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公开(公告)号：US20110275593A1
公开(公告)日：2011-11-10
申请号：US13100439
申请日：2011-05-04
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K31/736 , A61K9/0048 , A61K9/08 , A61K45/06
摘要： The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
摘要翻译： 本发明涉及适用于药物递送的粘度稳定的眼用制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含二醇醇，例如山梨醇和任选的药学上可接受的二价阳离子盐如氯化镁。
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公开(公告)号：US08685945B2
公开(公告)日：2014-04-01
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/70
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US08536325B2
公开(公告)日：2013-09-17
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US20120142630A1
公开(公告)日：2012-06-07
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736 , A61P27/02 , C08B37/00
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US20110008276A1
公开(公告)日：2011-01-13
申请号：US12831890
申请日：2010-07-07
IPC分类号： A61K31/765 , A61P27/02
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/008 , C11D3/222 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
摘要翻译： 本发明涉及包含环氧乙烷环氧丁烷和半乳甘露聚糖如瓜尔胶的组合物。 组合物特别适用于眼科应用，如隐形眼镜消毒和再湿润。 还考虑了使用本发明的组合物治疗干眼症的方法。
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公开(公告)号：US09175249B2
公开(公告)日：2015-11-03
申请号：US12831890
申请日：2010-07-07
IPC分类号： A61K31/765 , C11D3/48 , A61K9/00 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/00 , C11D3/22
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/008 , C11D3/222 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
摘要翻译： 本发明涉及包含环氧乙烷环氧丁烷和半乳甘露聚糖如瓜尔胶的组合物。 组合物特别适用于眼科应用，如隐形眼镜消毒和再湿润。 还考虑了使用本发明的组合物治疗干眼症的方法。
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公开(公告)号：US20120070402A1
公开(公告)日：2012-03-22
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US06995123B2
公开(公告)日：2006-02-07
申请号：US10738202
申请日：2003-12-17
CPC分类号： C11D1/10 , C11D1/88 , C11D3/0078 , Y10S514/912
摘要： Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
摘要翻译： 描述隐形眼镜的清洁组合物。 该组合物包含多功能阴离子表面活性剂，其包括至少两个亲水解离头基团。 所描述的多官能表面活性剂（例如LED 3A）具有表面活性和螯合性质，并且已被发现在去除隐形眼镜中的蛋白沉积物方面特别有效。
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9.发明授权Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs 有权使用合成无机纳米粒子作为眼科和耳用药物的载体公开(公告)号：US08257745B2
公开(公告)日：2012-09-04
申请号：US13186108
申请日：2011-07-19
IPC分类号： A61K9/14 , A61K38/18 , A61P27/06 , A61P25/00 , A61P31/00 , A61P29/00 , A61P37/08 , A61P37/02 , B82Y5/00
CPC分类号： A61K31/575 , A61K9/0012 , A61K9/0048 , A61K47/02
摘要： The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.
摘要翻译： 描述了在眼科和耳用药物组合物中使用无机材料的纳米颗粒（例如合成蒙脱石粘土）。 纳米颗粒被用作眼科和耳用药物的生物惰性载体或贮库。 纳米颗粒也可用于改变组合物的流变性质，以便增强组合物的粘度或流动特性和/或增加组合物在眼睛或耳朵中的保留时间。
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公开(公告)号：US20160338952A1
公开(公告)日：2016-11-24
申请号：US15228589
申请日：2016-08-04
CPC分类号： A61K9/107 , A61K9/0048 , B01F17/0028 , B01F17/0064 , B01F17/0085
摘要： The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
摘要翻译： 本发明涉及眼用乳液。 该乳液具有促进乳液中小油滴的稳定性的成分的独特组合。 乳剂还包括有助于将脂质递送到眼表面的粘膜粘附聚合物。
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