公开(公告)号：US5420252A

公开(公告)日：1995-05-30

申请号：US46431

申请日：1993-04-09

申请人： Hiroyuki Kato ,  Shinji Yoshitake ,  Suguru Suzuki ,  Noboru Suzuki ,  Toshio Seto ,  Naoko Nagaoka ,  Yoshiharu Mizui

发明人： Hiroyuki Kato ,  Shinji Yoshitake ,  Suguru Suzuki ,  Noboru Suzuki ,  Toshio Seto ,  Naoko Nagaoka ,  Yoshiharu Mizui

IPC分类号： C07K1/22 ,  A61K38/00 ,  A61P7/02 ,  C07K14/00 ,  C07K14/81 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/15 ,  C12P21/02 ,  C12R1/91 ,  A61K38/17 ,  C07K14/435

CPC分类号： C07K14/8128 ,  A61K38/00

摘要： A novel human antithrombin III (AT III) mutant having a high antithrombin activity in the absence of heparin and effective in the treatment of thrombotic disorders as an anticoagulant, which is obtained by mutating amino acids at the reactive site and the heparin binding site of human AT III into another amino acids with the use of the recombinant DNA technology with the use of a DNA coding for AT III as a template. The invention also relates to a method for mass producing the above-described mutant by incubating a host transformed by an expression vector having the cDNA of the mutant inserted therein.

摘要翻译： 一种新型人类抗凝血酶III（AT III）突变体，其在不存在肝素的情况下具有高抗凝血酶活性，并且有效地治疗作为抗凝血剂的血栓形成障碍，其通过在人的反应部位和肝素结合位点突变氨基酸而获得 AT III使用重组DNA技术，使用编码AT III的DNA作为模板，将其转化为另一种氨基酸。 本发明还涉及通过温育由其中插入有突变体的cDNA的表达载体转化的宿主来批量生产上述突变体的方法。

公开(公告)号：US4663671A

公开(公告)日：1987-05-05

申请号：US691890

申请日：1985-01-16

申请人： Toshio Seto

发明人： Toshio Seto

IPC分类号： H04N1/411 ,  H04N1/413 ,  H04M1/40

CPC分类号： H04N1/413

摘要： A facsimile apparatus capable of saving time necessary for the transmission of video data. Pixel signals provided by scanning a document in both the lengthwise and widthwise directions are digitized, then encoded, and then stored in independent buffer memories. One of the buffer memories storing a smaller amount of video data than the other is chosen to transmit its video data to a remote station over a line.

摘要翻译： 一种能够节省传输视频数据所需的时间的传真装置。 通过沿长度方向和宽度方向扫描文档提供的像素信号被数字化，然后被编码，然后存储在独立的缓冲存储器中。 选择存储比另一个更少量的视频数据的缓冲存储器之一，以通过一行将其视频数据发送到远程站。

公开(公告)号：US5124810A

公开(公告)日：1992-06-23

申请号：US523346

申请日：1990-05-14

申请人： Toshio Seto

发明人： Toshio Seto

IPC分类号： H04N1/04 ,  G06T1/00 ,  H04N1/12 ,  H04N1/193 ,  H04N1/401 ,  H04N1/407

CPC分类号： H04N1/401 ,  H04N1/121 ,  H04N1/193

摘要： An image reading apparatus for reading an image on a sheet. The apparatus comprises an image reading part for scanning a predetermined area, including the sheet, one scanning line by one scanning line for producing an output image signal. A white reference image part is provided within the predetermined area so as to be scanned by the image reading part. A black reference image part is provided within the predetermined area so as to be scanned by the image reading part. A white reference memory is supplied with the output image signal from the image reading part for storing the output image signal supplied thereto, and a black reference memory is supplied with the output image signal from the image reading part for storing the output image signal supplied thereto. An image correction part is supplied with the output image signal from the image reading part and further with a first reference signal and a second reference signal from the white and black reference memories for producing a corrected image signal. A controller controls the reading operation of the white reference memory and the black reference memory. In the image forming apparatus, the effect of shading is eliminated, the quality of image recording is improved, and the size of the sheet on which the image to be read can be detected.

摘要翻译： 一种用于读取片材上的图像的图像读取装置。 该装置包括用于扫描包括纸张的预定区域的图像读取部分，一条扫描线由一条扫描线产生输出图像信号。 在预定区域内设置白色参考图像部分，以便被图像读取部分扫描。 在预定区域内设置黑色参考图像部分，以便被图像读取部分扫描。 白图参考存储器被提供有来自图像读取部分的输出图像信号，用于存储提供给其的输出图像信号，黑色参考存储器被提供有来自图像读取部分的输出图像信号，用于存储提供给它的输出图像信号 。 图像校正部分被提供有来自图像读取部分的输出图像信号，并且还提供来自白色和黑色参考存储器的第一参考信号和第二参考信号，以产生校正的图像信号。 控制器控制白色参考存储器和黑色参考存储器的读取操作。 在图像形成装置中，消除了阴影的效果，提高了图像记录的质量，并且可以检测到要读取的图像的片材的尺寸。

公开(公告)号：US4601058A

公开(公告)日：1986-07-15

申请号：US742094

申请日：1985-06-06

申请人： Toshio Seto

发明人： Toshio Seto

IPC分类号： H04N1/401 ,  G06K9/38

CPC分类号： H04N1/401

摘要： An image reading device for a facsimile apparatus or the like compensates outputs of a line image sensor by shading while reading out a document. When a reference signal representative of a particular pixel is derived from a contaminated portion of a reference or white image, a reference signal representative of a pixel which immediately precedes that particular pixel is substituted for the latter. This promotes accurate shading which is free from the influence of contamination.

