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公开(公告)号：US20110275593A1
公开(公告)日：2011-11-10
申请号：US13100439
申请日：2011-05-04
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K31/736 , A61K9/0048 , A61K9/08 , A61K45/06
摘要： The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
摘要翻译： 本发明涉及适用于药物递送的粘度稳定的眼用制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含二醇醇，例如山梨醇和任选的药学上可接受的二价阳离子盐如氯化镁。
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公开(公告)号：US08536325B2
公开(公告)日：2013-09-17
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US20120142630A1
公开(公告)日：2012-06-07
申请号：US13396305
申请日：2012-02-14
IPC分类号： A61K31/736 , A61P27/02 , C08B37/00
CPC分类号： A61K36/48 , A61K9/0048 , A61K47/36 , C08B37/0003 , C08B37/0096
摘要： The present invention relates to processes for purifying guar comprising combining borate and guar in an aqueous solution and treating the aqueous solution with an organic solvent to induce precipitation of purified guar. Another embodiment of the present invention is directed to ophthalmic formulations comprising purified guar produced by the processes described.
摘要翻译： 本发明涉及净化瓜尔胶的方法，包括在水溶液中混合硼酸盐和瓜尔胶，并用有机溶剂处理水溶液以诱导纯化的瓜尔胶的沉淀。 本发明的另一个实施方案涉及包含通过所述方法制备的纯化瓜尔胶的眼用制剂。
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公开(公告)号：US20110008276A1
公开(公告)日：2011-01-13
申请号：US12831890
申请日：2010-07-07
IPC分类号： A61K31/765 , A61P27/02
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/008 , C11D3/222 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
摘要翻译： 本发明涉及包含环氧乙烷环氧丁烷和半乳甘露聚糖如瓜尔胶的组合物。 组合物特别适用于眼科应用，如隐形眼镜消毒和再湿润。 还考虑了使用本发明的组合物治疗干眼症的方法。
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公开(公告)号：US08685945B2
公开(公告)日：2014-04-01
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/70
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US09175249B2
公开(公告)日：2015-11-03
申请号：US12831890
申请日：2010-07-07
IPC分类号： A61K31/765 , C11D3/48 , A61K9/00 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/00 , C11D3/22
CPC分类号： C11D3/48 , A61K9/0048 , A61K31/736 , A61K31/77 , A61K47/34 , A61K47/36 , C11D1/008 , C11D3/222 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compositions comprising ethyleneoxide butyleneoxide and a galactomannan such as guar. The compositions are particularly well suited for ophthalmic applications such as contact lens disinfection and rewetting. Methods for the treatment of dry eye using the compositions of the present invention are also contemplated.
摘要翻译： 本发明涉及包含环氧乙烷环氧丁烷和半乳甘露聚糖如瓜尔胶的组合物。 组合物特别适用于眼科应用，如隐形眼镜消毒和再湿润。 还考虑了使用本发明的组合物治疗干眼症的方法。
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公开(公告)号：US20120070402A1
公开(公告)日：2012-03-22
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
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公开(公告)号：US08999312B2
公开(公告)日：2015-04-07
申请号：US13151991
申请日：2011-06-02
IPC分类号： C09K13/00 , A61L2/00 , C09K3/00 , A61L9/01 , C11D3/48 , A61L12/12 , A61L12/14 , C11D1/00 , C11D3/00 , C11D3/39
CPC分类号： A01N25/30 , A01N59/00 , A61L12/124 , A61L12/142 , C11D1/008 , C11D3/0078 , C11D3/3947 , C11D3/48
摘要： The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful, for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention.
摘要翻译： 公开了在用于改性隐形眼镜和其它医疗装置的表面的药物组合物中使用聚（氧丁烯） - 聚（氧乙烯） - 聚（氧丁烯） - 嵌段共聚物。 本发明部分地基于以下发现，即这类化合物在润湿疏水性表面（例如硅酮水凝胶隐形眼镜和其它类型的眼科镜片的表面）中特别有效，但是当与 一种基于过氧化物的隐形眼镜消毒方案。 这样的化合物也可用于清洁目的。 因此，作为用于消毒隐形眼镜的过氧化物基组合物中的化合物作为表面活性剂的使用是本发明的优选实施方案。
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9.发明申请公开(公告)号：US20110300019A1
公开(公告)日：2011-12-08
申请号：US13151991
申请日：2011-06-02
CPC分类号： A01N25/30 , A01N59/00 , A61L12/124 , A61L12/142 , C11D1/008 , C11D3/0078 , C11D3/3947 , C11D3/48
摘要： The use of poly(oxybutylene)-poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful, for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses, but do not induce foaming when used in conjunction with a peroxide-based contact lens disinfection regimen. Such compounds may also be useful for cleaning purposes. The use of the compounds as surfactants in peroxide-based compositions for disinfecting contact lenses therefore represents a preferred embodiment of the present invention.
摘要翻译： 公开了在用于改性隐形眼镜和其它医疗装置的表面的药物组合物中使用聚（氧丁烯） - 聚（氧乙烯） - 聚（氧丁烯） - 嵌段共聚物。 本发明部分地基于以下发现，即这类化合物在润湿疏水性表面（例如硅酮水凝胶隐形眼镜和其它类型的眼科镜片的表面）中特别有效，但是当与 一种基于过氧化物的隐形眼镜消毒方案。 这样的化合物也可用于清洁目的。 因此，作为用于消毒隐形眼镜的过氧化物基组合物中的化合物作为表面活性剂的使用是本发明的优选实施方案。
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公开(公告)号：US20110151017A1
公开(公告)日：2011-06-23
申请号：US12972095
申请日：2010-12-17
申请人： Howard Allen Ketelson , Roya Nicole Borazjani , Nissanke L. Dassanayake , James W. Davis , Thomas Christopher Carey , John C. Baker
发明人： Howard Allen Ketelson , Roya Nicole Borazjani , Nissanke L. Dassanayake , James W. Davis , Thomas Christopher Carey , John C. Baker
CPC分类号： A61K33/22 , A61K9/0048 , A61K33/40 , A61K47/02 , A61K47/08 , A61L12/124 , C11D3/0078 , C11D3/3947 , A61K2300/00
摘要： The present invention relates to ophthalmic solutions with antimicrobial activity. The solutions have an antimicrobial compound such as hydrogen peroxide and a boron compound. In one embodiment, the solutions contain a boron compound such as sodium borate that provides antimicrobial activity in addition to that of hydrogen peroxide, particularly during periods following disinfection and neutralization of such solutions. This additional activity reduces the likelihood of microbial growth in contact lens disinfection applications that neutralize hydrogen peroxide.
摘要翻译： 本发明涉及具有抗菌活性的眼用溶液。 该溶液具有抗菌化合物如过氧化氢和硼化合物。 在一个实施方案中，溶液含有硼化合物，例如硼酸钠，除了过氧化氢以外还提供抗微生物活性，特别是在消毒和中和这些溶液之后的期间。 这种额外的活性降低了中和过氧化氢的隐形眼镜消毒应用中微生物生长的可能性。
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