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    Heat dissipation assembly with resilient fastener
    1.
    发明授权
    Heat dissipation assembly with resilient fastener 失效
    具有弹性紧固件的散热组件

    公开(公告)号：US06948554B2

    公开(公告)日：2005-09-27

    申请号：US10737596

    申请日：2003-12-15

    申请人： Hsieh Kun Lee ,  Dongyun Lee ,  Zhijie Zhang ,  Fei Huang

    发明人： Hsieh Kun Lee ,  Dongyun Lee ,  Zhijie Zhang ,  Fei Huang

    IPC分类号： H01L23/40 ,  F28F7/00 ,  H01L23/12

    CPC分类号： H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A heat dissipation assembly includes a heat sink (20), a backplate (50), a pair of posts (60) and a fastener (10). The heat sink is attached on a CPU (30) which is mounted on a PCB (40). The backplate is disposed below the PCB. The fastener includes a main body (14) spanning on the heat sink, a resilient member (16) and an operating member (12). The posts extends through the backplate and engaged with the main body. Before the fastener is activated, the resilient member and the operating member squeezes the main body therebetween. When the fastener is activated, the operating member is above the main body. The resilient member resiliently presses the heat sink toward the CPU and the main body with opposite directional forces. The posts are consequently forced by the main body to urge the backplate against the PCB.

    摘要翻译： 散热组件包括散热器（20），背板（50），一对柱（60）和紧固件（10）。 散热器安装在安装在PCB（40）上的CPU（30）上。 背板设置在PCB的下方。 紧固件包括跨越散热器的主体（14），弹性构件（16）和操作构件（12）。 柱延伸穿过背板并与主体接合。 在紧固件被激活之前，弹性构件和操作构件在其间挤压主体。 当紧固件被激活时，操作构件在主体上方。 弹性构件以相反的方向向CPU和主体弹性地按压散热器。 因此，柱子被主体强制推动背板抵靠PCB。

    Heat dissipation assembly with resilient fastener
    2.
    发明申请
    Heat dissipation assembly with resilient fastener 失效
    具有弹性紧固件的散热组件

    公开(公告)号：US20050126753A1

    公开(公告)日：2005-06-16

    申请号：US10737596

    申请日：2003-12-15

    申请人： Hsieh Lee ,  Dongyun Lee ,  Zhijie Zhang ,  Fei Huang

    发明人： Hsieh Lee ,  Dongyun Lee ,  Zhijie Zhang ,  Fei Huang

    IPC分类号： H01L23/40 ,  F28F7/00

    CPC分类号： H01L23/4093 ,  H01L2924/0002 ,  H01L2924/00

    摘要： A heat dissipation assembly includes a heat sink (20), a backplate (50), a pair of posts (60) and a fastener (10). The heat sink is attached on a CPU (30) which is mounted on a PCB (40). The backplate is disposed below the PCB. The fastener includes a main body (14) spanning on the heat sink, a resilient member (16) and an operating member (12). The posts extends through the backplate and engaged with the main body. Before the fastener is activated, the resilient member and the operating member squeezes the main body therebetween. When the fastener is activated, the operating member is above the main body. The resilient member resiliently presses the heat sink toward the CPU and the main body with opposite directional forces. The posts are consequently forced by the main body to urge the backplate against the PCB.

    摘要翻译： 散热组件包括散热器（20），背板（50），一对柱（60）和紧固件（10）。 散热器安装在安装在PCB（40）上的CPU（30）上。 背板设置在PCB的下方。 紧固件包括跨越散热器的主体（14），弹性构件（16）和操作构件（12）。 柱延伸穿过背板并与主体接合。 在紧固件被激活之前，弹性构件和操作构件在其间挤压主体。 当紧固件被激活时，操作构件在主体上方。 弹性构件以相反的方向向CPU和主体弹性地按压散热器。 因此，柱子被主体强制推动背板抵靠PCB。

    Article of Footwear with an Internal and External Midsole Structure
    5.
    发明申请
    Article of Footwear with an Internal and External Midsole Structure 有权
    具有内部和外部中底结构的鞋类物品

    公开(公告)号：US20130125421A1

    公开(公告)日：2013-05-23

    申请号：US13304151

    申请日：2011-11-23

    申请人： Barbara Stegmaier ,  Daniel A. Williamson ,  David J. Dirsa ,  Miaochang Zadnik ,  Fei Huang ,  Pu He

    发明人： Barbara Stegmaier ,  Daniel A. Williamson ,  David J. Dirsa ,  Miaochang Zadnik ,  Fei Huang ,  Pu He

