公开(公告)号：US08217670B2

公开(公告)日：2012-07-10

申请号：US12500689

申请日：2009-07-10

申请人： Hsin-Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

发明人： Hsin-Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

IPC分类号： G01R27/08

CPC分类号： G01N33/5438 ,  G01N27/4145

摘要： The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and being in contact with the first electrode and the second electrode. The semiconductor layer has a plurality of probe groups bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance having bonding specificity with the probe groups. The semiconductor layer is bonded with the probe groups, and the detection of detected object is performed in an instant, quick, rapid, and sensitive manner by measuring variation in electric current, avoiding the use of fluorescent reading equipment for reading fluorescent signals.

摘要翻译： 本发明提供了一种无标签传感器，其包括基板，形成在基板上的第一电极，形成在基板上并与第一电极间隔开的第二电极，以及形成在基板上并与基板接触的半导体层 第一电极和第二电极。 半导体层具有多个通过官能化键合到半导体层的探针组，用于感测与探针组具有键合特异性的偶联特异性物质。 半导体层与探针组结合，通过测量电流的变化，以瞬时，快速，快速和敏感的方式进行检测对象的检测，避免使用荧光读取设备读取荧光信号。

公开(公告)号：US20100237885A1

公开(公告)日：2010-09-23

申请号：US12500689

申请日：2009-07-10

申请人： Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

发明人： Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

IPC分类号： G01R19/00 ,  H01L29/12 ,  H01L51/30

CPC分类号： G01N33/5438 ,  G01N27/4145

摘要： A label-free sensor is disclosed. The label-free sensor comprises a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and is in contact with the first electrode and the second electrode, wherein the semiconductor layer has a plurality of probe groups, which are bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance, which has bonding specificity with the probe groups. The semiconductor layer of the label-free sensor of the present invention is bonded with probe groups, and the detection of detected object is performed in instant, quick, rapid, and sensitive manner by measuring variation in electric current, thereby avoiding the use of the fluorescent reading equipment for reading fluorescent signals.

摘要翻译： 公开了一种无标签传感器。 无标记传感器包括基板，形成在基板上的第一电极，形成在基板上并与第一电极隔开的第二电极，以及形成在基板上并与第一电极和第二电极接触的半导体层 第二电极，其中半导体层具有多个探针组，其通过官能化键合到半导体层，用于感测与探针组具有键合特异性的偶联特异性物质。 本发明的无标签传感器的半导体层与探针组接合，通过测量电流的变化，以即时，快速，快速，敏感的方式进行检测对象的检测，从而避免使用 用于读取荧光信号的荧光阅读设备。