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1.发明授权公开(公告)号：US07311689B2
公开(公告)日：2007-12-25
申请号：US10642638
申请日：2003-08-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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2.发明授权公开(公告)号：US07935071B2
公开(公告)日：2011-05-03
申请号：US11960145
申请日：2007-12-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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公开(公告)号：US08603021B2
公开(公告)日：2013-12-10
申请号：US13098853
申请日：2011-05-02
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US20110208106A1
公开(公告)日：2011-08-25
申请号：US13098853
申请日：2011-05-02
IPC分类号： A61M1/16
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US06890315B1
公开(公告)日：2005-05-10
申请号：US09618759
申请日：2000-07-18
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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6.发明申请公开(公告)号：US20080097273A1
公开(公告)日：2008-04-24
申请号：US11960145
申请日：2007-12-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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公开(公告)号：US07175809B2
公开(公告)日：2007-02-13
申请号：US10801059
申请日：2004-03-16
申请人： Mark Gelfand , John O'Mahony , Howard R. Levin
发明人： Mark Gelfand , John O'Mahony , Howard R. Levin
CPC分类号： A61M1/34 , A61M1/341 , A61M1/36 , A61M2205/3303 , A61M2205/3306 , A61M2205/3331 , A61M2205/3375 , A61M2205/50 , A61M2230/205 , A61M2230/005
摘要： A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures an oxygen level in the venous blood. The oxygen blood level is used to detect when hypotension is about to occur in a patient. The oxygen level measurements are used as feedback signals. These feedback signals are applied to automatically control the rate of fluid extraction to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.
摘要翻译： 公开了一种用于体外处理血液以从流体过载患者中去除流体的方法和系统，其非侵入性地测量静脉血中的氧水平。 氧气血液浓度用于检测患者中何时会发生低血压。 氧气测量值用作反馈信号。 这些反馈信号被应用于自动控制流体提取的速率以达到期望的临床结果，并避免在患者体内产生低血压危象。
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8.发明授权Method and apparatus for blood withdrawal and infusion using a pressure controller 有权使用压力控制器进行抽血和输液的方法和装置公开(公告)号：US07462161B2
公开(公告)日：2008-12-09
申请号：US11154569
申请日：2005-06-17
申请人： John O'Mahony , Mark Gelfand , Edward G. Rychlick
发明人： John O'Mahony , Mark Gelfand , Edward G. Rychlick
CPC分类号： A61M1/34 , A61M1/1692 , A61M1/341 , A61M1/3639 , A61M1/3656 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , B01D61/22
摘要： A method and apparatus for controlling blood withdrawal and infusion flow rate with the use of a pressure controller. The pressure controller uses pressure targets based upon occlusion limits that are calculated as a function of flow. The controller has the ability to switch from controlling withdrawal pressure to controlling infusion pressure based upon the detection of an occlusion. The controller distinguishes between partial and total occlusions of the withdrawal vein providing blood access. Depending on the nature of occlusion, the controller limits or temporarily reverses blood flow and, thus, prevents withdrawal vessel collapse or reverses blood flow to quickly infuse blood into the vessel without participation from operator.