    IPC分类号： A43B3/00 ,  A43D11/00 ,  A43D5/00 ,  A43B1/10

    CPC分类号： A43B1/10 ,  A43B1/0018 ,  A43B7/144 ,  A43B7/32 ,  A43B13/026 ,  A43B13/141 ,  A43B13/146 ,  A43B13/148 ,  A43B13/185 ,  A43B13/187 ,  B29D35/122

    摘要： Articles of footwear having both interior and exterior midsole components may include: (a) an upper that at least in part defines an interior chamber; (b) an interior midsole component within the interior chamber, wherein, at a forefoot region, the interior midsole component includes a longitudinal flexion line and a plurality of transverse flexion lines; and (c) an exterior sole structure engaged with the upper. This exterior sole structure may include: (a) an exterior midsole component in a heel region of the article of footwear that does not extend under the forefoot region of the article of footwear and (b) an outsole component that extends under the forefoot region. If desired, the outsole component may extend under the exterior midsole component in the rearfoot region. The interior midsole component may include a plurality of pod elements separated from one another by the flexion lines.

    摘要翻译： 具有内部和外部中底部件的鞋类物品可以包括：（a）至少部分地限定内部室的鞋面; （b）所述内部室内的内部中底部件，其中，在前脚区域，所述内部中底部件包括纵向弯曲线和多个横向弯曲线; 和（c）与上部接合的外部鞋底结构。 这种外部鞋底结构可以包括：（a）在鞋类物品的脚跟区域内的脚跟区域中的外部中底部件，其不延伸在鞋类物品的前脚区域的下方，以及（b）在鞋前部区域下延伸的外底部件。 如果需要，外底部件可以在后脚部区域的外部中底部分下方延伸。 内部中底部件可以包括通过弯曲线彼此分离的多个荚形部件。

    METHODS FOR TREATING CANCER IN PATIENTS HAVING IGF-1R INHIBITOR RESISTANCE
    6.
    发明申请
    METHODS FOR TREATING CANCER IN PATIENTS HAVING IGF-1R INHIBITOR RESISTANCE 审中-公开
    用于治疗IGF-1R抑制剂耐药性患者的方法

    公开(公告)号：US20120220594A1

    公开(公告)日：2012-08-30

    申请号：US13504498

    申请日：2010-10-29

    申请人： Fei Huang ,  Joan Carboni

    发明人： Fei Huang ,  Joan Carboni

    IPC分类号： A61K31/53 ,  A61P35/00 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

    摘要： A method for treating cancer comprising identifying a mammal that overexpresses breast cancer resistance protein; and administering to said mammal a pharmaceutical composition comprising a therapeutically effective amount of ixabepilone. In one aspect, the mammal is not administered an agent that is susceptible to breast cancer resistance protein overexpression resistance. In another aspect, the cancer is a solid tumor.

    摘要翻译： 一种治疗癌症的方法，包括鉴定过表达乳腺癌抗性蛋白质的哺乳动物; 以及向所述哺乳动物施用包含治疗有效量的阿沙比隆的药物组合物。 在一个方面，哺乳动物不施用易受乳腺癌抗性蛋白过表达抗性的药剂。 另一方面，癌症是实体肿瘤。

    Cascading security architecture
    7.
    发明申请
    Cascading security architecture 有权
    级联安全架构

    公开(公告)号：US20060253445A1

    公开(公告)日：2006-11-09

    申请号：US11413754

    申请日：2006-04-27

    申请人： Fei Huang ,  Shu Huang ,  Liwei Ren

    发明人： Fei Huang ,  Shu Huang ,  Liwei Ren

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30011 ,  G06F21/554

    摘要： A system and a method are disclosed for sensitive document management. The system includes one or more agents, a behavior analysis engine, a local policy engine, and a local matching service. The method identifies whether a document is sensitive, identifies behaviors applied to the document, determines whether the document contains sensitive information and determines whether to allow the identified behavior to continue based on security policies.

