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公开(公告)号:US20130005968A1
公开(公告)日:2013-01-03
申请号:US13615894
申请日:2012-09-14
申请人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand R. Kulkarni
发明人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand R. Kulkarni
IPC分类号: C07F5/04
CPC分类号: C07K5/06191 , C07F5/025 , C07F5/04 , Y02P20/55
摘要: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
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公开(公告)号:US08283467B2
公开(公告)日:2012-10-09
申请号:US12706063
申请日:2010-02-16
申请人: Vince Ammoscato , John E. Bishop , Fang-Ting Chiu , Achim Geiser , Jean-Marc Gomez , Robert Hett , Christoph Koellner , Vithalanand R. Kulkarni , Young Lo , Stephen Munk , I. Fraser Pickersgill
发明人: Vince Ammoscato , John E. Bishop , Fang-Ting Chiu , Achim Geiser , Jean-Marc Gomez , Robert Hett , Christoph Koellner , Vithalanand R. Kulkarni , Young Lo , Stephen Munk , I. Fraser Pickersgill
IPC分类号: C07F5/02
CPC分类号: C07K5/06191 , C07F5/025 , C07F5/04 , Y02P20/55
摘要: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
摘要翻译: 本发明涉及硼酸酯和酸化合物的合成。 更具体地,本发明提供了用于大规模生产硼酸酯和酸化合物的改进的合成方法,包括肽硼酸蛋白酶体抑制剂硼替佐米。
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公开(公告)号:US20100174072A1
公开(公告)日:2010-07-08
申请号:US12706063
申请日:2010-02-16
申请人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand R. Kulkarni
发明人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand R. Kulkarni
IPC分类号: C07F5/04
CPC分类号: C07K5/06191 , C07F5/025 , C07F5/04 , Y02P20/55
摘要: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
摘要翻译: 本发明涉及硼酸酯和酸化合物的合成。 更具体地,本发明提供了用于大规模生产硼酸酯和酸化合物的改进的合成方法,包括肽硼酸蛋白酶体抑制剂硼替佐米。
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公开(公告)号:US20050240047A1
公开(公告)日:2005-10-27
申请号:US11088667
申请日:2005-03-24
申请人: I. Pickersgill , John Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand Kulkarni
发明人: I. Pickersgill , John Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett , Vince Ammoscato , Stephen Munk , Young Lo , Fang-Ting Chiu , Vithalanand Kulkarni
CPC分类号: C07K5/06191 , C07F5/025 , C07F5/04 , Y02P20/55
摘要: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
摘要翻译: 本发明涉及硼酸酯和酸化合物的合成。 更具体地,本发明提供了用于大规模生产硼酸酯和酸化合物的改进的合成方法,包括肽硼酸蛋白酶体抑制剂硼替佐米。
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公开(公告)号:US07714159B2
公开(公告)日:2010-05-11
申请号:US11088667
申请日:2005-03-24
申请人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett
发明人: I. Fraser Pickersgill , John E. Bishop , Christoph Koellner , Jean-Marc Gomez , Achim Geiser , Robert Hett
IPC分类号: C07F558/288
CPC分类号: C07K5/06191 , C07F5/025 , C07F5/04 , Y02P20/55
摘要: The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.
摘要翻译: 本发明涉及硼酸酯和酸化合物的合成。 更具体地,本发明提供了用于大规模生产硼酸酯和酸化合物(包括肽硼酸蛋白酶体抑制剂硼替佐米)的改进的合成方法。
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公开(公告)号:US07214799B2
公开(公告)日:2007-05-08
申请号:US11054527
申请日:2005-02-09
申请人: Raja Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
发明人: Raja Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
IPC分类号: C07D213/62
CPC分类号: C07D213/66 , C07D213/67 , C07D401/06 , C07D401/12
摘要: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
摘要翻译: 本发明提供了用于大规模生产吡哆胺(I)(4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶)的非氧化方法及其盐。 本发明还提供了用于合成吡哆胺的中间体化合物,以及用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。
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公开(公告)号:US20100305162A1
公开(公告)日:2010-12-02
申请号:US12855108
申请日:2010-08-12
申请人: Raja Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
发明人: Raja Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
IPC分类号: A61K31/444 , C07D213/66 , A61K31/44 , A61P3/10 , A61P3/06 , A61P13/12 , A61P25/00 , A61P27/02 , A61P9/10
CPC分类号: C07D213/66 , C07D213/67 , C07D401/06 , C07D401/12
摘要: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
摘要翻译: 本发明提供了用于大规模生产吡哆胺(I)(4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶)的非氧化方法及其盐。 本发明还提供了用于合成吡哆胺的中间体化合物,以及用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。
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公开(公告)号:US20070161678A1
公开(公告)日:2007-07-12
申请号:US11725094
申请日:2007-03-16
IPC分类号: A61K31/444 , A61K31/4415 , C07D211/72
CPC分类号: C07D213/66 , C07D213/67 , C07D401/06 , C07D401/12
摘要: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): (I), and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
摘要翻译: 本发明提供了用于大规模生产吡哆胺(I)(4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶):(I)的非氧化方法及其盐。 本发明还提供了用于合成吡哆胺的中间体化合物,以及用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。
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公开(公告)号:US08431712B2
公开(公告)日:2013-04-30
申请号:US12855108
申请日:2010-08-12
申请人: Raja G. Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
发明人: Raja G. Khalifah , Roland Keilitz , Christoph Koellner , Thorsten Degenhardt , Stephen Robert Brand
IPC分类号: C07D213/62
CPC分类号: C07D213/66 , C07D213/67 , C07D401/06 , C07D401/12
摘要: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): and salts thereof. The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
摘要翻译: 本发明提供了用于大规模生产吡哆胺(I)(4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶)的非氧化方法及其盐。 本发明还提供了用于合成吡哆胺的中间体化合物,以及用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。
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公开(公告)号:US20050272781A1
公开(公告)日:2005-12-08
申请号:US11054527
申请日:2005-02-09
IPC分类号: A61K31/4415 , C07D213/62 , C07D213/66 , C07D213/67 , C07D401/12
CPC分类号: C07D213/66 , C07D213/67 , C07D401/06 , C07D401/12
摘要: The invention provides non-oxidative methods for the large scale manufacture of pyridoxamine (I) (4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine): The invention also provides intermediate compounds for the synthesis of pyridoxamine, as well as compositions and methods for the treatment and/or prevention of conditions associated with the formation of post-Amadori advanced glycation end-products.
摘要翻译: 本发明提供用于大规模生产吡哆胺(I)(4-氨基甲基-3-羟基-5-羟甲基-2-甲基吡啶)的非氧化方法:本发明还提供用于合成吡哆胺的中间体化合物,以及 用于治疗和/或预防与后阿马多后期糖基化终产物形成相关的病症的组合物和方法。
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