利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.035 秒)

    Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
    4.
    发明申请
    Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors 有权
    新型三唑衍生物作为生长激素促分泌受体的生长素释放肽类似物配体

    公开(公告)号：US20070037857A1

    公开(公告)日：2007-02-15

    申请号：US11502473

    申请日：2006-08-11

    申请人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    发明人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    IPC分类号： A61K31/4439 ,  A61K31/4196

    CPC分类号： A61K31/4439 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/497 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  A61K2300/00

    摘要： The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

    摘要翻译： 本发明提供新颖的三唑衍生物作为根据式（I）的生长激素促分泌素受体的生长素释放肽类似物配体，其可用于治疗或预防由GHS受体介导的哺乳动物，优选人类的生理和/或病理生理学状况。 本发明还提供了可用于调节这些受体的GHS受体拮抗剂和激动剂，并且可用于治疗上述病症，特别是生长迟缓，恶病质，短期，中期和/或长期调节能量平衡; 短期，中期和/或长期调节（刺激和/或抑制）食物摄入; 脂肪形成，肥胖和/或肥胖; 体重增加和/或减少; 糖尿病，I型糖尿病，II型糖尿病，肿瘤细胞增殖; 炎症，炎症反应，胃后肠梗阻，术后肠梗阻和/或胃切除术（生长激素释放肽替代疗法）。

    Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
    5.
    发明授权
    Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors 有权
    三唑衍生物作为生长激素促分泌受体的生长素释放肽类似物配体

    公开(公告)号：US08710089B2

    公开(公告)日：2014-04-29

    申请号：US12880774

    申请日：2010-09-13

    申请人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    发明人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    IPC分类号： A01N43/64 ,  A61K31/41 ,  C07D249/08

    CPC分类号： A61K31/4439 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/497 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  A61K2300/00

    摘要： The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

    摘要翻译： 本发明提供新颖的三唑衍生物作为根据式（I）的生长激素促分泌素受体的生长素释放肽类似物配体，其可用于治疗或预防由GHS受体介导的哺乳动物，优选人类的生理和/或病理生理学状况。 本发明还提供了可用于调节这些受体的GHS受体拮抗剂和激动剂，并且可用于治疗上述病症，特别是生长迟缓，恶病质，短期，中期和/或长期调节能量平衡; 短期，中期和/或长期调节（刺激和/或抑制）食物摄入; 脂肪形成，肥胖和/或肥胖; 体重增加和/或减少; 糖尿病，I型糖尿病，II型糖尿病，肿瘤细胞增殖; 炎症，炎症反应，胃后肠梗阻，术后肠梗阻和/或胃切除术（生长激素释放肽替代疗法）。

    Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
    6.
    发明授权
    Triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors 有权
    三唑衍生物作为生长激素促分泌受体的生长素释放肽类似物配体

    公开(公告)号：US07829724B2

    公开(公告)日：2010-11-09

    申请号：US11502473

    申请日：2006-08-11

    申请人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    发明人： Daniel Perrissoud ,  Jean Martinez ,  Aline Moulin ,  Jean-Alain Fehrentz ,  Damien Boeglin ,  Luc Demange

    IPC分类号： C07D249/08 ,  A01N43/64 ,  A61K31/41

    CPC分类号： A61K31/4439 ,  A61K31/4196 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/497 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  A61K2300/00

    摘要： The present invention provides novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular growth retardation, cachexia, short-, medium- and/or long term regulation of energy balance; short-, medium- and/or long term regulation (stimulation and/or inhibition) of food intake; adipogenesis, adiposity and/or obesity; body weight gain and/or reduction; diabetes, diabetes type I, diabetes type II, tumor cell proliferation; inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

    摘要翻译： 本发明提供新颖的三唑衍生物作为根据式（I）的生长激素促分泌素受体的生长素释放肽类似物配体，其可用于治疗或预防由GHS受体介导的哺乳动物，优选人类的生理和/或病理生理学状况。 本发明还提供了可用于调节这些受体的GHS受体拮抗剂和激动剂，并且可用于治疗上述病症，特别是生长迟缓，恶病质，短期，中期和/或长期调节能量平衡; 短期，中期和/或长期调节（刺激和/或抑制）食物摄入; 脂肪形成，肥胖和/或肥胖; 体重增加和/或减少; 糖尿病，I型糖尿病，II型糖尿病，肿瘤细胞增殖; 炎症，炎症反应，胃后肠梗阻，术后肠梗阻和/或胃切除术（生长激素释放肽替代疗法）。