公开(公告)号：US08217670B2

公开(公告)日：2012-07-10

申请号：US12500689

申请日：2009-07-10

Applicant: Hsin-Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

Inventor： Hsin-Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

IPC: G01R27/08

CPC classification number: G01N33/5438 ,  G01N27/4145

Abstract: The invention provides a label-free sensor that includes a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and being in contact with the first electrode and the second electrode. The semiconductor layer has a plurality of probe groups bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance having bonding specificity with the probe groups. The semiconductor layer is bonded with the probe groups, and the detection of detected object is performed in an instant, quick, rapid, and sensitive manner by measuring variation in electric current, avoiding the use of fluorescent reading equipment for reading fluorescent signals.

Abstract translation: 本发明提供了一种无标签传感器，其包括基板，形成在基板上的第一电极，形成在基板上并与第一电极间隔开的第二电极，以及形成在基板上并与基板接触的半导体层 第一电极和第二电极。 半导体层具有多个通过官能化键合到半导体层的探针组，用于感测与探针组具有键合特异性的偶联特异性物质。 半导体层与探针组结合，通过测量电流的变化，以瞬时，快速，快速和敏感的方式进行检测对象的检测，避免使用荧光读取设备读取荧光信号。

公开(公告)号：US07968875B2

公开(公告)日：2011-06-28

申请号：US12500830

申请日：2009-07-10

Applicant: Hsin-Fei Meng ,  Sheng-Fu Hong ,  Hsin-Rong Tseng ,  En-Chen Chen ,  Chia-Hung Chu

Inventor： Hsin-Fei Meng ,  Sheng-Fu Hong ,  Hsin-Rong Tseng ,  En-Chen Chen ,  Chia-Hung Chu

IPC: H01L51/42

CPC classification number: H01L51/4246 ,  B82Y10/00 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0047 ,  H01L51/4253 ,  Y02E10/549

Abstract: An organic photosensitive optoelectronic device includes an anode, an organic photosensitive layer formed on the anode and having a donor portion and an acceptor portion, a hole blocking layer formed on the organic photosensitive layer so as for the organic photosensitive layer to be sandwiched between the anode and the hole blocking layer, and a cathode formed on the hole blocking layer so as for the hole blocking layer to be sandwiched between the cathode and the organic photosensitive layer. The highest occupied molecular orbitals (HOMO) of the hole blocking layer is at least 0.3 eV higher than that of the donor portion. Therefore, the optoelectronic device efficiently suppresses dark current so as to enhance sensitivity when applied to a detector.

Abstract translation: 有机光敏光电子器件包括阳极，形成在阳极上的有机感光层，具有供体部分和受体部分，形成在有机感光层上的空穴阻挡层，以使有机感光层夹在阳极之间 和空穴阻挡层，以及形成在空穴阻挡层上以使空穴阻挡层夹在阴极和有机感光层之间的阴极。 空穴阻挡层的最高占据分子轨道（HOMO）比施主部分高至少0.3eV。 因此，光电子器件有效地抑制暗电流，以便在施加到检测器时提高灵敏度。

公开(公告)号：US20100291703A1

公开(公告)日：2010-11-18

申请号：US12775924

申请日：2010-05-07

Applicant: Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Yun-Ru Horng ,  Pei-Yu Tsai ,  Chia-Ming Yang

Inventor： Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Yun-Ru Horng ,  Pei-Yu Tsai ,  Chia-Ming Yang

IPC: G01N21/76 ,  G01J1/58 ,  G01N30/00

CPC classification number: G01N21/645 ,  G01N2021/7786 ,  G01N2201/062

Abstract: A biosensor applicable to an environment suitable for biosensing is provided, which is a solid-state element for performing detections in an aqueous environment. The biosensor at least includes a biosensing layer, a light-emitting diode and a photodiode. The biosensing layer causes changes in the light-emitting property thereof after absorbing, adsorbing and/or bonding with a biological substance released during in vivo signal transduction in an organism, and the rays of light generated by excitation of the light-emitting diode causes the biosensing layer to emit fluorescence. After the fluorescence is absorbed by the photodiode, it can be converted into an interpretable photocurrent signal. Afterwards, the meaning of the in vivo signal transduction can be understood by interpretation of the photocurrent signal.

