公开(公告)号：US20070134712A1

公开(公告)日：2007-06-14

申请号：US11655316

申请日：2007-01-19

申请人： Hiroyuki Yonekawa ,  Takami Shibazaki ,  Takatomo Satoh ,  Hiroko Sakamoto

发明人： Hiroyuki Yonekawa ,  Takami Shibazaki ,  Takatomo Satoh ,  Hiroko Sakamoto

IPC分类号： C12Q1/68 ,  C12M3/00

CPC分类号： B01L3/50255 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00641 ,  B01J2219/00722 ,  B01L2300/0819 ,  B01L2400/0487 ,  C40B40/06

摘要： The present invention relates to a gene examining apparatus utilizing a computer, the apparatus comprising (1) DNA microarrays in each of which a large number of fine liquid accommodating sections are two-dimensionally arranged so that openings of the fine liquid accommodating sections are located on the same plane, in which each of the liquid accommodating sections can three-dimensionally accommodate a liquid, and in which hybridization reaction occurs in the liquid accommodating section between a target nucleic acid already labeled with an optical marker substance and the nucleic acid probe, and (2) a microscope comprising a stage supporting the DNA microarrays set forth in (1), a temperature regulating section that regulates the temperature of each DNA microarray, and imaging means for picking up an image of an optical signal from the DNA microarray.

摘要翻译： 本发明涉及一种利用计算机的基因检查装置，该装置包括：（1）DNA微阵列，其中大量微细液体容纳部分被二维地布置成使得细液体容纳部分的开口位于 其中每个液体容纳部分可以三维地容纳液体，并且在已经用光学标记物质标记的靶核酸和核酸探针之间的液体容纳部分中发生杂交反应的同一平面，以及 （2）显微镜，其包括支持（1）中所述的DNA微阵列的阶段，调节每个DNA微阵列的温度的温度调节部和用于从DNA微阵列拾取光信号的图像的成像装置。

公开(公告)号：US20050079501A1

公开(公告)日：2005-04-14

申请号：US10502513

申请日：2003-01-24

申请人： Hisashi Koike ,  Tomonori Nagaoka ,  Takatomo Satoh ,  Yoshioki Kaneko ,  Midori Hatanaka ,  Morinao Fukuoka ,  Hiroko Sakamoto ,  Hiroyuki Yonekawa

发明人： Hisashi Koike ,  Tomonori Nagaoka ,  Takatomo Satoh ,  Yoshioki Kaneko ,  Midori Hatanaka ,  Morinao Fukuoka ,  Hiroko Sakamoto ,  Hiroyuki Yonekawa

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/58

CPC分类号： C12Q1/6827 ,  C12Q1/6837 ,  C12Q2565/501 ,  C12Q2561/12 ,  C12Q2527/107

摘要： That invention provides a nucleic acid information detection method which, in a method wherein a target nucleic acid, and probes having a complementary sequence with at least a portion of the target nucleic acid sequence, are contacted with each other in order to form hybrids between the target nucleic acid and the probes, and the amount of signal generated depending on the amount of hybrids is measured in order to detect the information on the target nucleic acid, includes kinetically obtaining data of the signal. Furthermore the invention provides a nucleic acid information detection method which, in a method wherein a perfect matched probe having a perfect complementary sequence with respect to at least part of a target nucleic acid sequence, and one or more types of imperfectly matched probes having at least one part of the perfect matched probe mutated, are contacted with the target nucleic acid in order to hybridize between the target nucleic acid and the perfect matched probe, or the imperfect matched probes, so that the information on the target nucleic acid can be detected based on the difference in binding strength of the hybrids, includes kinetically obtaining data of the signal while changing continuously or stepwise the condition for measuring or detecting the signal from the hybrids.

摘要翻译： 本发明提供了一种核酸信息检测方法，其方法是使靶核酸和与靶核酸序列的至少一部分具有互补序列的探针彼此接触，以形成混合物 靶核酸和探针，并且测量根据杂交体量产生的信号量，以便检测关于靶核酸的信息，包括动态获得信号的数据。 此外，本发明提供了一种核酸信息检测方法，其方法中，其中完全匹配的探针具有相对于目标核酸序列的至少一部分具有完全互补序列，以及一种或多种不完全匹配的探针，其至少具有至少 突变的完美匹配探针的一部分与目标核酸接触以便在靶核酸和完全匹配的探针之间进行杂交，或者不完全匹配的探针，使得可以基于目标核酸的信息被检测 关于混合物的结合强度的差异，包括动态获得信号的数据，同时连续或逐步地改变用于测量或检测来自杂交体的信号的条件。

