公开(公告)号：US20100291584A1

公开(公告)日：2010-11-18

申请号：US12863526

申请日：2009-02-02

申请人： Hsian-Rong Tseng ,  Kenichiro Kamei ,  Jing Sun ,  Paul S. Mischel ,  Michael D. Masterman-Smith ,  David A. Nathanson ,  Tiffany Huang ,  Michael Van Dam ,  Christian Behrenbruch ,  Shawn M. Sarkaria

发明人： Hsian-Rong Tseng ,  Kenichiro Kamei ,  Jing Sun ,  Paul S. Mischel ,  Michael D. Masterman-Smith ,  David A. Nathanson ,  Tiffany Huang ,  Michael Van Dam ,  Christian Behrenbruch ,  Shawn M. Sarkaria

IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/50

CPC分类号： C12M23/16 ,  B01L3/021 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0816 ,  G01N15/1484 ,  G01N35/1065 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2035/00158 ,  G01N2035/1039

摘要： A microfluidic system has a pipette system comprising a plurality of pipettes, a microfluidic chip arranged proximate the pipette system, an imaging optical detection system arranged proximate the microfluidic chip, and an image processing system in communication with the imaging optical detection system. The microfluidic chip has a plurality of cell culture chambers defined by a body of the microfluidic chip, each cell culture chamber being in fluid connection with an input channel and an output channel defined by the microfluidic chip. The pipette system is constructed and arranged to at least one of inject fluid through the plurality of pipettes into the plurality of input channels or extract fluid through the plurality of pipettes from the plurality of output channels while the microfluidic system is in operation.

摘要翻译： 微流体系统具有包括多个移液管的移液管系统，靠近移液管系统布置的微流体芯片，布置在微流体芯片附近的成像光学检测系统以及与成像光学检测系统通信的图像处理系统。 微流体芯片具有由微流体芯片的主体限定的多个细胞培养室，每个细胞培养室与输入通道和由微流体芯片限定的输出通道流体连接。 移液管系统被构造并布置成通过多个移液管的注射流体中的至少一个进入多个输入通道，或者在微流体系统运行时从多个输出通道提取流体通过多个移液管。

公开(公告)号：US09688673B2

公开(公告)日：2017-06-27

申请号：US14002964

申请日：2012-03-08

申请人： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

发明人： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  G01N33/50

CPC分类号： C07D417/12 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  C07D417/14 ,  G01N33/5088

摘要： The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.

公开(公告)号：US20130336883A1

公开(公告)日：2013-12-19

申请号：US14002964

申请日：2012-03-08

申请人： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

发明人： Caius G. Radu ,  Hsiang-I Liao ,  Nagichettiar Satyamurthy ,  Johannes Czernin ,  Jennifer M. Murphy ,  David A. Nathanson

IPC分类号： C07D417/12 ,  C07D417/14 ,  G01N33/50

CPC分类号： C07D417/12 ,  A61K31/426 ,  A61K31/44 ,  A61K31/506 ,  A61K31/513 ,  C07D417/14 ,  G01N33/5088

摘要： The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.

摘要翻译： 本发明提供了结合脱氧胞苷激酶（dCK）的化合物和包含含有该化合物的药学上可接受的组合物的组合物。 所述化合物可用于治疗涉及dCK活性的疾病和病症，例如癌症和免疫疾病。 该化合物还用于包括正电子发射断层扫描（PET）成像在内的临床方法。