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公开(公告)号：US08709467B2
公开(公告)日：2014-04-29
申请号：US13380520
申请日：2009-06-26
Applicant: Erik Pierstorff , Edward Chow , Dean Ho , Christian Behrenbruch
Inventor： Erik Pierstorff , Edward Chow , Dean Ho , Christian Behrenbruch
IPC: A61F2/00
CPC classification number: A61K47/32 , A61K9/0024 , A61K9/2086 , A61K9/7007 , A61L15/24 , A61L15/26 , A61L15/425 , A61L15/44 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , A61L2300/608 , C08L53/02 , C08L65/04
Abstract: This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an exemplary embodiment comprised of a microfilm base (12), a reservoir of a therapeutic (14) disposed about the microfilm base (12) and a top layer (24) that is (i) a plurality of laminated layers (24) of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.
Abstract translation: 本发明在用于治疗性递送的受控洗脱装置领域。 存在对用于治疗剂的局部和延长递送的独立能力的装置的需要。 本发明克服了这个需求，本发明具有由微缩胶片基底（12），围绕微缩胶片基底（12）设置的治疗剂（14）的储存器和顶层（24）组成的示例性实施方案，所述顶层是（i） 多聚苯乙烯聚合物的层压层（24）和/或（ii）赋予氧化官能化的对位单元的对 - 木聚烯聚合物。 该装置的厚度最好在约10至约200微米的范围内。 该装置可用于介入和预防性药物的广谱治疗剂的局部释放。
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Patent Agency Ranking
公开(公告)号：US20100291584A1
公开(公告)日：2010-11-18
申请号：US12863526
申请日：2009-02-02
Applicant: Hsian-Rong Tseng , Kenichiro Kamei , Jing Sun , Paul S. Mischel , Michael D. Masterman-Smith , David A. Nathanson , Tiffany Huang , Michael Van Dam , Christian Behrenbruch , Shawn M. Sarkaria
Inventor： Hsian-Rong Tseng , Kenichiro Kamei , Jing Sun , Paul S. Mischel , Michael D. Masterman-Smith , David A. Nathanson , Tiffany Huang , Michael Van Dam , Christian Behrenbruch , Shawn M. Sarkaria
CPC classification number: C12M23/16 , B01L3/021 , B01L3/502715 , B01L2200/027 , B01L2300/0816 , G01N15/1484 , G01N35/1065 , G01N2015/1006 , G01N2015/1477 , G01N2035/00158 , G01N2035/1039
Abstract: A microfluidic system has a pipette system comprising a plurality of pipettes, a microfluidic chip arranged proximate the pipette system, an imaging optical detection system arranged proximate the microfluidic chip, and an image processing system in communication with the imaging optical detection system. The microfluidic chip has a plurality of cell culture chambers defined by a body of the microfluidic chip, each cell culture chamber being in fluid connection with an input channel and an output channel defined by the microfluidic chip. The pipette system is constructed and arranged to at least one of inject fluid through the plurality of pipettes into the plurality of input channels or extract fluid through the plurality of pipettes from the plurality of output channels while the microfluidic system is in operation.
Abstract translation: 微流体系统具有包括多个移液管的移液管系统，靠近移液管系统布置的微流体芯片，布置在微流体芯片附近的成像光学检测系统以及与成像光学检测系统通信的图像处理系统。 微流体芯片具有由微流体芯片的主体限定的多个细胞培养室，每个细胞培养室与输入通道和由微流体芯片限定的输出通道流体连接。 移液管系统被构造并布置成通过多个移液管的注射流体中的至少一个进入多个输入通道，或者在微流体系统运行时从多个输出通道提取流体通过多个移液管。
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公开(公告)号：US08974232B2
公开(公告)日：2015-03-10
申请号：US12920819
申请日：2009-03-03
Applicant: Christian Behrenbruch , William Kaiser , Majid Sarrafzadeh , Maxim Batalin
Inventor： Christian Behrenbruch , William Kaiser , Majid Sarrafzadeh , Maxim Batalin
CPC classification number: A45B3/00 , G06F19/00 , G06F19/3481
Abstract: A computer readable storage medium includes executable instructions to receive sensor data measurements associated with usage of a mobility aid device and extract sensor feature parameters from the sensor data measurements. The computer readable storage medium further includes executable instructions to derive a usage state corresponding to the usage of the mobility aid device, based on the sensor feature parameters.
