-
公开(公告)号：US08318144B2
公开(公告)日：2012-11-27
申请号：US11953654
申请日：2007-12-10
CPC分类号： C11D3/0078 , A45C11/005 , A61F2/1691 , B65D81/22 , C11D1/008 , C11D3/3707
摘要： The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.
摘要翻译： 公开了在用于改性隐形眼镜和其它医疗装置的表面的药物组合物中使用聚（氧乙烯） - 聚（氧丁烯）嵌段共聚物。 本发明部分地基于以下发现：这类化合物特别有效地润湿疏水表面，例如硅酮水凝胶隐形眼镜和其它类型的眼科镜片的表面。 这些化合物也可用于清洁目的。 因此，作为用于治疗隐形眼镜的各种类型的组合物中的化合物作为表面活性剂的使用是本发明的优选实施方案。
-
公开(公告)号：US20110275593A1
公开(公告)日：2011-11-10
申请号：US13100439
申请日：2011-05-04
IPC分类号： A61K31/736 , A61P27/04
CPC分类号： A61K31/736 , A61K9/0048 , A61K9/08 , A61K45/06
摘要： The present invention relates to viscosity stabilized ophthalmic formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a diol alcohol such as sorbitol and, optionally, a pharmaceutically acceptable divalent cation salt such as magnesium chloride.
摘要翻译： 本发明涉及适用于药物递送的粘度稳定的眼用制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含二醇醇，例如山梨醇和任选的药学上可接受的二价阳离子盐如氯化镁。
-
公开(公告)号：US07468344B2
公开(公告)日：2008-12-23
申请号：US11839932
申请日：2007-08-16
CPC分类号： A61L12/08 , A61L12/142 , A61L12/145 , C11D3/0078 , C11D3/3719 , C11D3/3773 , Y10S514/839 , Y10T428/31725
摘要： The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosthetics.
摘要翻译： 描述了使用NIPAM聚合物来预防或减少医疗装置表面上蛋白沉积物的形成。 本发明特别涉及减少隐形眼镜和其它医疗假体表面上蛋白质的吸附。
-
4.发明授权公开(公告)号：US07344725B2
公开(公告)日：2008-03-18
申请号：US10989630
申请日：2004-11-16
CPC分类号： A61K33/40 , A01N59/00 , Y10S514/912 , Y10S514/915 , A01N25/22 , A01N2300/00
摘要： The use of inorganic nanoparticles to stabilize aqueous hydrogen peroxide solutions is described. The preferred nanoparticles are formed from clays. The use of nanoparticles formed from synthetic smectite clays is particularly preferred. The stabilized hydrogen peroxide solutions may be utilized for various purposes, but are particularly useful as contact lens disinfecting solutions.
摘要翻译： 描述了使用无机纳米颗粒来稳定过氧化氢水溶液。 优选的纳米颗粒由粘土形成。 使用由合成蒙皂石粘土形成的纳米颗粒是特别优选的。 稳定的过氧化氢溶液可用于各种目的，但作为隐形眼镜消毒溶液特别有用。
-
公开(公告)号：US09574160B2
公开(公告)日：2017-02-21
申请号：US12947614
申请日：2010-11-16
CPC分类号： C11D3/0078 , A45C11/005 , A61F2/1691 , B65D81/22 , C11D1/008 , C11D3/3707
摘要： The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.
摘要翻译： 公开了在用于改性隐形眼镜和其它医疗装置的表面的药物组合物中使用聚（氧乙烯） - 聚（氧丁烯）嵌段共聚物。 本发明部分地基于以下发现：这类化合物特别有效地润湿疏水表面，例如硅酮水凝胶隐形眼镜和其它类型的眼科镜片的表面。 这些化合物也可用于清洁目的。 因此，作为用于治疗隐形眼镜的各种类型的组合物中的化合物作为表面活性剂的使用是本发明的优选实施方案。
-
公开(公告)号：US20160338952A1
公开(公告)日：2016-11-24
申请号：US15228589
申请日：2016-08-04
CPC分类号： A61K9/107 , A61K9/0048 , B01F17/0028 , B01F17/0064 , B01F17/0085
摘要： The present invention is directed to an ophthalmic emulsion. The emulsion has a unique combination of ingredients that promotes the stability of small oil droplets within the emulsion. The emulsion also includes a mucoadhesive polymer that aid in delivering a lipid to the ocular surface.
