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公开(公告)号：US20060073209A1
公开(公告)日：2006-04-06
申请号：US10958864
申请日：2004-10-05
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
IPC分类号： A61K31/704 , A61K31/7008 , A61K33/24 , A61K9/50
CPC分类号： A61K9/5153 , A61K31/7008 , A61K31/704 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of γ-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
摘要翻译： 本发明公开了由与半乳糖结合的γ-PGA-PLA嵌段共聚物作为用于治疗肝癌的潜在药物递送系统的纳米颗粒。
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公开(公告)号：US07348026B2
公开(公告)日：2008-03-25
申请号：US10958864
申请日：2004-10-05
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Ting-Fan Yang , Chin-Tsung Huang , Hosheng Tu
CPC分类号： A61K9/5153 , A61K31/7008 , A61K31/704 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of γ-PGA-PLA block copolymers conjugated with galactosamine as a potential drug delivery system for treating liver cancers.
摘要翻译： 本发明公开了由与半乳糖结合的γ-PGA-PLA嵌段共聚物作为用于治疗肝癌的潜在药物递送系统的纳米颗粒。
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公开(公告)号：US20060034885A1
公开(公告)日：2006-02-16
申请号：US10929047
申请日：2004-08-27
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Chin-Tsung Huang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Chin-Tsung Huang , Hosheng Tu
IPC分类号： A61F13/00
CPC分类号： A61L31/10 , A61F2/92 , A61F2210/0004 , A61F2230/0054 , A61F2230/0091 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： The present invention relates to a drug-loaded biodegradable stent and methods for treating vulnerable plaques of a patient comprising a plurality of layers or zones, each layer or zone comprising its own specific biodegradation rate and its specific drug loading characteristics. In one embodiment, the layers and zones are configured and arranged, in combination, radially, circumferentially and longitudinally.
摘要翻译： 本发明涉及装载药物的可生物降解支架以及用于治疗包括多层或多个区域的患者脆弱斑块的方法，每个层或区域包含其自身特定的生物降解速率及其特定的药物负载特性。 在一个实施例中，层和区域被组合和组合地径向地，周向地和纵向地布置。
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公开(公告)号：US07871990B1
公开(公告)日：2011-01-18
申请号：US12456927
申请日：2009-06-24
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US20090202628A1
公开(公告)日：2009-08-13
申请号：US12381091
申请日：2009-03-06
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/48 , A61K9/20 , A61K9/14 , A61K38/02 , A61K38/28 , A61K38/22 , A61K31/7105 , A61K31/727
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
摘要翻译： 本发明公开了由壳聚糖，聚谷氨酸和至少一种蛋白质药物或生物活性剂组成的纳米颗粒，其特征在于具有正表面电荷并且增强细胞外蛋白质药物和生物活性剂递送的渗透性。
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公开(公告)号：US20060147539A1
公开(公告)日：2006-07-06
申请号：US11284734
申请日：2005-11-21
申请人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K38/28 , A61K31/727 , A61K31/55 , A61K31/473 , A61K31/13 , A61K9/14
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K9/5192 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K47/61 , Y10S977/773 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
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公开(公告)号：US20060073210A1
公开(公告)日：2006-04-06
申请号：US11029082
申请日：2005-01-04
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/50
CPC分类号： A61K9/5146 , A61K9/0019 , A61K9/5161 , A61K31/13 , A61K31/473 , A61K31/55 , A61K31/7008 , A61K31/704 , A61K31/727 , A61K33/24 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： The invention discloses the nanoparticles composed of chitosan/poly-γ-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
摘要翻译： 本发明公开了由壳聚糖/聚-γ-谷氨酸组成的纳米颗粒，其特征在于具有阳性表面电荷并且通过Caco-2细胞提高细胞外药物递送的通透性。
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公开(公告)号：US07863257B2
公开(公告)日：2011-01-04
申请号：US12321113
申请日：2009-01-15
申请人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Hsiang-Fa Liang , Hosheng Tu
CPC分类号： A61K9/5146 , A61K9/0043 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US20090142405A1
公开(公告)日：2009-06-04
申请号：US12315611
申请日：2008-12-04
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A61K9/16 , A61K38/21 , A61K39/395 , A61P25/28
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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公开(公告)号：US07541046B1
公开(公告)日：2009-06-02
申请号：US12151230
申请日：2008-05-05
申请人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Yu-Hsin Lin , Hsiang-Fa Liang , Hosheng Tu
IPC分类号： A01J21/00
CPC分类号： A61K9/5146 , A61K9/19 , A61K9/4891 , A61K9/5161 , A61K31/13 , A61K31/445 , A61K31/55 , A61K47/61
摘要： The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
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