USD290471S

公开(公告)日：1987-06-23

申请号：US629599

申请日：1984-07-11

申请人： Kenji Irie

设计人： Kenji Irie

公开(公告)号：US20070046268A1

公开(公告)日：2007-03-01

申请号：US11508832

申请日：2006-08-24

申请人： Kenji Irie

发明人： Kenji Irie

IPC分类号： H02J1/00

CPC分类号： H02J7/007 ,  H02J7/0073 ,  H02J2007/006

摘要： A dedicated power supply apparatus includes a regulator that receives power from an external power source, two signal lines to which the regulator is connected, and two resistors, each placed between the regulator and an associated one of the two signal lines.

摘要翻译： 专用电源装置包括从外部电源接收功率的调节器，连接有调节器的两条信号线以及两个电阻器，每个电阻器被放置在调节器和两条信号线之间相关的一条信号线之间。