公开(公告)号：US11753685B2

公开(公告)日：2023-09-12

申请号：US16953480

申请日：2020-11-20

Applicant: ILLUMINA, INC.

Inventor： Sarah E. Shultzaberger ,  Fiona Kaper ,  Sarah Kinnings ,  Suzanne Rohrback ,  Carlo Randise-Hinchliff

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6883 ,  C12N15/10

CPC classification number: C12Q1/6883 ,  C12N15/1096 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.

公开(公告)号：US20230392207A1

公开(公告)日：2023-12-07

申请号：US18203734

申请日：2023-05-31

Applicant: ILLUMINA, INC.

Inventor： Sarah E. Shultzaberger ,  Suzanne Rohrback ,  Carlo Randise-Hinchliff

IPC: C12Q1/6883 ,  C12Q1/6806

CPC classification number: C12Q1/6883 ,  C12Q1/6806 ,  C12Q2600/158

Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women circulating RNA (C-RNA) molecules associated with preeclampsia.

公开(公告)号：US20210155987A1

公开(公告)日：2021-05-27

申请号：US16953480

申请日：2020-11-20

Applicant: ILLUMINA, INC.

Inventor： Sarah E. Shultzaberger ,  Fiona Kaper ,  Sarah Kinnings ,  Suzanne Rohrback ,  Carlo Randise-Hinchliff

IPC: C12Q1/6883 ,  C12N15/10

Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.

公开(公告)号：US20240127906A1

公开(公告)日：2024-04-18

申请号：US18484268

申请日：2023-10-10

Applicant: Illumina, Inc. ,  Illumina Cambridge Limited ,  Illumina Singapore PTE. LTD.

Inventor： Qi Wang ,  Suzanne Rohrback ,  Sarah Shultzaberger ,  Rebekah Karadeema ,  Leslie Beh Yee Ming ,  James Baye ,  Colin Brown

IPC: G16B30/10 ,  G16B20/20

CPC classification number: G16B30/10 ,  G16B20/20

Abstract: This disclosure describes methods, non-transitory computer readable media, and systems that can use a computationally efficient model to determine a corrected methylation-level value for a specific sample nucleotide sequence. For instance, the disclosed systems determine a false positive rate and a false negative rate at which a given methylation sequencing assay converts cytosine bases. Based on the determined false positive rate and false negative rate, the disclosed systems determine a corrected methylation-level value that corrects for a bias of the given methylation sequencing assay.

公开(公告)号：US20230313271A1

公开(公告)日：2023-10-05

申请号：US18172821

申请日：2023-02-22

Applicant: Illumina, Inc. ,  Illumina Cambridge Limited

Inventor： Steven Norberg ,  Luis Fernando Camarillo Guerrero ,  Colin Brown ,  Andrea Manzo ,  Sarah E. Shultzaberger ,  Michael Eberle ,  Sepideh Almasi ,  Suzanne Rohrback ,  Pascale Mathonet ,  Egor Dolzhenko

IPC: C12Q1/6809 ,  G16C20/70

CPC classification number: C12Q1/6809 ,  G16C20/70

Abstract: This disclosure describes methods, non-transitory computer readable media, and systems that can use a machine-learning to determine factors or scores indicating an error level with which a given methylation assay detects methylation of cytosine bases. For instance, the disclosed systems use a machine-learning model to generate a bias score indicating a degree to which a given methylation assay errs in detecting cytosine methylation when specific sequence contexts surround such cytosines compared to other sequence contexts. The machine-learning model may take various forms of models, including a decision-tree model, a neural network, or a combination of a decision-tree model and a neural network. In some cases, the disclosed system combines or uses bias scores from multiple machine-learning models to generate a consensus bias score.

公开(公告)号：US20230135486A1

公开(公告)日：2023-05-04

申请号：US18091186

申请日：2022-12-29

Applicant: ILLUMINA, INC.

Inventor： Sarah E. Shultzaberger ,  Fiona Kaper ,  Sarah Kinnings ,  Suzanne Rohrback ,  Carlo Randise-Hinchliff

IPC: C12Q1/6883 ,  C12N15/10

Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.