公开(公告)号：US20240009665A1

公开(公告)日：2024-01-11

申请号：US18003281

申请日：2022-02-01

Applicant: Illumina, Inc.

Inventor： Ravi BILLA ,  John WALKER ,  Arvin EMADI ,  Jon ADAY ,  Tara BOZORG-GRAYELI ,  Ludovic VINCENT ,  Hai TRAN ,  Sanket RATHORE

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L2300/0645 ,  B01L2200/0647 ,  B01L2300/0887 ,  B01L2300/0819

Abstract: Provided herein include various examples of a flow cell and methods for forming aspects of flow cell. The method may include applying a first adhesive to a substrate. The method may include orienting a die on the first adhesive. The method may also include orienting a package on the first adhesive. The package includes a die and a top surface of the die comprises an active surface and electrical contact points. Surfaces adjacent to the active surface on at least two opposing sides of the active surface form fanout regions for utilization in a fluidic path of the flow cell. The method further may include applying a second adhesive to a part of the package and attaching a lid to the second adhesive to define a fluidic flow-cell cavity below the lid and above a surface comprising the active surface and the fanout regions.

公开(公告)号：US20230333017A1

公开(公告)日：2023-10-19

申请号：US18297891

申请日：2023-04-10

Applicant: ILLUMINA, INC.

Inventor： Tara BOZORG-GRAYELI ,  Ravi BILLA ,  Tracy FUNG ,  Mohsen REZAEI ,  Craig Hetherington ,  Paul Sangiorgio ,  Craig Ciesia ,  Arvin Emadi

IPC: G01N21/64 ,  H01L27/146

CPC classification number: G01N21/6428 ,  H01L27/14623 ,  G01N21/6454 ,  H01L27/14689

Abstract: Provided herein are various examples of aspects of a biosensor and methods for manufacturing and using aspects of a biosensor. The method of manufacturing may include forming a germanium layer above a surface of an image sensor and forming a dielectric stack above a surface of the germanium layer. The biosensor can be utilized by placing nucleic acid(s) in reaction sites of the biosensor, exposing the reaction sites to light from a light source (e.g., excitation light), receiving emitted light from the reaction sites via the germanium layer, and identifying, based on the emitted light, a composition of the one or more nucleic acids.