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    Method for Producing Coated Water-Soluble Particles
    1.
    发明申请
    Method for Producing Coated Water-Soluble Particles 有权
    生产涂层水溶性颗粒的方法

    公开(公告)号：US20120198898A1

    公开(公告)日：2012-08-09

    申请号：US13500267

    申请日：2010-10-05

    申请人： Hiroyuki Fujii ,  Nobuhiro Okada ,  Hideaki Sueta ,  Tadashi Tanaka ,  Kazuyoshi Morita

    发明人： Hiroyuki Fujii ,  Nobuhiro Okada ,  Hideaki Sueta ,  Tadashi Tanaka ,  Kazuyoshi Morita

    IPC分类号： B05D7/00 ,  C05D9/00

    CPC分类号： C05G3/0029 ,  A01N25/26

    摘要： A method for producing coated water-soluble particles in a manner to form two or more coating layers on surfaces of the water-soluble particles, characterized by including: a step A wherein after supplying a first coating material that contains a polyol component and an isocyanate component, a second coating material is additionally supplied to surfaces of first coating bodies that have coating layers formed of the first coating material that has not been sufficiently cured, so that second coating bodies that are provided with coating layers of the second coating material are obtained.

    摘要翻译： 一种在水溶性颗粒表面形成两层或多层涂层的方法，其特征在于包括：步骤A，其中在提供含有多元醇组分和异氰酸酯的第一涂料之后， 另外将第二涂层材料提供给具有由第一涂层材料形成的涂层未被充分固化的第一涂层体的表面，从而获得设置有第二涂层材料涂层的第二涂覆体 。

    Coated Granular Material and Method for Producing Coated Granular Material
    3.
    发明申请
    Coated Granular Material and Method for Producing Coated Granular Material 审中-公开
    涂层颗粒材料和生产涂层颗粒材料的方法

    公开(公告)号：US20130039965A1

    公开(公告)日：2013-02-14

    申请号：US13576316

    申请日：2011-03-04

    申请人： Hiroyuki Fujii ,  Nobuhiro Okada ,  Hideaki Sueta ,  Tadashi Tanaka ,  Kazuyoshi Morita

    发明人： Hiroyuki Fujii ,  Nobuhiro Okada ,  Hideaki Sueta ,  Tadashi Tanaka ,  Kazuyoshi Morita

    IPC分类号： A01N25/28 ,  C05F11/00 ,  B05D7/00 ,  A01P13/00 ,  A01P11/00 ,  A01P17/00 ,  C05G5/00 ,  A01P7/04

    CPC分类号： C05G3/0029 ,  A01N25/26

    摘要： A coated granular material of the present invention includes: a water-soluble granular substance; a coating layer applied to at least a surface of the water-soluble granular substance and containing a thermosetting resin A formed from a resin liquid having a molar ratio A of isocyanate groups to hydroxyl groups of 0.5 to 0.99; and a protection layer applied to the coating layer and containing a thermosetting resin B formed from a resin liquid having a molar ratio B of isocyanate groups to hydroxyl groups of 0.75 to 2.0, wherein the molar ratio B of the protection layer is greater than the molar ratio A of the coating layer. The present coated granular material is capable of achieving both of a short-term release pattern and an initial release limiting function and maintaining good quality.

    摘要翻译： 本发明的涂覆颗粒材料包括：水溶性颗粒状物质; 涂覆层至少涂覆在水溶性颗粒状物质的表面上并含有由异氰酸酯基的摩尔比A与羟基的树脂液体形成的热固性树脂A为0.5〜0.99; 以及保护层，其涂布在涂层上并含有由异氰酸酯基的摩尔比B与羟基的摩尔比为0.75〜2.0构成的热固性树脂B，其中保护层的摩尔比B大于摩尔比 涂层的比A。 本发明的涂覆颗粒材料能够实现短期释放模式和初始释放限制功能，并且保持良好的质量。

    Isolation of anti-mutagenic factor from cabbage juice
    4.
    发明授权
    Isolation of anti-mutagenic factor from cabbage juice 失效
    从白菜汁中分离抗诱变因子

    公开(公告)号：US4191752A

    公开(公告)日：1980-03-04

    申请号：US940089

    申请日：1978-09-06

    申请人： Tsuneo Kada ,  Tadashi Inoue ,  Kazuyoshi Morita

    发明人： Tsuneo Kada ,  Tadashi Inoue ,  Kazuyoshi Morita

    IPC分类号： C07K14/415 ,  C07G7/04

    CPC分类号： C07K14/415

    摘要： Anti-mutagenic factor is fractionated from cabbage juice. The factor is a protein having an M. W. of about 48,000 when determined by the SDS-gel electrophoresis and shows characteristic adsorptions at 280 nm and 404 nm. The factor substantially inhibits the mutagenic activity of various mutagens such as pyrolysates of amino acids.

