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1.发明授权
公开(公告)号：US6126785A
公开(公告)日：2000-10-03
申请号：US301340
申请日：1999-04-29
申请人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
发明人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
CPC分类号： D21G9/0027 , D21F7/003 , Y10S162/10 , Y10S162/11
摘要： Significant improvements in papermaking control can be achieved by employing an array of sensors that are positioned underneath the wire of the machine to measure the conductivity of the aqueous wet stock. The conductivity of the wet stock is directly proportional to the total water weight within the wet stock; consequently, the sensor provides information which can be used to monitor and control the quality of the paper sheet produced. Because CD water weight profile is obtained practically instantaneously, the MD and CD variations are essentially decoupled. Quality improvements to the sheet fabricated will be achieved by providing fast control of the actuators on the machine and by tuning components on the machine to eliminate the sources of variations. Further, the dry stock weight of a sheet of wet stock that is resting on a water permeable moving wire of the papermaking machine can be made employing a water weight sensor element that is positioned adjacent to the wire and that generates signals indicative of the water weight of the sheet of wet stock on the wire. Moreover, the moisture level cross-direction (CD) profile of a sheet of material that is produced can also be measured.
摘要翻译： 通过使用位于机器线材下方的传感器阵列来测量水性湿料的导电性，可以实现造纸控制的显着改进。 湿料的电导率与湿料中的总水重量成正比; 因此，传感器提供可用于监测和控制所生产的纸张的质量的信息。 因为CD水重量曲线实际上是瞬间获得的，所以MD和CD变化基本上是去耦的。 通过对机器上的致动器进行快速控制，并通过调节机器上的组件来消除变化的来源，可以实现对制造的片材的质量改进。 此外，搁置在造纸机的透水移动金属线上的湿料片材的干燥储存重量可以使用位于铅丝附近的水重量传感器元件来制造，并产生指示水重量的信号 的电线上的湿股票。 此外，还可以测量所生产的材料片的湿度水平横向（CD）轮廓。
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2.发明授权公开(公告)号：US06168687A
公开(公告)日：2001-01-02
申请号：US09066802
申请日：1998-04-24
申请人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
发明人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
IPC分类号： D21F1100
CPC分类号： D21G9/0027 , D21F7/003 , Y10S162/10 , Y10S162/11
摘要： Significant improvements in papermaking control can be achieved by employing an array of sensors that are positioned underneath the wire of the machine to measure the conductivity of the aqueous wet stock. The conductivity of the wet stock is directly proportional to the total water weight within the wet stock; consequently, the sensor provides information which can be used to monitor and control the quality of the paper sheet produced. Because CD water weight profile is obtained practically instantaneously, the MD and CD variations are essentially decoupled. Quality improvements to the sheet fabricated will be achieved by providing fast control of the actuators on the machine and by tuning components on the machine to eliminate the sources of variations. Further, the dry stock weight of a sheet of wet stock that is resting on a water permeable moving wire of the papermaking machine can be made employing a water weight sensor element that is positioned adjacent to the wire and that generates signals indicative of the water weight of the sheet of wet stock on the wire. Moreover, the moisture level cross-direction (CD) profile of a sheet of material that is produced can also be measured.
摘要翻译： 通过使用位于机器线材下方的传感器阵列来测量水性湿料的导电性，可以实现造纸控制的显着改进。 湿料的电导率与湿料中的总水重量成正比; 因此，传感器提供可用于监测和控制所生产的纸张的质量的信息。 因为CD水重量曲线实际上是瞬间获得的，所以MD和CD变化基本上是去耦的。 通过对机器上的致动器进行快速控制，并通过调节机器上的组件来消除变化的来源，可以实现对制造的片材的质量改进。 此外，搁置在造纸机的透水移动金属线上的湿料片材的干燥储存重量可以使用位于铅丝附近的水重量传感器元件来制造，并产生指示水重量的信号 的电线上的湿股票。 此外，还可以测量所生产的材料片的湿度水平横向（CD）轮廓。
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公开(公告)号：US6059931A
公开(公告)日：2000-05-09
申请号：US301336
申请日：1999-04-29
申请人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
发明人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
CPC分类号： D21G9/0027 , D21F7/003 , Y10S162/10 , Y10S162/11
摘要： Significant improvements in papermaking control can be achieved by employing an array of sensors that are positioned underneath the wire of the machine to measure the conductivity of the aqueous wet stock. The conductivity of the wet stock is directly proportional to the total water weight within the wet stock; consequently, the sensor provides information which can be used to monitor and control the quality of the paper sheet produced. Because CD water weight profile is obtained practically instantaneously, the MD and CD variations are essentially decoupled. Quality improvements to the sheet fabricated will be achieved by providing fast control of the actuators on the machine and by tuning components on the machine to eliminate the sources of variations. Further, the dry stock weight of a sheet of wet stock that is resting on a water permeable moving wire of the papermaking machine can be made employing a water weight sensor element that is positioned adjacent to the wire and that generates signals indicative of the water weight of the sheet of wet stock on the wire. Moreover, the moisture level cross-direction (CD) profile of a sheet of material that is produced can also be measured.
