公开(公告)号：US20220283087A1

公开(公告)日：2022-09-08

申请号：US17653281

申请日：2022-03-02

Applicant: Illumina, Inc.

Inventor： Mohsen REZAEI ,  Michael BUREK ,  Arvin Emadi ,  Ludovic VINCENT

IPC: G01N21/64 ,  G01N33/543

Abstract: There is set forth herein, in one example, an apparatus. The apparatus can comprise, for example: a first reaction site and a second reaction site over a single pixel. There is set forth herein, in one example, a method. The method can include, for example: detecting a signal emitted from a first reaction site and a second reaction site; determining the identity of a first analyte of interest in a first reaction site using an amplitude of the detected signal; and determining the identity of a second analyte of interest in a second reaction site using the amplitude of the detected signal.

公开(公告)号：US20230333017A1

公开(公告)日：2023-10-19

申请号：US18297891

申请日：2023-04-10

Applicant: ILLUMINA, INC.

Inventor： Tara BOZORG-GRAYELI ,  Ravi BILLA ,  Tracy FUNG ,  Mohsen REZAEI ,  Craig Hetherington ,  Paul Sangiorgio ,  Craig Ciesia ,  Arvin Emadi

IPC: G01N21/64 ,  H01L27/146

CPC classification number: G01N21/6428 ,  H01L27/14623 ,  G01N21/6454 ,  H01L27/14689

Abstract: Provided herein are various examples of aspects of a biosensor and methods for manufacturing and using aspects of a biosensor. The method of manufacturing may include forming a germanium layer above a surface of an image sensor and forming a dielectric stack above a surface of the germanium layer. The biosensor can be utilized by placing nucleic acid(s) in reaction sites of the biosensor, exposing the reaction sites to light from a light source (e.g., excitation light), receiving emitted light from the reaction sites via the germanium layer, and identifying, based on the emitted light, a composition of the one or more nucleic acids.

公开(公告)号：US20240319164A1

公开(公告)日：2024-09-26

申请号：US18575213

申请日：2022-08-30

Applicant: ILLUMINA, INC.

Inventor： Xu LIU ,  Mohsen REZAEI ,  Arvin EMADI

IPC: G01N33/487 ,  C12Q1/6869

CPC classification number: G01N33/48721 ,  C12Q1/6869

Abstract: In one aspect, the disclosed technology relates to systems and methods for sequencing polynucleotides. In one embodiment, the disclosed system for sequencing polynucleotides includes: a plurality of sequencing cells, each of the plurality of sequencing cells comprising a nanopore for sensing a polynucleotide; a plurality of electronic circuits, each of the plurality of electronic circuits associated with one of the plurality of sequencing cells; and at least one voltage source operably connected to at least one shift register, the output terminals of the at least one shift register operably connected to the plurality of electronic circuits.