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    RECOMBINANT ALBUMINS FUSED WITH POLY-CYSTEINE PEPTIDE AND THE METHODS FOR PREPARING THE SAME
    1.
    发明申请
    RECOMBINANT ALBUMINS FUSED WITH POLY-CYSTEINE PEPTIDE AND THE METHODS FOR PREPARING THE SAME 有权
    与聚胞苷肽融合的重组脂质体及其制备方法

    公开(公告)号：US20100310468A1

    公开(公告)日：2010-12-09

    申请号：US12792186

    申请日：2010-06-02

    申请人： Hyung Jun AHN ,  Ick Chan KWON ,  Kuiwon CHOI ,  Kwangmyeng KIM ,  Inchan YOUN ,  Sehoon KIM

    发明人： Hyung Jun AHN ,  Ick Chan KWON ,  Kuiwon CHOI ,  Kwangmyeng KIM ,  Inchan YOUN ,  Sehoon KIM

    IPC分类号： C07K14/76 ,  A61K47/48 ,  C12N15/81 ,  C12N1/19 ,  C12P21/02 ,  A61K49/00

    CPC分类号： C07K14/76 ,  A61K47/643 ,  C07K14/765 ,  C07K2319/20

    摘要： The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto. In addition, the recombinant albumin of the present invention can be used for the screening of a novel drug and for the non-invasive real-time diagnosis and treatment of disease by combining with a fluorescent material or a contrast agent for molecular imaging.

    摘要翻译： 本发明涉及与多聚半胱氨酸肽融合的重组白蛋白及其制备方法，更准确地说，重组白蛋白，其中可用于药物结合的半胱氨酸在白蛋白的N末端和C末端扩增， 准备一样 本发明的重组白蛋白在用于药物递送系统时表现出改善的白蛋白 - 药物共轭效率，表明其可有效地将大量药物递送至靶组织。 同时，与常规白蛋白载体相比，本发明的重组白蛋白可以用作优异的药物递送剂，通过调节半胱氨酸数目调节与每单位白蛋白结合的药物的量 融合。 此外，本发明的重组白蛋白可以用于筛选新药和用于分子成像的荧光材料或造影剂的非侵入性实时诊断和治疗疾病。

    NANOPARTICLES OF LIGHT EMISSIVE POLYMERS AND PREPARATION METHOD THEREOF
    2.
    发明申请
    NANOPARTICLES OF LIGHT EMISSIVE POLYMERS AND PREPARATION METHOD THEREOF 有权
    光散射聚合物纳米微粒及其制备方法

    公开(公告)号：US20100290999A1

    公开(公告)日：2010-11-18

    申请号：US12576193

    申请日：2009-10-08

    申请人： Sehoon KIM ,  Ick Chan KWON ,  Kwangmeyung KIM ,  Kuiwon CHOI ,  Chang-Keun LIM

    发明人： Sehoon KIM ,  Ick Chan KWON ,  Kwangmeyung KIM ,  Kuiwon CHOI ,  Chang-Keun LIM

    IPC分类号： A61K49/00 ,  C08G14/02 ,  C12Q1/02

    CPC分类号： A61K49/0019 ,  A61K49/0093

    摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.

    摘要翻译： 公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由 通式NC-Ar2-CN，和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。 本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。