Abstract translation: 提供适用于适合于生物传感的环境的生物传感器，其是用于在水性环境中进行检测的固态元件。 生物传感器至少包括生物传感层，发光二极管和光电二极管。 生物传感层在生物体内的体内信号转导中释放的生物物质吸收，吸附和/或粘合后引起其发光特性的变化，并且通过发光二极管的激发产生的光线导致 生物传感层发射荧光。 荧光被光电二极管吸收后，可将其转换为可解释的光电流信号。 之后，通过解释光电流信号可以了解体内信号转导的意义。

公开(公告)号：US20100237885A1

公开(公告)日：2010-09-23

申请号：US12500689

申请日：2009-07-10

Applicant: Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

Inventor： Hsin- Fei Meng ,  Sheng-Fu Hong ,  Yu-Chiang Chao ,  Chien-Cheng Liu ,  Wen-Hsing Liu ,  Cheng-Chung Chang ,  Jan-Hao Li ,  Ming-Zhi Dai

IPC: G01R19/00 ,  H01L29/12 ,  H01L51/30

CPC classification number: G01N33/5438 ,  G01N27/4145

Abstract: A label-free sensor is disclosed. The label-free sensor comprises a substrate, a first electrode formed on the substrate, a second electrode formed on the substrate and spaced away from the first electrode, and a semiconductor layer formed on the substrate and is in contact with the first electrode and the second electrode, wherein the semiconductor layer has a plurality of probe groups, which are bonded to the semiconductor layer by functionalization, for sensing a coupling-specific substance, which has bonding specificity with the probe groups. The semiconductor layer of the label-free sensor of the present invention is bonded with probe groups, and the detection of detected object is performed in instant, quick, rapid, and sensitive manner by measuring variation in electric current, thereby avoiding the use of the fluorescent reading equipment for reading fluorescent signals.

Abstract translation: 公开了一种无标签传感器。 无标记传感器包括基板，形成在基板上的第一电极，形成在基板上并与第一电极隔开的第二电极，以及形成在基板上并与第一电极和第二电极接触的半导体层 第二电极，其中半导体层具有多个探针组，其通过官能化键合到半导体层，用于感测与探针组具有键合特异性的偶联特异性物质。 本发明的无标签传感器的半导体层与探针组接合，通过测量电流的变化，以即时，快速，快速，敏感的方式进行检测对象的检测，从而避免使用 用于读取荧光信号的荧光阅读设备。

公开(公告)号：US20100283039A1

公开(公告)日：2010-11-11

申请号：US12500830

申请日：2009-07-10

Applicant: Hsin- Fei Meng ,  Sheng-Fu Hong ,  Hsin-Rong Tseng ,  En-Chen Chen ,  Chia-Hung Chu

Inventor： Hsin- Fei Meng ,  Sheng-Fu Hong ,  Hsin-Rong Tseng ,  En-Chen Chen ,  Chia-Hung Chu

IPC: H01L51/42

CPC classification number: H01L51/4246 ,  B82Y10/00 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0047 ,  H01L51/4253 ,  Y02E10/549

Abstract: An organic photosensitive optoelectronic device includes an anode, an organic photosensitive layer formed on the anode and having a donor portion and an acceptor portion, a hole blocking layer formed on the organic photosensitive layer so as for the organic photosensitive layer to be sandwiched between the anode and the hole blocking layer, and a cathode formed on the hole blocking layer so as for the hole blocking layer to be sandwiched between the cathode and the organic photosensitive layer. The highest occupied molecular orbitals (HOMO) of the hole blocking layer is at least 0.3 eV higher than that of the donor portion. Therefore, the optoelectronic device efficiently suppresses dark current so as to enhance sensitivity when applied to a detector.

Abstract translation: 有机光敏光电子器件包括阳极，形成在阳极上的有机感光层，具有供体部分和受体部分，形成在有机感光层上的空穴阻挡层，以使有机感光层夹在阳极之间 和空穴阻挡层，以及形成在空穴阻挡层上以使空穴阻挡层夹在阴极和有机感光层之间的阴极。 空穴阻挡层的最高占据分子轨道（HOMO）比施主部分高至少0.3eV。 因此，光电子器件有效地抑制暗电流，以便在施加到检测器时提高灵敏度。