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公开(公告)号：US08877756B2
公开(公告)日：2014-11-04
申请号：US12689273
申请日：2010-01-19
申请人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
IPC分类号： A61K31/5025 , C07D519/00 , C07D475/08 , A61P29/00 , A61P1/00 , A61P35/00
CPC分类号： C07D475/08 , C07D519/00
摘要： The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also relates to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病和癌症的新型蝶啶。 本发明还涉及含有这些化合物的药物组合物。
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公开(公告)号：US20070287704A1
公开(公告)日：2007-12-13
申请号：US11751917
申请日：2007-05-22
申请人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/525 , C07D475/02
CPC分类号： C07D475/08 , C07D519/00
摘要： The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also relates to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病和癌症的新型蝶啶。 本发明还涉及含有这些化合物的药物组合物。
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公开(公告)号：US07674788B2
公开(公告)日：2010-03-09
申请号：US11751917
申请日：2007-05-22
申请人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Domnic Martyres , Juergen Mack , Rolf Goeggel , Birgit Jung , Peter Nickolaus
IPC分类号： C07D475/08 , A61K31/5375 , A61K31/505 , A61K31/541 , A61P35/00 , A61P29/00 , C07D413/04 , C07D417/04 , C07D475/06 , C07C259/12 , C07C211/35
CPC分类号： C07D475/08 , C07D519/00
摘要： The invention relates to new pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system and cancers. This invention also relates to pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病和癌症的新型蝶啶。 本发明还涉及含有这些化合物的药物组合物。
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公开(公告)号：US20100234347A1
公开(公告)日：2010-09-16
申请号：US12301861
申请日：2007-05-15
申请人： Horst Dollinger , Domnic Martyres , Rolf Goeggel , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Domnic Martyres , Rolf Goeggel , Birgit Jung , Peter Nickolaus
IPC分类号： A61K31/397 , C07D475/08 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61P25/16 , A61P35/00 , A61P35/02
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines of formula (1), suitable for the treatment of airway or gastrointestinal complaints or diseases, inflammatory diseases of the joints, the skin or eyes, diseases of the peripheral or central nervous systems or cancerous diseases and pharmaceutical compositions comprising said compounds.
摘要翻译： 本发明涉及适用于治疗气道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌性疾病的药物（1）的新型蝶啶和包含 所述化合物。
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公开(公告)号：US07723381B2
公开(公告)日：2010-05-25
申请号：US11409482
申请日：2006-04-21
申请人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
发明人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
IPC分类号： A61K31/343 , C07D307/78
CPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译： 适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛炎症性疾病的式1化合物及其异构体及其药理学上可接受的盐，对映异构体，外消旋体，水合物或溶剂化物 的外周或中枢神经系统或癌症，以及含有这些化合物的药物组合物。
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公开(公告)号：US20100190767A1
公开(公告)日：2010-07-29
申请号：US12753365
申请日：2010-04-02
申请人： Ralf ANDERSKEWITZ , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
发明人： Ralf ANDERSKEWITZ , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
IPC分类号： A61K31/397 , A61K31/4178 , A61K31/403 , A61K31/454 , A61K31/506 , A61K31/5377 , A61P11/06 , A61P11/08 , A61P11/00 , A61P1/00
CPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
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公开(公告)号：US20060258861A1
公开(公告)日：2006-11-16
申请号：US11409482
申请日：2006-04-21
申请人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
发明人： Ralf Anderskewitz , Horst Dollinger , Rolf Goeggel , Birgit Jung , Joerg Kley , Juergen Mack , Peter Nickolaus , Rainer Walter
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4184 , C07D403/02 , C07D417/02 , C07D413/02
CPC分类号： C07D209/34 , C07D307/83 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译： 适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛炎症性疾病的式1化合物及其异构体及其药理学上可接受的盐，对映异构体，外消旋体，水合物或溶剂化物 的外周或中枢神经系统或癌症，以及含有这些化合物的药物组合物。
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公开(公告)号：US08754073B2
公开(公告)日：2014-06-17
申请号：US12738344
申请日：2008-10-16
申请人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
发明人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
IPC分类号： C07D495/04 , A61K31/519 , A61P29/00 , A61P11/06 , A61P25/28
CPC分类号： C07D495/04 , C07D519/00
摘要： Piperidinodihydrothienopyrimidines of formula 1 wherein X is SO or SO2 (preferably SO), and R1, R2, R3, and R4 may have the meanings given in the disclosure and claims, pharmacologically acceptable salts thereof, and pharmaceutical compositions containing these compounds. These piperidinodihydrothienopyrimidines are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancers.
摘要翻译： 其中X为SO或SO 2（优选为SO）的R1为吡啶并二氢噻吩并嘧啶，R1，R2，R3和R4可具有本公开和权利要求书中给出的含义，其药理学上可接受的盐，以及含有这些化合物的药物组合物。 这些哌啶二氢噻吩并嘧啶适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。
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公开(公告)号：US09115142B2
公开(公告)日：2015-08-25
申请号：US14134367
申请日：2013-12-19
申请人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
发明人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00
CPC分类号： C07D495/04 , A61K31/519 , A61K2300/00
摘要： Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
摘要翻译： 式1的二氢噻吩并嘧啶亚砜，其中X是SO或SO 2，R 1是H或C 1-6 - 烷基，R 2是H或如本文所公开的有机基团，并且R 3是任选取代的单或双环不饱和的，部分饱和的或饱和的 杂环或任选取代的单环或双环杂芳基及其药理学上可接受的盐，以及含有这些化合物的药物组合物。 这些二氢噻吩并嘧啶亚砜适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。
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公开(公告)号：US08637519B2
公开(公告)日：2014-01-28
申请号：US12738429
申请日：2008-10-16
申请人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
发明人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
IPC分类号： C07D495/04 , A61K31/519 , A61P11/06 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K2300/00
摘要： Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
摘要翻译： 式1的二氢噻吩并嘧啶亚砜，其中X是SO或SO 2，R 1是H或C 1-6 - 烷基，R 2是H或如本文所公开的有机基团，并且R 3是任选取代的单或双环不饱和的，部分饱和的或饱和的 杂环或任选取代的单环或双环杂芳基及其药理学上可接受的盐，以及含有这些化合物的药物组合物。 这些二氢噻吩并嘧啶亚砜适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。
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