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公开(公告)号：US6099690A
公开(公告)日：2000-08-08
申请号：US301341
申请日：1999-04-29
申请人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
发明人： Hung-Tzaw Hu , Lee Chase , John Goss , John Preston
CPC分类号： D21G9/0027 , D21F7/003 , Y10S162/10 , Y10S162/11
摘要： Significant improvements in papermaking control can be achieved by employing an array of sensors that are positioned underneath the wire of the machine to measure the conductivity of the aqueous wet stock. The conductivity of the wet stock is directly proportional to the total water weight within the wet stock; consequently, the sensor provides information which can be used to monitor and control the quality of the paper sheet produced. Because CD water weight profile is obtained practically instantaneously, the MD and CD variations are essentially decoupled. Quality improvements to the sheet fabricated will be achieved by providing fast control of the actuators on the machine and by tuning components on the machine to eliminate the sources of variations. Further, the dry stock weight of a sheet of wet stock that is resting on a water permeable moving wire of the papermaking machine can be made employing a water weight sensor element that is positioned adjacent to the wire and that generates signals indicative of the water weight of the sheet of wet stock on the wire. Moreover, the moisture level cross-direction (CD) profile of a sheet of material that is produced can also be measured.
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公开(公告)号：US6006602A
公开(公告)日：1999-12-28
申请号：US70165
申请日：1998-04-30
申请人： John Preston , Lee Chase , Hung-Tzaw Hu , John D. Goss
发明人： John Preston , Lee Chase , Hung-Tzaw Hu , John D. Goss
CPC分类号： G01G17/02
摘要： An apparatus and method for obtaining fiber weight measurements in the wet end of a sheetmaking system and for verifying fiber weight measurements taken in the wet end of a sheetmaking system which includes a water weight sensor positioned beneath the wire in the wet end of the sheetmaking system for obtaining water weight measurements and load cells residing beneath the water weight sensor for weighing the wet end sensor and the wire with wetstock (total weight) and without wetstock (tare weight). In one embodiment, the water weight measurement and the tare weight measurement are subtracted from the total weight to obtain the fiber weight in the wetstock. In another embodiment, the water weight measurement is used to obtain an predicted fiber weight measurement and the determined fiber weight is used to verify the predicted fiber weight measurement and the accuracy of the water weight measurement device.
摘要翻译： 一种用于在片材制造系统的湿端中获得纤维重量测量值的装置和方法，并用于验证在片材制造系统的湿端中进行的纤维重量测量，该测量系统包括定位在片材制造系统的湿端中的线下方的水重量传感器 用于获得水重量测量值和位于水重量传感器下方的称重传感器，用于称重湿端传感器和具有湿盘（总重量）和无湿料（皮重）的电线。 在一个实施例中，从总重量中减去水重量测量和皮重测量，以获得湿料中的纤维重量。 在另一个实施例中，使用水重量测量来获得预测的纤维重量测量值，并且使用确定的纤维重量来验证预测的纤维重量测量值和水重量测量装置的精度。
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公开(公告)号：US6092003A
公开(公告)日：2000-07-18
申请号：US93529
申请日：1998-06-08
CPC分类号： D21G9/0027
摘要： System and method for producing paper are provided. The system controls formation of wet stock comprising fibers on a moving water permeable wire of a de-watering machine that has a refiner that is subject to a variable load and a headbox having at least one slice, wherein each slice has an aperture through which wet stock is discharged at a stock jet speed onto the wire that is moving at a wire speed. A sheet of wet stock moving a speed develops on the wire. The system includes: a) at least two water weight sensors that are positioned adjacent to the wire wherein the at least two sensors are positioned at different locations in the direction of movement of the wire and upstream from a dry line which develops during operation of the machine and the sensors generate signals indicative of a water weight profile made up of a multiplicity of water weight measurements; and b) means for adjusting at least one of the stock jet speed, sheet speed, wire speed, or refiner load to cause the water weight profile to match a preselected or optimal water weight profile. Techniques for predicting the dry stock weight of wet stock on the wire can be employed to assess the effect of adjusting the operating parameters. In addition, employing two sensors placed in the machine direction, the sheet speed can be determined by measuring the water weigh profile of a segment of the sheet and the time required for the segment to travel from one sensor to the next.
