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    Optical monitoring of cleaving enzyme activity
    1.
    发明授权
    Optical monitoring of cleaving enzyme activity 失效
    光学监测切割酶活性

    公开(公告)号：US07521188B2

    公开(公告)日：2009-04-21

    申请号：US11070568

    申请日：2005-03-02

    申请人： Hyoungsik Yim ,  Mark E. Meyerhoff ,  Youngmi Lee

    发明人： Hyoungsik Yim ,  Mark E. Meyerhoff ,  Youngmi Lee

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/47

    CPC分类号： C12Q1/37 ,  C12Q1/34 ,  G01N2333/922

    摘要： A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor labeled peptide, or a co-factor labeled oligonucleotide. The co-factor is adapted to produce an enzymatic signal that is optically detectable.

    摘要翻译： 公开了一种用于监测切割酶活性的标记分子。 标记分子包括蛋白质，肽或寡核苷酸。 辅因子与蛋白质，肽或寡核苷酸结合，从而形成辅因子标记的蛋白质，辅因子标记肽或辅因子标记的寡核苷酸。 辅因子适于产生可光学检测的酶信号。

    Low maintenance reference electrode for electrochemical measurements
    5.
    发明授权
    Low maintenance reference electrode for electrochemical measurements 有权
    用于电化学测量的低维护参比电极

    公开(公告)号：US08172999B2

    公开(公告)日：2012-05-08

    申请号：US12541476

    申请日：2009-08-14

    申请人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    发明人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    IPC分类号： G01N27/26

    CPC分类号： G01N27/4035 ,  G01N27/301 ,  G01N33/18 ,  G01N33/49

    摘要： A low maintenance reference electrode has a liquid junction body with a multiplicity of micron-sized capillary channels extending through the body for transporting electrolyte to a test solution. A viscosity-increasing agent thickens the electrolyte to limit its flow to a rate on the order of microliters/day so that a few milliliters of electrolyte suffice to provide an extended electrode life.

    摘要翻译： 低维护参考电极具有液体接合体，其具有延伸穿过主体的多个微米级毛细通道，用于将电解质输送到测试溶液。 粘度增加剂使电解液增稠以将其流动限制在微升/天的数量级，使得几毫升的电解液足以提供延长的电极寿命。

    Electrochemically and optically monitoring cleaving enzyme activity
    6.
    发明申请
    Electrochemically and optically monitoring cleaving enzyme activity 审中-公开
    电化学和光学监测切割酶活性

    公开(公告)号：US20060199241A1

    公开(公告)日：2006-09-07

    申请号：US11264288

    申请日：2005-11-01

    申请人： Hyoungsik Yim ,  Mark Meyerhoff ,  Dongxuan Shen ,  Sangyeul Hwang

    发明人： Hyoungsik Yim ,  Mark Meyerhoff ,  Dongxuan Shen ,  Sangyeul Hwang

    IPC分类号： C12Q1/37 ,  C07K14/47 ,  C07K14/80

    CPC分类号： C12Q1/005 ,  C07K1/13 ,  C12Q1/34 ,  G01N2333/922

    摘要： A marker molecule for monitoring cleaving enzyme activity is disclosed. The marker molecule includes a protein, a peptide, or an oligonucleotide. A co-factor is conjugated to the protein, the peptide, or the oligonucleotide, thereby forming a co-factor labeled protein, a co-factor labeled peptide, or a co-factor labeled oligonucleotide. The co-factor is adapted to produce an enzymatic signal that is at least one of electrochemically and optically detectable.

    摘要翻译： 公开了一种用于监测切割酶活性的标记分子。 标记分子包括蛋白质，肽或寡核苷酸。 辅因子与蛋白质，肽或寡核苷酸结合，从而形成辅因子标记的蛋白质，辅因子标记肽或辅因子标记的寡核苷酸。 辅因子适于产生至少一种电化学和光学可检测的酶信号。

    Temperature compensation for ion-selective electrodes
    7.
    发明授权
    Temperature compensation for ion-selective electrodes 有权
    离子选择电极的温度补偿

    公开(公告)号：US08287705B2

    公开(公告)日：2012-10-16

    申请号：US12692740

    申请日：2010-01-25

    申请人： Moshe Hirshberg ,  Xiaowen Wen ,  Hyoungsik Yim ,  Dawood Bhaijee

    发明人： Moshe Hirshberg ,  Xiaowen Wen ,  Hyoungsik Yim ,  Dawood Bhaijee

    IPC分类号： G01N27/333

    CPC分类号： G01N27/333

    摘要： Temperature compensation for ion-selective electrodes is obtained by positioning a temperature-measuring element in a chamber of limited thermal mass which is in thermal contact with the measuring electrode filling solution but is thermally isolated from other filling solutions in the electrode. In a preferred embodiment, the temperature-measuring element comprises a thermistor enclosed within thin flexible tubing; the electrical leads of the thermistor are forced against a segment of the inner wall of the tubing by an elongated strand of material abutting the thermistor to enhance heat transfer with the thermistor.

