公开(公告)号：US12180140B2

公开(公告)日：2024-12-31

申请号：US18390545

申请日：2023-12-20

Applicant: Hongene Biotech Corporation

Inventor： Gaomai Yang ,  Min Xie ,  Hongrong Yang ,  Shengdong Wang ,  Aldrich N. K. Lau ,  Ruiming Zou ,  David Yu

IPC: C07C237/22 ,  C07C231/00 ,  C07C233/59 ,  C07H1/00 ,  C07H21/00

Abstract: The present disclosure relates to methods and compounds for liquid phase oligonucleotide synthesis employing the use of small molecules with lipophilic groups. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the compounds described herein are also provided.