摘要翻译： 提供纸的生产方法和制造方法。 该系统控制在脱水机的移动透水导线上形成含有纤维的湿料，所述脱水机具有经受可变负载的精磨机和具有至少一个切片的流浆箱，其中每个切片具有通过该孔的孔 原料以库存喷射速度排出到以线速度移动的线上。 在电线上形成一片移动速度的湿料。 所述系统包括：a）至少两个水重量传感器，其邻近所述导线定位，其中所述至少两个传感器位于所述导线的运动方向上的不同位置，并且在所述导线的运行过程中产生的干线上游 机器和传感器产生指示由多个水重量测量组成的水重分布的信号; 以及b）用于调节储存喷射速度，纸张速度，线速度或精磨机负载中的至少一个的装置，以使水重量分布匹配预选或最佳水重分布。 可以使用用于预测线材上湿料干燥料重的技术来评估调整操作参数的效果。 另外，使用沿机器方向放置的两个传感器，可以通过测量片材的片段的水分分布和片段从一个传感器传播到下一个传感器所需的时间来确定片材速度。
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公开(公告)号：US5928475A
公开(公告)日：1999-07-27
申请号：US933161
申请日：1997-09-18
申请人： Lee Chase , John D. Goss , Graham V. Walford , John Preston
发明人： Lee Chase , John D. Goss , Graham V. Walford , John Preston
IPC分类号： D21H23/08 , G01G9/00 , G01N27/02 , G01N27/04 , G01N27/22 , G01N33/34 , D21F11/00 , G01R27/02
CPC分类号： D21H23/08 , G01G9/00 , G01N33/343 , Y10S162/06 , Y10S162/11
摘要： A system and method that combine an array of fast under wire water weigh sensors with a scanning system provides an accurate measurement of the entire sheet down to 1 in. by 1 in. resolution. Because CD profiles are obtained instantaneously, MD and CD variations are completely decoupled, even if CD profiles are taken at longer intervals apart. The technique allows monitoring the basis weight of a sheet of material that is formed in a process that employs a de-watering machine that includes a water permeable moving fabric supporting wet stock and a dry end which technique includes the steps of: a) positioning an array of water weight sensor elements (array) underneath and adjacent to the fabric wherein the array is positioned in a cross direction to the moving fabric; b) positioning a scanning sensor at the dry end to measure the dry basis weight of the sheet of material; c) operating the machine and measuring the water weights of the sheet of material with the array and measuring the dry basis weight of the sheet of material with the scanning sensor at the dry end; d) developing a functional relationship between water weight of the sheet as measured by the array and the basis weight of the sheet which is formed after being substantially de-watered; end; and e) periodically, adjusting the functional relationship using readings from the scanning sensor to compensate for variations due to process parameters. The technique can further include the step of correlating positional readings of the scanning sensor with measurements from the corresponding element in the array to obtain separate calibration for each individual element of the array and step e comprises adjusting the functional relationship obtained in step d and the calibration obtained in to compensate for variations due to process parameters.
摘要翻译： 将快速下线水重传感器与扫描系统结合的系统和方法可以将整个纸张的精确测量精确到1英寸×1英寸分辨率。 由于CD配置文件被即时获得，所以MD和CD的变化是完全解耦的，即使以更长的间隔分开进行CD配置文件。 该技术允许监测在使用脱水机的过程中形成的一片材料的基重，所述脱水机包括支撑湿料的透水性移动织物和干燥端，该技术包括以下步骤：a） 排列在织物下方并邻近织物的水重量传感器元件（阵列），其中阵列沿与运动织物交叉的方向定位; b）将扫描传感器定位在干燥端以测量材料片的干基重量; c）操作机器并用阵列测量材料片的重量，并用干燥末端的扫描传感器测量材料片的干基重量; d）通过阵列测量的片材的水重与在基本上脱水后形成的片材的基重之间形成功能关系; 结束; 和e）周期性地使用来自扫描传感器的读数来调整功能关系，以补偿由于工艺参数引起的变化。 该技术还可以包括将扫描传感器的位置读数与阵列中相应元件的测量值相关的步骤，以获得阵列的每个单独元件的单独校准，步骤e包括调整步骤d中获得的功能关系和校准 获得以补偿由于工艺参数引起的变化。
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公开(公告)号：US06300330B1
公开(公告)日：2001-10-09
申请号：US09297768
申请日：1999-05-07
IPC分类号： A61K31496
CPC分类号： C07D213/73 , A61K31/44 , A61K31/505 , C07D213/56 , C07D213/61 , C07D213/84 , C07D213/89 , C07D237/08 , C07D239/26
摘要： The invention relates to heterocyclic derivatives of the formula (I): A—B—X1—T1(R2)—L1—T2(R3)—X2—Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to their inhibition of Factor Xa and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.
