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公开(公告)号：US20110160452A1
公开(公告)日：2011-06-30
申请号：US13043420
申请日：2011-03-08
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmai Wei , Ronald L. Wolin
IPC分类号： C07D403/04 , C07D401/04 , C07D403/14 , C07D498/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
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公开(公告)号：US20110218338A1
公开(公告)日：2011-09-08
申请号：US13084226
申请日：2011-04-11
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： C07D403/14 , C07D403/04 , C07D413/14 , C07D405/14
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US20080194577A1
公开(公告)日：2008-08-14
申请号：US12070051
申请日：2008-02-14
申请人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
发明人： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC分类号： A61K31/496 , C07D239/48 , A61K31/505 , A61P37/08 , C07K14/705 , A61P17/00 , A61P29/00 , C07D403/04
CPC分类号： C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
摘要： 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
摘要翻译： 描述了2-氨基嘧啶化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
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公开(公告)号：US08937075B2
公开(公告)日：2015-01-20
申请号：US13456165
申请日：2012-04-25
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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公开(公告)号：US08927555B2
公开(公告)日：2015-01-06
申请号：US13456180
申请日：2012-04-25
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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6.发明申请THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 审中-公开组胺H4受体的THIENO-ADN FURO-PYRIMIDINE调节剂公开(公告)号：US20120214792A1
公开(公告)日：2012-08-23
申请号：US13456180
申请日：2012-04-25
IPC分类号： A61K31/519 , C07D491/048 , C07D243/08 , A61K31/551 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P9/10 , A61P19/02 , A61P1/00 , A61P1/04 , A61P17/06 , A61P17/00 , A61P37/06 , A61P7/06 , C07D495/04
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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公开(公告)号：US08445482B2
公开(公告)日：2013-05-21
申请号：US13456174
申请日：2012-04-25
IPC分类号： C07D243/08 , C07D491/147 , A61K31/5513 , A61K31/5025 , A61K31/501 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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8.发明申请THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 有权组胺H4受体的THIENO-和FURO-PYRIMIDINE调节剂公开(公告)号：US20120270855A1
公开(公告)日：2012-10-25
申请号：US13456174
申请日：2012-04-25
IPC分类号： A61K31/519 , A61P37/08 , A61P17/00 , A61P37/06 , A61P11/00 , A61P11/06 , A61P27/02 , A61P9/10 , A61P25/00 , A61P1/00 , A61P17/06 , A61P17/04 , C07D495/04 , C07D519/00 , C07D491/048 , A61K31/551 , C12N5/02 , A61P29/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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公开(公告)号：US20090075970A1
公开(公告)日：2009-03-19
申请号：US12283700
申请日：2008-09-12
IPC分类号： A61K31/519 , C07D495/04 , C07D493/04 , A61K31/551
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
摘要翻译： 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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公开(公告)号：US08440654B2
公开(公告)日：2013-05-14
申请号：US13456148
申请日：2012-04-25
IPC分类号： C07D491/04 , C07D243/08 , A61K31/519 , A61K31/5513 , A61K31/5025 , A61K31/501 , A61P29/00
CPC分类号： C07D495/04 , C07D493/04 , C07D519/00
摘要： Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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