公开(公告)号：US07617047B2

公开(公告)日：2009-11-10

申请号：US11440036

申请日：2006-05-25

申请人： Hiroko Sakamoto ,  Yosuke Nitta ,  Masumi Sato ,  Keisuke Otsuka

发明人： Hiroko Sakamoto ,  Yosuke Nitta ,  Masumi Sato ,  Keisuke Otsuka

IPC分类号： G01C21/30 ,  G01C21/32

CPC分类号： G09B29/00 ,  G06F17/30241

摘要： A map information system is provided which includes an electronic pen which reads a dot pattern in a form where map images are shown, to output handwriting information, and a processing unit including an association module which associates the output handwriting information with one of the map images where the handwriting information is written and stores it in a storage unit, a search module which searches for the associated handwriting information and map image using information to specify the map image as a search key, a pattern assignment module which when acquiring print request information including information to specify the map images to be printed, newly assigns a dot pattern, and an output instruction module which issues an output instruction so as to cause an output unit to visually output data including the retrieved associated handwriting information and map image and the newly assigned dot pattern.

摘要翻译： 提供了一种地图信息系统，其包括以绘制地图图像的形式读取点阵图形以输出手写信息的电子笔，以及包括关联模块的处理单元，该关联模块将输出的手写信息与其中一个地图图像相关联 写入手写信息并将其存储在存储单元中的搜索模块，使用用于指定地图图像作为搜索关键字的信息来搜索相关联的手写信息和地图图像的搜索模块，当获取包括 用于指定要打印的地图图像的信息，新分配点图案和发出输出指令的输出指令模块，以使得输出单元可视地输出包括检索到的相关联的手写信息和地图图像的数据，以及新分配 点图案。

公开(公告)号：US20070015223A1

公开(公告)日：2007-01-18

申请号：US11440675

申请日：2006-05-25

申请人： Hiromi Sanuki ,  Hiroko Sakamoto ,  Morinao Fukuoka

发明人： Hiromi Sanuki ,  Hiroko Sakamoto ,  Morinao Fukuoka

IPC分类号： G01N33/542 ,  G01N33/558

CPC分类号： G01N33/557 ,  G01N33/54306 ,  G01N33/581

摘要： An object of the invention is to provide a quick, easy, and highly-sensitive method of detecting a substance to be analyzed, and to provide a method of supporting the analysis results by quantitativeness even if the amount of samples to be handled is a very small amount. The invention is a method of detecting a substance to be analyzed, including: measuring a intensity of a signal derived from a labeled substance to be analyzed, in a time series during an increase in the signal intensity; and representing the signal intensity by a function of time, and using the quantitative value of the signal intensity for when the slope of an approximated line of the measured signal intensity is within a range between 0.5 and 1.5 times the slope of the approximated line of the previously measured signal intensity.

摘要翻译： 本发明的目的是提供一种检测待分析物质的快速，容易和高灵敏度的方法，并且提供一种通过定量分析支持分析结果的方法，即使要处理的样品量非常多 小数量。 本发明是检测待分析物质的方法，包括：在信号强度增加期间以时间序列测量从待分析标记物质得到的信号的强度; 并且通过时间函数表示信号强度，并且当所测量的信号强度的近似行的斜率在所述信号强度的近似行的斜率的0.5和1.5倍之间的范围内时，使用信号强度的定量值 先前测量的信号强度。

公开(公告)号：US20070129887A1

公开(公告)日：2007-06-07

申请号：US11440036

申请日：2006-05-25

申请人： Hiroko Sakamoto ,  Yosuke Nitta ,  Masumi Sato ,  Keisuke Otsuka

发明人： Hiroko Sakamoto ,  Yosuke Nitta ,  Masumi Sato ,  Keisuke Otsuka

IPC分类号： G01C21/32

CPC分类号： G09B29/00 ,  G06F17/30241

摘要： A map information system is provided which includes an electronic pen which reads a dot pattern in a form where map images are shown, to output handwriting information, and a processing unit including an association module which associates the output handwriting information with one of the map images where the handwriting information is written and stores it in a storage unit, a search module which searches for the associated handwriting information and map image using information to specify the map image as a search key, a pattern assignment module which when acquiring print request information including information to specify the map images to be printed, newly assigns a dot pattern, and an output instruction module which issues an output instruction so as to cause an output unit to visually output data including the retrieved associated handwriting information and map image and the newly assigned dot pattern.

摘要翻译： 提供了一种地图信息系统，其包括以绘制地图图像的形式读取点阵图形以输出手写信息的电子笔，以及包括关联模块的处理单元，该关联模块将输出的手写信息与其中一个地图图像相关联 写入手写信息并将其存储在存储单元中的搜索模块，使用用于指定地图图像作为搜索关键字的信息来搜索相关联的手写信息和地图图像的搜索模块，当获取包括 用于指定要打印的地图图像的信息，新分配点图案和发出输出指令的输出指令模块，以使得输出单元可视地输出包括检索到的相关联的手写信息和地图图像的数据，以及新分配的 点图案。