    摘要翻译： 离子选择电极的温度补偿通过将温度测量元件放置在与测量电极填充溶液热接触但与电极中的其它填充溶液热隔离的有限热质量室中来获得。 在优选实施例中，温度测量元件包括封装在薄柔性管内的热敏电阻; 热敏电阻的电引线通过与热敏电阻邻接的细长材料束而被迫靠在管道的内壁的一段上，以增强与热敏电阻的热传递。

    LOW MAINTENANCE REFERENCE ELECTRODE FOR ELECTROCHEMICAL MEASUREMENTS
    8.
    发明申请
    LOW MAINTENANCE REFERENCE ELECTRODE FOR ELECTROCHEMICAL MEASUREMENTS 有权
    用于电化学测量的低维护参考电极

    公开(公告)号：US20120205245A1

    公开(公告)日：2012-08-16

    申请号：US13455727

    申请日：2012-04-25

    申请人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    发明人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    IPC分类号： G01N27/30 ,  G01N27/36

    CPC分类号： G01N27/4035 ,  G01N27/301 ,  G01N33/18 ,  G01N33/49

    摘要： A low maintenance reference electrode has a liquid junction body with a multiplicity of micron-sized capillary channels extending through the body for transporting electrolyte to a test solution. A viscosity-increasing agent thickens the electrolyte to limit its flow to a rate on the order of microliters/day so that a few milliliters of electrolyte suffice to provide an extended electrode life.

    摘要翻译： 低维护参考电极具有液体接合体，其具有延伸穿过主体的多个微米级毛细通道，用于将电解质输送到测试溶液。 粘度增加剂使电解液增稠以将其流动限制在微升/天的数量级，使得几毫升的电解液足以提供延长的电极寿命。

    TEMPERATURE COMPENSATION FOR ION-SELECTIVE ELECTRODES
    9.
    发明申请
    TEMPERATURE COMPENSATION FOR ION-SELECTIVE ELECTRODES 有权
    离子选择电极的温度补偿

    公开(公告)号：US20110180406A1

    公开(公告)日：2011-07-28

    申请号：US12692740

    申请日：2010-01-25

    申请人： Moshe Hirshberg ,  Xiaowen Wen ,  Hyoungsik Yim ,  Dawood Bhaijee

    发明人： Moshe Hirshberg ,  Xiaowen Wen ,  Hyoungsik Yim ,  Dawood Bhaijee

    IPC分类号： G01N27/333

    CPC分类号： G01N27/333

    摘要： Temperature compensation for ion-selective electrodes is obtained by positioning a temperature-measuring element in a chamber of limited thermal mass which is in thermal contact with the measuring electrode filling solution but is thermally isolated from other filling solutions in the electrode. In a preferred embodiment, the temperature-measuring element comprises a thermistor enclosed within thin flexible tubing; the electrical leads of the thermistor are forced against a segment of the inner wall of the tubing by an elongated strand of material abutting the thermistor to enhance heat transfer with the thermistor.

    摘要翻译： 离子选择电极的温度补偿通过将温度测量元件放置在与测量电极填充溶液热接触但与电极中的其它填充溶液热隔离的有限热质量室中来获得。 在优选实施例中，温度测量元件包括封装在薄柔性管内的热敏电阻; 热敏电阻的电引线通过与热敏电阻邻接的细长材料束而被迫靠在管道的内壁的一段上，以增强与热敏电阻的热传递。

    LOW MAINTENANCE REFERENCE ELECTRODE FOR ELECTROCHEMICAL MEASUREMENTS
    10.
    发明申请
    LOW MAINTENANCE REFERENCE ELECTRODE FOR ELECTROCHEMICAL MEASUREMENTS 有权
    用于电化学测量的低维护参考电极

    公开(公告)号：US20100038237A1

    公开(公告)日：2010-02-18

    申请号：US12541476

    申请日：2009-08-14

    申请人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    发明人： Xiaowen Wen ,  Hyoungsik Yim ,  Lori Hrdy ,  Dawood Bhaijee

    IPC分类号： C25B11/03

    CPC分类号： G01N27/4035 ,  G01N27/301 ,  G01N33/18 ,  G01N33/49

    摘要： A low maintenance reference electrode has a liquid junction body with a multiplicity of micron-sized capillary channels extending through the body for transporting electrolyte to a test solution. A viscosity-increasing agent thickens the electrolyte to limit its flow to a rate on the order of microliters/day so that a few milliliters of electrolyte suffice to provide an extended electrode life.

    摘要翻译： 低维护参考电极具有液体接合体，其具有延伸穿过主体的多个微米级毛细通道，用于将电解质输送到测试溶液。 粘度增加剂使电解液增稠以将其流动限制在微升/天的数量级，使得几毫升的电解液足以提供延长的电极寿命。