摘要翻译： 用于传真装置等的图像读取装置在读取文档时通过阴影补偿线形图像传感器的输出。 当代表特定像素的参考信号从参考或白色图像的污染部分导出时，表示紧接在该特定像素之前的像素的参考信号被替换为后者。 这促进了不受污染影响的精确阴影。

公开(公告)号：US5316933A

公开(公告)日：1994-05-31

申请号：US961521

申请日：1992-10-15

申请人： Kentaro Yoshimatsu ,  Yukio Ohya ,  Yasushi Shikata ,  Isao Tanaka ,  Yoshikazu Hasegawa ,  Toshio Seto ,  Toshio Osawa

发明人： Kentaro Yoshimatsu ,  Yukio Ohya ,  Yasushi Shikata ,  Isao Tanaka ,  Yoshikazu Hasegawa ,  Toshio Seto ,  Toshio Osawa

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19 ,  C12P21/02 ,  C07H15/12 ,  C12N15/70

CPC分类号： C07K14/52 ,  A61K38/00 ,  Y10S530/82 ,  Y10S930/12

摘要： A recombinant natural killer cell activating factor is disclosed, preferably having a peptide of the following amino acid sequence in its molecule. The invention provides a cDNA coding for a recombinant natural killer cell activating factor, a expression plasmid involving the cDNA, a host transformed with the plasmid, an antitumor agent containing the recombinant natural killer cell activating factor and a pharmaceutical composition which comprises a pharmacologically effective amount of the antitumor agent and a pharmacologically acceptable carrier.

摘要翻译： 公开了一种重组天然杀伤细胞活化因子，优选在其分子中具有下列氨基酸序列的肽。 本发明提供了编码重组天然杀伤细胞活化因子的cDNA，涉及cDNA的表达质粒，用质粒转化的宿主，含有重组天然杀伤细胞活化因子的抗肿瘤剂和含有药理学有效量的药物组合物 的抗肿瘤剂和药理学上可接受的载体。

公开(公告)号：US5585940A

公开(公告)日：1996-12-17

申请号：US551282

申请日：1995-10-31

申请人： Toshio Seto

发明人： Toshio Seto

IPC分类号： B41J2/52 ,  B41J2/44 ,  H04N1/23 ,  H04N1/40 ,  H04N1/407 ,  H04N1/00

CPC分类号： H04N1/40037 ,  H04N1/407

摘要： In a facsimile apparatus, record density data associated with received data is used to control record density on a paper. At the same time, the emission intensity or pixel-by-pixel emission interval of a light emitting device is controlled to change tonality on a paper pixel by pixel in association with the record density. Hence, even when the record density of received data changes, the present invention prevents the density of a reproduced image from changing and prevents discontinuous lines from being undesirably exaggerated.

摘要翻译： 在传真设备中，使用与接收数据相关联的记录密度数据来控制纸上的记录密度。 同时，控制发光器件的发光强度或逐像素发射间隔，以与记录密度相关联地逐个像素地改变纸张上的色调。 因此，即使接收到的数据的记录密度变化，本发明也能够防止再现图像的浓度变化，防止不连续的行被不期望地夸大。

公开(公告)号：US5185431A

公开(公告)日：1993-02-09

申请号：US392841

申请日：1989-08-11

申请人： Kentaro Yoshimatsu ,  Yukio Ohya ,  Yasushi Shikata ,  Isao Tanaka ,  Yoshikazu Hasegawa ,  Toshio Seto ,  Toshio Osawa

发明人： Kentaro Yoshimatsu ,  Yukio Ohya ,  Yasushi Shikata ,  Isao Tanaka ,  Yoshikazu Hasegawa ,  Toshio Seto ,  Toshio Osawa

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19

CPC分类号： C07K14/52 ,  A61K38/00 ,  Y10S530/82 ,  Y10S930/12

摘要： A recombinant natural killer cell activating factor is disclosed, preferably having a peptide of the following amino acid sequence in its molecule. The invention provides a cDNA coding for a recombinant natural killer cell activating factor, a expression plasmid involving the cDNA, a host transformed with the plasmid, an antitumor agent containing the recombinant natural killer cell activating factor and a pharmaceutical composition which comprises a pharmacologically effective amount of the antitumor agent and a pharmacologically acceptable carrier.