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公开(公告)号：US12226555B2
公开(公告)日：2025-02-18
申请号：US17622482
申请日：2020-06-26
Applicant: I-SEP
Inventor： Francis Gadrat , Benoît Decouture , Stéphane Chollet , Patricia Forest-Villegas , Sylvain Picot
Abstract: A method and system for treating, by filtration, haemorrhagic fluid contained in a container with a view to subsequent autotransfusion, including at least one step of concentrating by filtration said haemorrhagic fluid in order to increase the concentration of red blood cells in the haemorrhagic fluid to reach a target haematocrit level while at the same time removing from the haemorrhagic fluid a filtrate comprising compounds not desired for autotransfusion, further including: a preliminary step of measuring the haematocrit level of the haemorrhagic fluid; and a dilution step consisting in adding to the volume of haemorrhagic fluid to be treated a determined volume of dilution fluid, the determined volume of dilution fluid being calculated as a function of the measured haematocrit level of the haemorrhagic fluid and the target haematocrit level.
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2.发明公开公开(公告)号：US20230280331A1
公开(公告)日：2023-09-07
申请号：US18004399
申请日：2021-07-08
Applicant: I-SEP
Inventor： Stéphane Chollet , Gaëtan Coulon , Benoît Decouture , Sylvain Picot , Patricia Forest-Villegas , Francis Gadrat
CPC classification number: G01N33/4915 , G01N21/84 , G01N21/255 , A61M1/3609 , A61M2205/3306 , A61M2230/207 , G01N2201/069
Abstract: The invention relates to a device and method for determining the haematocrit and/or haemoglobin level of a liquid flowing in a tubular portion (2), the method comprising:—emitting light beams in the direction of the tubular portion (2) with at least two light sources (11; 21), each of the two light sources (11; 21) being configured to emit light beams at an emission wavelength chosen to correspond to an isobestic point of the haemoglobin;—receiving light signals transmitted through the tubular portion (2) with at least two light sensors (12; 22), each light sensor (12; 22) being associated with one of the two light sources (11; 21);—calculating the haematocrit or haemoglobin level in the liquid by processing the light signals received by the light sensors (12; 22); characterised in that the emission power of at least one of the light sources (11; 21) is modified while the haematocrit and/or the haemoglobin level is determined according to the haematocrit and/or respectively the haemoglobin level calculated for the liquid.
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3.发明公开公开(公告)号：US20230347036A1
公开(公告)日：2023-11-02
申请号：US18004547
申请日：2021-07-08
Applicant: I-SEP
Inventor： Stéphane Chollet , Gaëtan Coulon , Benoît Decouture , Sylvain Picot , Patricia Forest-Villegas , Francis Gadrat
IPC: A61M1/36
CPC classification number: A61M1/3609 , A61M2205/3306 , A61M2230/207
Abstract: A device for determining the level of haematocrit and/or the level of haemoglobin of a liquid circulating in the tubular portion includes two emitter-receiver assemblies, each emitter-receiver assembly including a light source and a light sensor intended to be arranged on either side of the tubular portion at a region of circulation of the liquid for a transmission measurement; the light source of each of the two emitter-receiver assemblies being configured to emit light beams at an emission wavelength chosen to correspond with an isobestic point of haemoglobin; each emitter-receiver assembly further comprising including a system for collimating the light beam emitted from the corresponding light source towards the corresponding light sensor.
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公开(公告)号：US11583615B2
公开(公告)日：2023-02-21
申请号：US16958473
申请日：2018-12-21
Applicant: I-SEP
Inventor： Francis Gadrat , Stéphane Chollet , Sylvain Picot , Patricia Forest-Villegas
Abstract: The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids; a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110), a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); and a first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
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Patent Agency Ranking
公开(公告)号：US20210060219A1
公开(公告)日：2021-03-04
申请号：US16958473
申请日：2018-12-21
Applicant: I-SEP
Inventor： Francis Gadrat , Stéphane Chollet , Sylvain Picot , Patricia Forest-Villegas
Abstract: The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids; a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110), a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); and a first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
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公开(公告)号：US20210052789A1
公开(公告)日：2021-02-25
申请号：US16958458
申请日：2018-12-21
Applicant: I-SEP
Inventor： Francis Gadrat , Stéphane Chollet , Sylvain Picot , Patricia Forest-Villegas
Abstract: The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids; a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110); a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); and a first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
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公开(公告)号：US11607478B2
公开(公告)日：2023-03-21
申请号：US16958458
申请日：2018-12-21
Applicant: I-SEP
Inventor： Francis Gadrat , Stéphane Chollet , Sylvain Picot , Patricia Forest-Villegas
Abstract: The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids; a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110); a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); and a first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).
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公开(公告)号：US20220378987A1
公开(公告)日：2022-12-01
申请号：US17776097
申请日：2020-11-10
Applicant: I-SEP
Inventor： Adrien Fiorino , Sylvain Picot
Abstract: The invention relates to an automatic valve for regulating a flow rate of liquid intended to circulate in a flexible tube, comprising: a cam system (23) mounted moveably on a base and rotationally around an axis of rotation, a bearing part (24) translationally mounted on the base, arranged to be translationally moved as a result of a rotational movement of the cam system (23), and comprising a compression portion (240), an abutment part (25) positioned opposite the compression portion (240), defining with the bearing part (24) a receiving space intended to receive a flexible tube (3), the translation of the bearing part (24) displacing the compression portion (240) along the direction of translation, in order to modify a dimension of the receiving space, a magnet and a magnetic sensor detecting the magnetic field generated by the magnet.
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公开(公告)号：US20220241473A1
公开(公告)日：2022-08-04
申请号：US17622482
申请日：2020-06-26
Applicant: I-SEP
Inventor： Francis Gadrat , Benoît Decouture , Stéphane Chollet , Patricia Forest-Villegas , Sylvain Picot
IPC: A61M1/02
Abstract: A method and system for treating, by filtration, haemorrhagic fluid contained in a container with a view to subsequent autotransfusion, including at least one step of concentrating by filtration said haemorrhagic fluid in order to increase the concentration of red blood cells in the haemorrhagic fluid to reach a target haematocrit level while at the same time removing from the haemorrhagic fluid a filtrate comprising compounds not desired for autotransfusion, further including: a preliminary step of measuring the haematocrit level of the haemorrhagic fluid; and a dilution step consisting in adding to the volume of haemorrhagic fluid to be treated a determined volume of dilution fluid, the determined volume of dilution fluid being calculated as a function of the measured haematocrit level of the haemorrhagic fluid and the target haematocrit level.
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