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1.发明申请公开(公告)号：US20080097273A1
公开(公告)日：2008-04-24
申请号：US11960145
申请日：2007-12-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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2.发明授权公开(公告)号：US07311689B2
公开(公告)日：2007-12-25
申请号：US10642638
申请日：2003-08-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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3.发明授权公开(公告)号：US07935071B2
公开(公告)日：2011-05-03
申请号：US11960145
申请日：2007-12-19
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A fluid removal apparatus comprising a blood removal catheter for insertion into a peripheral vein or artery and having a size 16 standard gage needle or less; a filter having a blood inlet port coupled to the blood removal catheter, a blood outlet port, an excess fluid removal port, and a blood flow passage with porous membrane which passes fluids to the fluid removal port and retains solutes of 60,000 Daltons or greater, and a blood return catheter for inserting into a peripheral vein or artery and having a size of 16 standard gage needle or less.
摘要翻译： 一种流体去除装置，包括用于插入到外周静脉或动脉中并具有尺寸16标准规格针或更小的止血导管; 过滤器，其具有联接到除血导管的血液入口端口，血液出口端口，多余的流体移除端口以及具有多孔膜的血流通道，其将流体传递到流体移除端口并保持60,000道尔顿或更大的溶质， 以及用于插入外周静脉或动脉并具有16个标准规格针或更小尺寸的血液回流导管。
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公开(公告)号：US08603021B2
公开(公告)日：2013-12-10
申请号：US13098853
申请日：2011-05-02
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US20110208106A1
公开(公告)日：2011-08-25
申请号：US13098853
申请日：2011-05-02
IPC分类号： A61M1/16
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： An ultrafiltration filter for an extracorporeal blood circuit having an input for blood withdrawn from a human patient and a blood output for filtered blood to be infused into the patient including: a filter body having a length of at least 20 centimeters (cm) and an interior diameter of no greater than 1.5 cm; an input at a first end of the body to receive the withdrawn blood; an output at a second end of the body to discharge the filtered blood; a filter membrane in the body defining a blood passage through the body, wherein the membrane has an active filter membrane surface area of no greater than 0.2 meters squared (m2) and the filter membrane blocks passage of blood molecules having a molecular weight cut of greater than 60,000 Daltons and a volume of the blood passage in the filter being less than two percent of a cardiac output of the patient, and an ultrafiltrate output to the body and open to a side of the filter surface area opposite to the blood passage.
摘要翻译： 一种用于体外血液回路的超滤过滤器，其具有从人类患者抽出的血液的输入和用于输入到患者中的过滤血液的血液输出，包括：具有至少20厘米（cm）的长度和内部 直径不大于1.5厘米; 在身体的第一端的输入以接收所抽取的血液; 在身体的第二端处输出以排出经过滤的血液; 身体中的过滤膜限定穿过身体的血液通道，其中膜具有不大于0.2平方米（m2）的活性过滤膜表面积，并且过滤膜阻止具有更大分子量切割的血液分子的通过 超过60,000道尔顿，并且过滤器中的血液通道的体积小于患者的心输出量的2％，并且超滤液输出到身体并且向与血液通道相对的过滤器表面区域的一侧开口。
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公开(公告)号：US06890315B1
公开(公告)日：2005-05-10
申请号：US09618759
申请日：2000-07-18
CPC分类号： A61M1/341 , A61M1/1692 , A61M1/34 , A61M1/361 , A61M1/3612 , A61M2205/3393 , A61M2205/50 , A61M2205/7563
摘要： A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.
摘要翻译： 一种通过以小于患者总心输出量的百分之二的速率从外周血管中除血的血液超滤操作的方法和装置，以每小时0.1升至1.0升的速率提取液体，同时保留细胞和 公开了血液中的蛋白质，并将浓缩血液返回到二次血管。 使用小规格针头取出血液并返回。 当泵从患者循环血液时，过滤器使用占空比或泵控制从血液中除去超滤液，并且透明容器收集去除的流体。
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公开(公告)号：USRE38869E1
公开(公告)日：2005-11-08
申请号：US10936827
申请日：2004-09-09
IPC分类号： A61M1/34
摘要： An extracorporeal blood circuit is disclosed for withdrawing, filtering and returning blood from peripheral blood vessels. The blood passage in the circuit extends through a withdrawal tube connected to a catheter in a peripheral vein, a filter, one or more pressure sensors and return tube also connected to a catheter in a peripheral vein (which may or may not be the same vein as used for the withdrawal tube). The blood passage is air free, and has smooth passage walls which promoted continuous and uniform flow of the blood through the circuit.