摘要翻译： 本发明涉及式（I）的杂环衍生物：AB-X1-T1（R2）-L1-T2（R3）-X2-Q或其药学上可接受的盐，由于它们抑制因子而具有抗血栓形成和抗凝血性质 因此，可用于治疗人或动物的方法。 本发明还涉及制备杂环衍生物的方法，含有它们的药物组合物及其在制备用于产生抗血栓形成或抗凝血作用的药物中的用途。
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公开(公告)号：US5110808A
公开(公告)日：1992-05-05
申请号：US738436
申请日：1991-07-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61P3/08 , A61P3/10 , A61P43/00 , C07C317/40 , C07C317/42 , C07D295/14 , C07D295/185
CPC分类号： C07D295/185 , C07C317/40 , C07C317/42
摘要： The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
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公开(公告)号：US4528282A
公开(公告)日：1985-07-09
申请号：US459143
申请日：1983-01-19
申请人： John Preston , William R. Carling
发明人： John Preston , William R. Carling
IPC分类号： C07D317/30 , A61K38/00 , A61K45/06 , A61P9/12 , C07D207/16 , C07D307/54 , C07D333/24 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07K5/02 , A61K37/00 , C07C103/52
CPC分类号： C07K5/0222 , A61K38/00 , Y10S530/80
摘要： Amide derivatives of the formula: ##STR1## wherein either R.sup.1 is aryl or heterocyclic and A.sup.1 is a direct link, or R.sup.1 is aryl or heterocyclic, or hydrogen, or halogeno, hydroxy, amino, guanidino, mercapto, carboxy, carbamoyl, or a substituted derivative thereof, and A.sup.1 is alkylene, alkenylene, cycloalkylene or cycloalkenylene; wherein X is carbonyl or hydroxymethylene or substituted derivatives thereof; wherein A.sup.2 is alkylene, alkenylene or alkylidene; wherein R.sup.2 is hydrogen or alkyl which is unsubstituted or which bears an aryl substituent, or R.sup.2 has the formula --Q.sup.2 --R.sup.20 as defined below; wherein R.sup.3 is hydrogen, alkyl or a carbonyl-containing group; wherein R.sup.4 is hydrogen or alkyl which is unsubstituted or which bears a halogeno, hydroxy, amino, guanidino, carboxy, carbamoyl, mercapto, alkoxy, alkylamino, dialkylamino, cyclic amino, alkylthio, alkanoylamino, alkoxycarbonylamino, alkoxycarbonyl, alkoxycarbonyl, aryl or heterocyclyl substituent;wherein --NR.sup.5 --CR.sup.6 R.sup.16 --Q.sup.1 --R.sup.10 is an amino acid residue, R.sup.5, R.sup.6 and R.sup.16 being defined in claim 1, wherein Q.sup.1 and Q.sup.2, which may be the same or different, each is carbonyl (--CO--) or methylene (--CH.sub.2 --); and wherein R.sup.10 and R.sup.20, which may be the same or different, is hydroxy, amino or a substituted derivative thereof or hydroxyamino or arylthio; or a salt thereof where appropriate; processes for their manufacture and pharmaceutical compositions containing them. The compounds are inhibitors of angiotensin converting enzyme and may be used in the treatment of hypertension.
摘要翻译： 下式的酰胺衍生物：其中R 1为芳基或杂环，且A 1为直链，或R 1为芳基或杂环，或氢或卤素，羟基，氨基，胍基，巯基，羧基，氨基甲酰基或 取代衍生物，A1为亚烷基，亚烯基，亚环烷基或环亚烯基; 其中X是羰基或羟基亚甲基或其取代的衍生物; 其中A2是亚烷基，亚烯基或亚烷基; 其中R 2是氢或未被取代或带有芳基取代基的烷基，或R 2具有如下定义的式-Q 2 -R 20; 其中R3是氢，烷基或含羰基的基团; 羟基，氨基，胍基，羧基，氨基甲酰基，巯基，烷氧基，烷基氨基，二烷基氨基，环状氨基，烷硫基，烷酰基氨基，烷氧基羰基氨基，烷氧基羰基，烷氧基羰基，芳基或杂环基取代基 ; 其中-NR5-CR6R16-Q1-R10是氨基酸残基，R5，R6和R16如权利要求1所定义，其中Q1和Q2可以相同或不同，分别为羰基（-CO-）或亚甲基（-CO-） -CH2-）; 并且其中R10和R20可以相同或不同，为羟基，氨基或其取代的衍生物或羟基氨基或芳硫基; 或其盐; 其制造方法和含有它们的药物组合物。 该化合物是血管紧张素转换酶的抑制剂，可用于治疗高血压。
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