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公开(公告)号：US20160221907A1
公开(公告)日：2016-08-04
申请号：US15071222
申请日：2016-03-16
发明人： Min LI , Juxian SONG , Chuanbin YANG , Yu ZENG , Sandeep MALAMPATI , Hongjie ZHANG
IPC分类号： C07C49/223 , C07C49/255 , A61K9/00 , C07C49/248 , A61K31/12 , C07C49/235
CPC分类号： C07C49/223 , A61K9/0053 , A61K31/12 , C07C49/235 , C07C49/248 , C07C49/255
摘要： The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.
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2.发明申请MTOR-independent activator of TFEB for autophagy enhancement and uses thereof 有权TFEB的MTOR非依赖性激活剂用于自噬增强及其用途公开(公告)号：US20150250741A1
公开(公告)日：2015-09-10
申请号：US14609438
申请日：2015-01-30
发明人： Min LI , Juxian SONG , Yu ZENG , Liangfeng LIU
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： The present invention relates to a composition comprising an autophagy enhancement compound. Small molecules that are able to enhance autophagy and lysosome biogenesis by activating the gene TFEB which can prevent the accumulation of toxic protein aggregates in treating neurodegenerative diseases are disclosed.
摘要翻译： 本发明涉及包含自噬增强化合物的组合物。 公开了能够通过激活基因TFEB来增强自噬和溶酶体生物发生的小分子，其可以防止毒性蛋白质聚集体在治疗神经变性疾病中的积累。
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3.发明申请公开(公告)号：US20200000743A1
公开(公告)日：2020-01-02
申请号：US16455787
申请日：2019-06-28
发明人： Min LI , Juxian SONG , Sandeep MALAMPATI
摘要： The present invention relates to a method of use of a composition comprising an autophagy enhancement compound for treating neurodegenerative diseases. In particular, the said composition is used to treat the neural condition of synaptic dysfunction. Such neurodegenerative diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease, Frontotemporal dementia with parkinsonism-17 (FTDP-17), Pick disease (PiD), Progressive supranuclear palsy (PSP), Corticobasal degeneration (CBD) and Cerebral amyloid angiopathy.
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