Abstract translation: 计算机可读存储介质包括用于接收与移动性辅助设备的使用相关联的传感器数据测量的可执行指令，并从传感器数据测量中提取传感器特征参数。 计算机可读存储介质还包括基于传感器特征参数导出与移动性辅助设备的使用相对应的使用状态的可执行指令。
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公开(公告)号：US20120135061A1
公开(公告)日：2012-05-31
申请号：US13380520
申请日：2009-06-26
Applicant: Erik Pierstorff , Edward Chow , Dean Ho , Christian Behrenbruch
Inventor： Erik Pierstorff , Edward Chow , Dean Ho , Christian Behrenbruch
IPC: A61K9/00
CPC classification number: A61K47/32 , A61K9/0024 , A61K9/2086 , A61K9/7007 , A61L15/24 , A61L15/26 , A61L15/425 , A61L15/44 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/602 , A61L2300/608 , C08L53/02 , C08L65/04
Abstract: This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an exemplary embodiment comprised of a microfilm base (12), a reservoir of a therapeutic (14) disposed about the microfilm base (12) and a top layer (24) that is (i) a plurality of laminated layers (24) of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.
Abstract translation: 本发明在用于治疗性递送的受控洗脱装置领域。 存在对用于治疗剂的局部和延长递送的独立能力的装置的需要。 本发明克服了这个需求，本发明具有由微缩胶片基底（12），围绕微缩胶片基底（12）设置的治疗剂（14）的储存器和顶层（24）组成的示例性实施方案，所述顶层是（i） 多聚苯乙烯聚合物的层压层（24）和/或（ii）赋予氧化官能化的对位单元的对 - 木聚烯聚合物。 该装置的厚度最好在约10至约200微米的范围内。 该装置可用于介入和预防性药物的广谱治疗剂的局部释放。
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公开(公告)号：US20050238253A1
公开(公告)日：2005-10-27
申请号：US10502034
申请日：2003-09-18
Applicant: Christian Behrenbruch , Jerome Marie Declerck
Inventor： Christian Behrenbruch , Jerome Marie Declerck
CPC classification number: G06T3/0081 , G06T7/33
Abstract: A method of displaying two images in registration with each other in which a visually distinguishable overlay is also displayed to represent the degree of “confidence” in the registration process. The degree of confidence may be calculated on the basis of the degree of non-rigid deformation needed to register the two images. The visually distinguishable overlay can be in the form of a transparent color wash whose color and/or intensity indicate the level of confidence, or a symbol, e.g. a circle, whose size represents the degree of confidence.
Abstract translation: 显示彼此对准的两个图像的方法，其中还显示视觉上可区分的覆盖以表示注册过程中的“置信度”。 可以基于注册两个图像所需的非刚性变形的程度来计算置信度。 视觉上可区分的覆盖物可以是其颜色和/或强度指示置信水平的透明颜色洗涤物的形式，或者例如符号。 一个圆圈，其大小代表了信心的程度。
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公开(公告)号：US20110061697A1
公开(公告)日：2011-03-17
申请号：US12920819
申请日：2009-03-03
Applicant: Christian Behrenbruch , William Kaiser , Majid Sarrafzadeh , Maxim Batalin
Inventor： Christian Behrenbruch , William Kaiser , Majid Sarrafzadeh , Maxim Batalin
CPC classification number: A45B3/00 , G06F19/00 , G06F19/3481
Abstract: A computer readable storage medium includes executable instructions to receive sensor data measurements associated with usage of a mobility aid device and extract sensor feature parameters from the sensor data measurements. The computer readable storage medium further includes executable instructions to derive a usage state corresponding to the usage of the mobility aid device, based on the sensor feature parameters.
Abstract translation: 计算机可读存储介质包括用于接收与移动性辅助设备的使用相关联的传感器数据测量的可执行指令，并从传感器数据测量中提取传感器特征参数。 计算机可读存储介质还包括基于传感器特征参数导出与移动性辅助设备的使用相对应的使用状态的可执行指令。
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