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公开(公告)号：US07834024B2
公开(公告)日：2010-11-16
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US20080260754A1
公开(公告)日：2008-10-23
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K39/395 , C12N9/12 , C07D239/24 , A61K31/505 , C07D295/00 , A61K31/5377 , C07D498/02 , C12N5/00 , A61P37/00 , A61K31/5383 , C07D403/02 , A61K31/496 , C07D279/16 , A61K31/5415 , A61K38/13
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20110027856A1
公开(公告)日：2011-02-03
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： C12N9/99
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US08299087B2
公开(公告)日：2012-10-30
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US08415365B2
公开(公告)日：2013-04-09
申请号：US12030031
申请日：2008-02-12
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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公开(公告)号：US08399472B2
公开(公告)日：2013-03-19
申请号：US12193627
申请日：2008-08-18
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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公开(公告)号：US20090041786A1
公开(公告)日：2009-02-12
申请号：US12193627
申请日：2008-08-18
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： A61K31/505 , C07D239/48 , C07F7/10 , A61K31/695 , A61K31/538 , A61P37/06 , A61K39/395 , A61K31/5377 , C07D413/02 , C07D265/36
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
摘要翻译： 本发明包括具有式I-V的化合物和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制可能是治疗上有用的条件。
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公开(公告)号：US20060293311A1
公开(公告)日：2006-12-28
申请号：US11450901
申请日：2006-06-08
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： A61K31/549 , A61K31/506 , A61K31/505 , C07D417/02 , C07D403/02
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
摘要翻译： 本发明包括具有式I-V的化合物和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制可能是治疗上有用的条件。
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公开(公告)号：US20080306099A1
公开(公告)日：2008-12-11
申请号：US12030031
申请日：2008-02-12
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： A61K31/505 , C07D239/28
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
摘要翻译： 本发明包括具有式I-V的化合物和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制可能是治疗上有用的条件。
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公开(公告)号：US08962643B2
公开(公告)日：2015-02-24
申请号：US11678488
申请日：2007-02-23
申请人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
发明人： Hui Li , Ankush Argade , Kin Tso , Sambaiah Thota , David Carroll , Arvinder Sran , Robin Cooper , Rajinder Singh , Somasekhar Bhamidipati , Vanessa Taylor , Esteban Masuda
IPC分类号： C07D403/12 , A61K31/505 , C07D239/48 , C07D401/12 , C07D409/12 , C07D417/12
CPC分类号： C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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