    摘要翻译： 公开了一种用于敏感文件管理的系统和方法。 系统包括一个或多个代理，行为分析引擎，本地策略引擎和本地匹配服务。 该方法识别文档是否敏感，识别应用于文档的行为，确定文档是否包含敏感信息，并确定是否允许基于安全策略继续识别的行为。

    Identification of polynucleotides and polypetide for predicting activity of compounds that interact with protein tyrosine kinase and or protein tyrosine kinase pathways
    8.
    发明申请
    Identification of polynucleotides and polypetide for predicting activity of compounds that interact with protein tyrosine kinase and or protein tyrosine kinase pathways 审中-公开
    鉴定用于预测与蛋白酪氨酸激酶和/或蛋白酪氨酸激酶途径相互作用的化合物的活性的多核苷酸和多肽

    公开(公告)号：US20060046249A1

    公开(公告)日：2006-03-02

    申请号：US10501035

    申请日：2003-01-17

    申请人： Fei Huang ,  Craig Fairchild ,  Francis Lee ,  Peter Shaw

    发明人： Fei Huang ,  Craig Fairchild ,  Francis Lee ,  Peter Shaw

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： G01N33/5011 ,  C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/5023 ,  G01N2333/91215 ,  G01N2800/52 ,  G16B20/00

    摘要： The present invention describes polynucleotides and polypeptides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., colon cell lines, to treatment with compounds that interact with and inhibit src tyrosine kinases. These polynucleotides and polypeptides have been shown, through a weighted voting cross validation program, to have utility in predicting the intrinsic resistance and sensitivity of colon cell lines to these compounds. Such polynucleotides and polypeptides whose expression levels correlate highly with drug sensitivity or resistance comprise predictor or marker sets of polynucleotides and polypeptides that are useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas in which signaling through src tyrosine kinase of the src tyrosine kinase pathway is involved with the disease process.

    摘要翻译： 本发明描述了已被发现与将细胞例如结肠细胞系相对固有的敏感性或抗性与与酪氨酸激酶相互作用并抑制酪氨酸激酶的化合物进行治疗相关的多核苷酸和多肽。 已经通过加权投票交叉验证程序显示了这些多核苷酸和多肽在预测结肠细胞系对这些化合物的固有抗性和敏感性方面具有实用性。 其表达水平与药物敏感性或抗性高度相关的这样的多核苷酸和多肽包括可用于预测药物反应的方法中的多核苷酸和多肽的预测物或标志物组，以及作为疾病管理中的预后或诊断指标，特别是在其中 通过src酪氨酸激酶信号传导src酪氨酸激酶途径参与疾病过程。

    Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in lung cancer cells
    9.
    发明申请
    Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in lung cancer cells 审中-公开
    鉴定用于预测与肺癌细胞相互作用和/或调节蛋白酪氨酸激酶和/或蛋白酪氨酸激酶途径的化合物的活性的多核苷酸

    公开(公告)号：US20060019284A1

    公开(公告)日：2006-01-26

    申请号：US11169041

    申请日：2005-06-28

    申请人： Fei Huang ,  Karen Reeves ,  Xia Han ,  Craig Fairchild ,  Peter Shaw

    发明人： Fei Huang ,  Karen Reeves ,  Xia Han ,  Craig Fairchild ,  Peter Shaw

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The present invention describes polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., lung cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Ephr. These polynucleotides have been shown, through a weighted voting cross validation program, to have utility in predicting the resistance and sensitivity of lung cell lines to the compounds. The expression level of some polynucleotides is regulated by treatment with a particular protein tyrosine kinase inhibitor compound, thus indicating that these polynucleotides are involved in the protein tyrosine kinase signal transduction pathway, e.g., Src tyrosine kinase. Such polynucleotides, whose expression levels correlate highly with drug sensitivity or resistance and which are modulated by treatment with the compounds, comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., lung cancer, in which signaling through the protein tyrosine kinase pathway, such as the Src tyrosine kinase pathway, is involved with the disease process.

    摘要翻译： 本发明描述了已经发现与将细胞（例如肺细胞系）的相对固有敏感性或抗性相关联的化合物与与蛋白酪氨酸激酶相互作用并调节，例如抑制蛋白质酪氨酸激酶（例如， ，Src家族酪氨酸激酶的成员，例如Src，Fgr，Fyn，是，Blk，Hck，Lck和Lyn，以及其它蛋白酪氨酸激酶，包括Bcr-abl，Jak，PDGFR，c-kit和 以弗所 已经通过加权投票交叉验证程序显示了这些多核苷酸可用于预测肺细胞系对化合物的抵抗力和敏感性。 一些多核苷酸的表达水平通过用特定蛋白酪氨酸激酶抑制剂化合物的治疗来调节，因此表明这些多核苷酸参与蛋白酪氨酸激酶信号转导途径，例如Src酪氨酸激酶。 这些多核苷酸的表达水平与药物敏感性或抗性高度相关并且通过用化合物处理而被调节的多核苷酸包括用于预测药物反应的方法中的多核苷酸预测物或标志物组，以及疾病管理中的预后或诊断指标，特别是在那些 疾病领域，例如肺癌，其中通过蛋白酪氨酸激酶途径的信号，例如Src酪氨酸激酶途径参与疾病过程。