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    ROTIGOTINE STABILIZATION METHOD
    1.
    发明申请
    ROTIGOTINE STABILIZATION METHOD 有权

    公开(公告)号：US20220117934A1

    公开(公告)日：2022-04-21

    申请号：US17428699

    申请日：2020-01-23

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Takao KUROKAWA ,  Hiroyuki ARAKI ,  Kimiko KOMATANI

    IPC: A61K31/381 ,  A61K9/70 ,  A61K47/32 ,  A61K47/06

    Abstract: The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.

    ROTIGOTINE-CONTAINING PATCH
    2.
    发明申请
    ROTIGOTINE-CONTAINING PATCH 审中-公开

    公开(公告)号：US20200306203A1

    公开(公告)日：2020-10-01

    申请号：US16954627

    申请日：2018-12-14

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Hiroyuki ARAKI ,  Yuka TAKAGI ,  Yoko FUJIWARA ,  Hiroaki KOBAYASHI ,  Takao KUROKAWA

    IPC: A61K9/70 ,  A61K31/381

    Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, andin the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.

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