摘要翻译： 公开了用于从外周血管抽出，过滤和返回血液的体外血液回路。 电路中的血液通道延伸通过连接到外周静脉中的导管的抽出管，过滤器，一个或多个压力传感器和返回管，其也连接到外周静脉中的导管（其可以是或可以不是相同的静脉 如用于取出管）。 血液通道是无空气的，并且具有平滑的通道壁，促进血液连续流动通过电路。
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公开(公告)号：US06533747B1
公开(公告)日：2003-03-18
申请号：US09698132
申请日：2000-10-30
IPC分类号： A61M134
CPC分类号： A61M1/34 , A61M1/341 , A61M1/361 , A61M1/3612 , A61M1/3639 , A61M1/3653 , A61M1/3663 , A61M2205/12 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393
摘要： An extracorporeal blood circuit is disclosed for withdrawing, filtering and returning blood from peripheral blood vessels. The blood passage in the circuit extends through a withdrawal tube connected to a catheter in a peripheral vein, a filter, one or more pressure sensors and return tube also connected to a catheter in a peripheral vein (which may or may not be the same vein as used for the withdrawal tube). The blood passage is air free, and has smooth passage walls which promoted continuous and uniform flow of the blood through the circuit.
摘要翻译： 公开了用于从外周血管抽出，过滤和返回血液的体外血液回路。 电路中的血液通道延伸通过连接到外周静脉中的导管的抽出管，过滤器，一个或多个压力传感器和返回管，其也连接到外周静脉中的导管（其可以是或可以不是相同的静脉 如用于取出管）。 血液通道是无空气的，并且具有平滑的通道壁，促进血液连续流动通过电路。
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公开(公告)号：US09295773B2
公开(公告)日：2016-03-29
申请号：US13884115
申请日：2011-11-09
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M39/02 , A61M2039/0258 , A61M2039/027 , A61M2039/0285 , A61M2039/0288 , A61M2039/0291 , A61M2039/0294 , A61M2205/582 , A61M2207/00
摘要： A medical blood access system used for hemodialysis treatment to enable blood withdrawal for processing of blood by an external apparatus and return the same blood to a patient, comprising an interfacial fluid conduit between the machine and patient's blood supply which is repeatedly connectable along a guided pathway passing through epidermis and subcutaneous tissue via a naturally formed tissue tract to enter blood space, providing improved patient safely, convenience, effective prophylaxis, without bleeding or tissue trauma or pain, and is executable by the patient to precisely connect and disconnect with minimal disfigurement or life restrictions, and is useable on virtually all patients soon after placement and is robust and safe to high blood flow.
摘要翻译： 一种用于血液透析治疗的医用血液存取系统，用于通过外部设备进行血液处理以取出血液，并将相同的血液返回给患者，其包括在机器和患者的血液供应之间的界面流体导管，其可沿导向路径反复连接 通过表皮和皮下组织经由天然形成的组织管道进入血液空间，提供改善的患者安全，方便，有效的预防，没有出血或组织创伤或疼痛，并且可由患者执行以最小化的形态精确连接和断开， 寿命限制，并且几乎所有患者在放置后不久可以使用，并且对于高血流量是稳健和安全的。
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10.发明申请公开(公告)号：US20100145252A1
公开(公告)日：2010-06-10
申请号：US12460787
申请日：2009-07-24
CPC分类号： A61M25/0017 , A01N43/88 , A61K31/549 , A61K38/38 , A61K47/32 , A61L2/16 , A61L29/126 , A61M1/3661 , A61M2025/0056
摘要： Catheters used for medical treatment, e.g., hemodialysis are filled with a locking solution, usually heparin between treatments. To prevent infections, antimicrobial or antibiotic substances have been used as locking solution alone or in combination with antithrombotic substances. It has been found that these locking solutions are rapidly washed out from the catheter tip. The invention describes a thixotropic gel that can be used as locking solution. Beneficial substances, e.g., antimicrobial or antibiotic substances can be added to the gel. A preferred antimicrobial substance is taurolidin alone or in combination with salicylic acid or one of its salts.
摘要翻译： 用于医疗，例如血液透析的导管填充有锁定溶液，通常在治疗之间是肝素。 为了防止感染，抗微生物剂或抗生素物质已被用作单独的锁定溶液或与抗血栓形成物质组合使用。 已经发现这些锁定溶液从导管末端快速洗出。 本发明描述了可用作锁定溶液的触变凝胶。 可以将有益物质，例如抗微生物剂或抗生素物质加入到凝胶中。 优选的抗微生物物质是单独的taurolidin或与水杨酸或其盐之一组合。
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