公开(公告)号：US06432963B1

公开(公告)日：2002-08-13

申请号：US09581595

申请日：2000-06-15

申请人： Hiroyuki Hisamichi ,  Ryo Naito ,  Souichirou Kawazoe ,  Akira Toyoshima ,  Kazuhito Tanabe ,  Eiichi Nakai ,  Atsushi Ichikawa ,  Akiko Orita ,  Makoto Takeuchi

发明人： Hiroyuki Hisamichi ,  Ryo Naito ,  Souichirou Kawazoe ,  Akira Toyoshima ,  Kazuhito Tanabe ,  Eiichi Nakai ,  Atsushi Ichikawa ,  Akiko Orita ,  Makoto Takeuchi

IPC分类号： C07D23948

CPC分类号： C07D239/42 ,  C07D231/12 ,  C07D233/56 ,  C07D239/38 ,  C07D239/47 ,  C07D239/48 ,  C07D239/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： Pyrimidine-5-carboxamide derivatives represented by a general formula (I) or salts thereof [wherein each symbol has the following meaning; X: O, S, NR1, CO, NR1CO, CONR1, C═N—OR1 or a bond, Y: a lower alkylene group which may be substituted by OR1 or —NHR1, or a bond, Z: O, NR2 or a bond, A: H, or a lower alkyl which may have a substituent, a —CO-lower alkyl which may have a substituent, an aryl which may have a substituent, a heteroaryl which may have a substituent, a cycloalkyl which may have a substituent or a nitrogen-containing saturated heterocyclic group which may have a substituent, B: an aryl which may have a substituent or a heteroaryl group which may have a substituent, R1, R2: H, a lower alkyl or a —CO-lower alkyl group].

摘要翻译： 由通式（I）表示的嘧啶-5-甲酰胺衍生物或其盐[其中每个符号具有以下含义; X：O，S，NR1，CO，NR1CO，CONR1，C = N-OR1或键，Y 可以被OR 1或-NHR 1取代的低级亚烷基或键，Z：O，NR 2或键，A：H或可以具有取代基的低级烷基，可以是-CO-低级烷基 具有取代基，可以具有取代基的芳基，可以具有取代基的杂芳基，可以具有取代基的环烷基或可以具有取代基的含氮饱和杂环基，B：可以具有取代基的芳基， 或可以具有取代基的杂芳基，R 1，R 2：H，低级烷基或-CO-低级烷基]。

公开(公告)号：US06797706B1

公开(公告)日：2004-09-28

申请号：US10009276

申请日：2001-12-10

申请人： Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

发明人： Hiroyuki Hisamichi ,  Souichirou Kawazoe ,  Kazuhito Tanabe ,  Atsushi Ichikawa ,  Akiko Orita ,  Takayuki Suzuki ,  Kenichi Onda ,  Makoto Takeuchi

IPC分类号： A61K3133

CPC分类号： C07D213/82 ,  C07D239/48 ,  C07D241/26 ,  C07D253/07

摘要： A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, —CO-lower alkyl, or —SO2-lower alkyl; R2: H, a (substituted) lower alkyl, —O-lower alkyl, —S-lower alkyl, —O-aryl, nitro, cyano, or the like; R3: —CO2H, —CO2-lower alkyl, -lower alkylene-CO2H, —NH2, -alkylene-NH2 or the like.

摘要翻译： 具有取代基-XAR 3，-N（R 1） - （Ph被R 2取代的）的含氮六元杂环化合物和-CONH 2，其盐，其前药和 含有与活性成分相同的Syk抑制剂。 （式中，A：（取代的）低级亚烷基，（取代的）亚芳基等; X：NR 4，CONR 4，NR 4 CO，O或S; R 1 R 4：H，低级烷基，-CO-低级烷基或-SO 2 - 低级烷基; R 2：H，（取代的）低级烷基，-O-低级烷基，-S-低级 烷基，-O-芳基，硝基，氰基等; R 3：-CO 2 H，-CO 2 - 低级烷基， - 低级亚烷基-CO 2 H，-NH 2， - 亚烷基-NH 2等。

公开(公告)号：US06642264B1

公开(公告)日：2003-11-04

申请号：US09958174

申请日：2001-10-05

申请人： Satoshi Hayashibe ,  Hirotsune Itahana ,  Masamichi Okada ,  Atsuyuki Kohara ,  Kyoichi Maeno ,  Kiyoshi Yahiro ,  Itsuro Shimada ,  Kazuhito Tanabe ,  Kenji Negoro ,  Takashi Kamikubo ,  Shuichi Sakamoto

发明人： Satoshi Hayashibe ,  Hirotsune Itahana ,  Masamichi Okada ,  Atsuyuki Kohara ,  Kyoichi Maeno ,  Kiyoshi Yahiro ,  Itsuro Shimada ,  Kazuhito Tanabe ,  Kenji Negoro ,  Takashi Kamikubo ,  Shuichi Sakamoto

IPC分类号： A61K31425

CPC分类号： C07D513/04 ,  A61K31/429

摘要： This invention relates to novel thiazolo[3,2-a]benzoimidazole derivatives represented by the following general formula (I). The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments. The invention also provides novel compounds useful as intermediates for the synthesis of the compounds of the invention. (Symbols in the formula represent the following meanings. R1: carbamoyl, carbonyl, oxy, amino, carbonylamino or the like which may be substituted; R2: hydrogen, lower alkyl or the like; and R3, R4 and R5: hydrogen, lower alkyl and the like which may be the same or different from one another.)

摘要翻译： 本发明涉及由以下通式（I）表示的新型噻唑并[3,2-a]苯并咪唑衍生物。 本发明提供的化合物特异性地代表代谢型谷氨酸受体并用作药物。 本发明还提供了可用作合成本发明化合物的中间体的新化合物（式中的符号表示以下含义：R 1：可以被取代的氨基甲酰基，羰基，氧基，氨基，羰基氨基等 R 2：氢，低级烷基等; R 3，R 4和R 5：氢，低级烷基等可以彼此相同或不同。）

公开(公告)号：US06880663B2

公开(公告)日：2005-04-19

申请号：US10295904

申请日：2002-11-18

申请人： Hiroyuki Fujiki ,  Koichi Sagawa ,  Kazuhito Tanabe

发明人： Hiroyuki Fujiki ,  Koichi Sagawa ,  Kazuhito Tanabe

IPC分类号： B62D25/08 ,  B62D21/15 ,  B60K5/12

CPC分类号： B62D21/155

摘要： A vehicle front structure includes a side member to be placed to extend in the longitudinal direction of a vehicle. The side member includes a support portion to support a power unit at a support point, and a weak section which is formed on the front side of the support point toward the front of the vehicle, and which is weakened in an upper side and lateral sides of the side member with respect to a lower side of the side member.

摘要翻译： 一种车辆前部结构，其包括沿车辆的纵向方向延伸的侧部件。 侧部件包括支撑部分，用于在支撑点处支撑动力单元;以及弱部，其形成在支撑点的前侧上朝向车辆前部，并且在上侧和外侧被削弱 侧构件相对于侧构件的下侧。