摘要翻译： 本发明涉及眼用乳液。 该乳液具有促进乳液中小油滴的稳定性的成分的独特组合。 乳剂还包括有助于将脂质递送到眼表面的粘膜粘附聚合物。
-
7.发明授权Interaction control of cationic biocides using labile anionic polyelectrolytes 有权使用不稳定阴离子聚电解质的阳离子杀生物剂的相互作用控制公开(公告)号：US09040510B2
公开(公告)日：2015-05-26
申请号：US12410513
申请日：2009-03-25
IPC分类号： A61L12/14
CPC分类号： A61L12/143 , A61L12/14 , A61L12/145
摘要： Methods of inhibiting the uptake of cationic biocides into medical devices such as contact lenses and implants are described. Methods of stabilizing emulsions containing cationic biocides are also described. In particular, the present invention provides for the use of polymers acting as labile anionic polyelectrolytes to reversibly bind cationic biocides. The reversible binding can reduce the deleterious effects of cationic biocides while maintaining biocidal activity. Preferred polymers include galactomannan and polyvinyl alcohol.
摘要翻译： 描述了抑制阳离子杀生物剂吸收到医疗装置如隐形眼镜和植入物中的方法。 还描述了稳定含有阳离子杀生物剂的乳液的方法。 特别地，本发明提供了用作不稳定阴离子聚电解质的聚合物可逆地结合阳离子杀生物剂的用途。 可逆结合可以降低阳离子杀生物剂的有害作用，同时保持杀生物活性。 优选的聚合物包括半乳甘露聚糖和聚乙烯醇。
-
公开(公告)号：US20110059039A1
公开(公告)日：2011-03-10
申请号：US12947614
申请日：2010-11-16
IPC分类号： A61K31/765 , A61P27/02 , A61P31/00
CPC分类号： C11D3/0078 , A45C11/005 , A61F2/1691 , B65D81/22 , C11D1/008 , C11D3/3707
摘要： The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.
摘要翻译： 公开了在用于改性隐形眼镜和其它医疗装置的表面的药物组合物中使用聚（氧乙烯） - 聚（氧丁烯）嵌段共聚物。 本发明部分地基于以下发现：这类化合物特别有效地润湿疏水表面，例如硅酮水凝胶隐形眼镜和其它类型的眼科镜片的表面。 这些化合物也可用于清洁目的。 因此，作为用于治疗隐形眼镜的各种类型的组合物中的化合物作为表面活性剂的使用是本发明的优选实施方案。
-
公开(公告)号：US20080220149A1
公开(公告)日：2008-09-11
申请号：US12127050
申请日：2008-05-27
IPC分类号： B05D5/00
CPC分类号： A61L12/08 , A61L12/142 , A61L12/145 , C11D3/0078 , C11D3/3719 , C11D3/3773 , Y10S514/839 , Y10T428/31725
摘要： The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosthetics.
摘要翻译： 描述了使用NIPAM聚合物来预防或减少医疗装置表面上蛋白沉积物的形成。 本发明特别涉及减少隐形眼镜和其它医疗假体表面上蛋白质的吸附。
-
公开(公告)号：US08685945B2
公开(公告)日：2014-04-01
申请号：US13302439
申请日：2011-11-22
IPC分类号： A61K31/70
CPC分类号： A61K47/26 , A61K9/0048 , A61K31/08 , A61K31/736 , A61K47/02 , A61K47/10 , A61K47/36
摘要： The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.
摘要翻译： 本发明涉及适于药物递送的人造泪液制剂和眼用制剂。 制剂包含半乳甘露聚糖，例如瓜尔胶或羟丙基瓜尔胶，硼酸盐如硼酸。 制剂还包含干扰半乳甘露聚糖和硼酸盐的交联的顺式二醇如山梨糖醇。 任选地，制剂基本上不含二价阳离子。
-
-
-
-
-
-
-
-
-
搜索结果
33 条记录 (耗时 0.015 秒)