    摘要翻译： 从白菜汁中分解抗诱变因子。 该因子是当通过SDS-凝胶电泳测定时具有约48,000的M.W的蛋白质，并且在280nm和404nm处显示特征吸附。 该因子基本上抑制各种诱变剂的诱变活性，例如氨基酸的热解产物。

    Preparation of sodium carbonate anhydride
    5.
    发明授权
    Preparation of sodium carbonate anhydride 失效
    碳酸酐酐的制备

    公开(公告)号：US4252781A

    公开(公告)日：1981-02-24

    申请号：US26449

    申请日：1979-04-02

    申请人： Yosisige Fujita ,  Shigeki Ishine ,  Kazuyoshi Morita

    发明人： Yosisige Fujita ,  Shigeki Ishine ,  Kazuyoshi Morita

    IPC分类号： C01D7/12 ,  C01D7/37

    CPC分类号： C01D7/37 ,  C01D7/12

    摘要： A thick suspension of sodium carbonate anhydride is obtained by countercurrent contacting of a high pressure steam and a suspension of sodium bicarbonate or sodium sesquicarbonate in a concentrated solution of sodium carbonate. The decomposition reaction is promoted to near completion by maintaining the reaction temperature above 150.degree. C. to realize a high HCO.sub.3.sup.- ion concentration in the solution. The sodium carbonate anhydride suspension is cooled to cause transition of the anhydride to the monohydrate, followed by the separation of the crystalline monohydrate from the mother liquor. Calcination of this monohydrate gives a dense soda ash featuring a high purity and a uniform particle size, while the mother liquor is recycled for the preparation of the sodium bicarbonate suspension.

    摘要翻译： 通过高压蒸汽和碳酸氢钠或倍半碳酸钠的混悬液在碳酸钠浓缩液中的逆流接触获得浓碳酸酐酐的浓悬浮液。 通过保持反应温度高于150℃，使分解反应促进到接近完成，以在溶液中实现高HCO3-离子浓度。 将碳酸钠酸酐悬浮液冷却以使酸酐转化为一水合物，然后从母液中分离结晶一水合物。 该一水合物的煅烧产生具有高纯度和均匀粒度的致密苏打灰，同时将母液循环用于制备碳酸氢钠悬浮液。

    High-molecular-weight substance having desmutagenic activity extracted from the root of burdock, and process for separating and purifying said substance
    7.
    发明授权
    High-molecular-weight substance having desmutagenic activity extracted from the root of burdock, and process for separating and purifying said substance 失效
    从牛蒡根中提取脱发活性的高分子量物质以及分离和纯化所述物质的方法

    公开(公告)号：US4474771A

    公开(公告)日：1984-10-02

    申请号：US371489

    申请日：1982-04-23

    申请人： Kazuyoshi Morita

    发明人： Kazuyoshi Morita

    IPC分类号： C12N1/00 ,  A61K36/00 ,  A61K36/28 ,  A61K38/00 ,  A61P3/00 ,  A61P43/00 ,  C07G99/00 ,  C07K14/415 ,  A61K35/78

    CPC分类号： A61K36/28

    摘要： A high-molecular-weight substance extracted from the root of edible burdock, characterized in that(1) said substance is soluble in water and alkaline aqueous solutions,(2) said substance is adsorbable to an anion exchange cellulose but not adsorbable to a cation exchange cellulose,(3) said substance has an absorption wavelength peak within a range of 280 nm to 300 nm, and(4) said substance has a desmutagenicity such that when the number of revertant colonies from Salmonella TA98 is determined by using 2-nitro-p-phenylenediamine as a mutagen in accordance with the inhibitory effect test described in the specification, the concentration of the high-molecular-weight substance at which the desmutagenic rate (%) becomes 50% is 4 to 6 parts by weight per part by weight of the 2-nitro-p-phenylenediamine.The high-molecular-weight substance may be prepared by a process which comprises the steps of:(a) centrifuging the juice of burdock to remove foreign materials therefrom,(b) mixing the resulting supernatant with a phosphate buffer having a concentration of 1 to 2 moles and a pH of about 6.5 to about 7.5, salting out the mixture with a water-soluble alkali metal or ammonium salt of an inorganic acid, and thereafter collecting the precipitate,(c) dissolving the precipitate in a phosphate buffer having a concentration of about 10 to about 400 mM and a pH of about 6.5 to about 7.5, and dialyzing the resulting solution, and(d) ultrafiltering the dialyzate and withdrawing the concentrate and as required, lyophilizing the concentrate to yield a powder.The high-molecular-weight substance is useful for preventing the induction of mutation in an animal by a mutagen.

    摘要翻译： 从食用牛蒡根提取的高分子量物质，其特征在于：（1）所述物质可溶于水和碱性水溶液，（2）所述物质可吸附于阴离子交换纤维素，但不能吸附于阳离子 交换纤维素，（3）所述物质的吸收波长峰值在280nm〜300nm的范围内，（4）所述物质具有致死性，使得当来自沙门氏杆菌TA98的回廊菌落数通过2-硝基 对苯二胺作为诱变剂，根据说明书中所述的抑制效果试验，脱水率（％）变为50％的高分子量物质的浓度为4〜6重量份/份 重量的2-硝基对苯二胺。 高分子量物质可以通过以下步骤制备：（a）离心牛蒡汁从其中除去异物，（b）将所得上清液与浓度为1的磷酸盐缓冲液 2摩尔，pH为约6.5至约7.5，用无机酸的水溶性碱金属或铵盐盐析混合物，然后收集沉淀物，（c）将沉淀物溶解在具有浓度的磷酸盐缓冲液中 约10至约400mM，pH约6.5至约7.5，并透析所得溶液，（d）超滤透析液并取出浓缩物，并根据需要将浓缩物冷冻干燥以产生粉末。 高分子量物质可用于通过诱变剂预防动物诱导突变。