摘要翻译： 一种使用压力控制器控制取血和输注流速的方法和装置。 压力控制器使用基于作为流量的函数计算的阻塞极限的压力目标。 控制器能够根据遮挡的检测从控制提取压力转换到控制输液压力。 控制器区分提供血液通道的撤离静脉的部分和全部闭塞。 根据闭塞的性质，控制器限制或暂时逆转血液流动，从而防止撤离血管塌陷或逆转血液，以便在没有操作者参与的情况下将血液快速注入血管。
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公开(公告)号：US20070123838A1
公开(公告)日：2007-05-31
申请号：US11620438
申请日：2007-01-05
申请人： Steven Bernard , John O'Mahony , Andrew Halpert , Mark Gelfand , Howard Levin
发明人： Steven Bernard , John O'Mahony , Andrew Halpert , Mark Gelfand , Howard Levin
IPC分类号： A61M31/00
CPC分类号： A61M1/34 , A61M1/341 , A61M1/342 , A61M1/3431 , A61M1/3441 , A61M1/3451 , A61M1/36 , A61M1/3613 , A61M1/3615 , A61M1/3621 , A61M2205/15 , A61M2205/3331 , B01D61/145 , B01D61/22
摘要： An extracorporeal blood circuit including: a withdrawal conduit connectable to a coronary withdrawal catheter; a withdrawal pump connectable to the withdrawal conduit, wherein a pumping rate of the withdrawal pump determines a blood withdrawal rate from the coronary withdrawal catheter; a filter having an input connected to the withdrawal conduit and a blood output connected to an infusion conduit and a filtrate output connected to a filtrate conduit; a filtrate measurement device to determine an amount of filtrate removed from the blood in the filter; a fluid supplementation conduit providing a blood replacement fluid to at least one of the withdrawal conduit, filter and infusion conduit; a supplementation pump connectable to the fluid supplementation conduit, wherein a pumping rate of the supplementation pump determines a rate at which the blood replacement fluid flows into the blood flowing through the blood circuit, and a controller regulating the pumping rate of the supplementation pump such that the rate of the blood replacement fluid provides an amount of blood replacement fluid to the at least one of the withdrawal conduit, filter and infusion conduit so as to substantially match the amount of filtrate removed.
摘要翻译： 一种体外血液回路，包括：可连接到冠状动脉取出导管的取出导管; 一个可连接到取出导管的抽吸泵，其中抽吸泵的泵送速率决定了冠状动脉取出导管的血液抽出速率; 过滤器，其具有连接到所述抽出管道的输入件，以及连接到输注管道的血液输出件和连接到滤液管道的滤液输出件; 滤液测量装置，用于确定从过滤器中的血液中除去的滤液量; 流体补充导管，其向至少一个取出导管，过滤器和输注导管提供血液置换流体; 补充泵可连接到流体补充导管，其中补充泵的泵送速率确定血液置换液体流入血液循环中的血液的速率，以及调节补充泵的泵送速率的控制器，使得 血液置换液体的速率向抽出管道，过滤器和输注管道中的至少一个提供一定量的血液置换液体，以便基本上匹配除去的滤液量。
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10.发明授权Method and apparatus for blood withdrawal and infusion using a pressure controller 有权使用压力控制器进行抽血和输液的方法和装置公开(公告)号：US08267881B2
公开(公告)日：2012-09-18
申请号：US12719667
申请日：2010-03-08
申请人： John O'Mahony , Mark Gelfand , Edward Rychlick
发明人： John O'Mahony , Mark Gelfand , Edward Rychlick
CPC分类号： A61M1/34 , A61M1/1692 , A61M1/341 , A61M1/3639 , A61M1/3656 , A61M2205/15 , A61M2205/18 , A61M2205/3331 , A61M2205/3334 , A61M2205/50 , A61M2205/502 , B01D61/22
摘要： A method and apparatus for controlling blood withdrawal and infusion flow rate with the use of a pressure controller. The pressure controller uses pressure targets based upon occlusion limits that are calculated as a function of flow. The controller has the ability to switch from controlling withdrawal pressure to controlling infusion pressure based upon the detection of an occlusion. The controller distinguishes between partial and total occlusions of the withdrawal vein providing blood access. Depending on the nature of occlusion, the controller limits or temporarily reverses blood flow and, thus, prevents withdrawal vessel collapse or reverses blood flow to quickly infuse blood into the vessel without participation from operator.
摘要翻译： 一种使用压力控制器控制取血和输注流速的方法和装置。 压力控制器使用基于作为流量的函数计算的阻塞极限的压力目标。 控制器能够根据遮挡的检测从控制提取压力转换到控制输液压力。 控制器区分提供血液通道的撤离静脉的部分和全部闭塞。 根据闭塞的性质，控制器限制或暂时逆转血液流动，从而防止撤离血管塌陷或逆转血液，以便在没有操作者参与的情况下将血液快速注入血管。
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