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公开(公告)号：US08034959B2
公开(公告)日：2011-10-11
申请号：US12396266
申请日：2009-03-02
申请人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David John King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David John King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
IPC分类号： C07D487/02 , A61K39/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：US07498302B2
公开(公告)日：2009-03-03
申请号：US11133970
申请日：2005-05-20
申请人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhi-Hong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Elaine Boyd , Thomas J. Lobl
IPC分类号： A61K38/00 , C07D487/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：US06989452B2
公开(公告)日：2006-01-24
申请号：US10161233
申请日：2002-05-31
申请人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P. C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： C07D487/00 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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公开(公告)号：USRE41252E1
公开(公告)日：2010-04-20
申请号：US12126731
申请日：2008-05-23
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunder , Irina Astafieva , Valeri Martichonok
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunder , Irina Astafieva , Valeri Martichonok
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明连接臂的前药和缀合物。
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公开(公告)号：US07977465B2
公开(公告)日：2011-07-12
申请号：US12397834
申请日：2009-03-04
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： C07K16/00 , C12P21/08 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：US07507420B2
公开(公告)日：2009-03-24
申请号：US11224580
申请日：2005-09-12
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhi-Hong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：US20090175888A1
公开(公告)日：2009-07-09
申请号：US12396266
申请日：2009-03-02
申请人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
发明人： Howard P. Ng , Zhihong Li , Danny P.C. McGee , Oliver L. Saunders , Guoxian Wu , David J. King , Valeri Martichonok , Sharon Boyd , Thomas J. Lobl
IPC分类号： A61K39/395 , C07D487/04 , A61P35/00
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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公开(公告)号：US07087600B2
公开(公告)日：2006-08-08
申请号：US10161234
申请日：2002-05-31
申请人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P. C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： A61K31/535 , A61K31/407 , C07D487/02
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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公开(公告)号：US07129261B2
公开(公告)日：2006-10-31
申请号：US10160972
申请日：2002-05-31
申请人： Howard P. Ng , Danny P.C. McGee , Oliver L. Saunders , Valeri Martichonok , Guoxian Wu , Zhihong Li , Geoffrey T. Yarranton
发明人： Howard P. Ng , Danny P.C. McGee , Oliver L. Saunders , Valeri Martichonok , Guoxian Wu , Zhihong Li , Geoffrey T. Yarranton
IPC分类号： A61K31/40 , C07D487/04
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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10.发明申请公开(公告)号：US20090209734A1
公开(公告)日：2009-08-20
申请号：US12397834
申请日：2009-03-04
申请人： Howard P. Ng , Danny P.C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
发明人： Howard P. Ng , Danny P.C. McGee , Guoxian Wu , Jimmie Moore , Zhihong Li , Sanjeev Gangwar , Oliver L. Saunders , Irina Astafieva
IPC分类号： C07K16/00 , C07D487/04
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12 , C07D405/14 , C07D487/04 , C07D487/10 , C07F7/1804 , C07F9/6561
摘要： The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
摘要翻译： 本发明提供了作为有效的细胞毒素的杜卡霉素的类似物。 还提供了在体内被切割的肽基和二硫键接头。 连接体可用于形成本发明的细胞毒素的前药和缀合物以及其它诊断和治疗部分。 本发明提供了杜卡霉素类似物与本发明的连接臂的前药和缀合物。
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