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公开(公告)号：US20210155987A1
公开(公告)日：2021-05-27
申请号：US16953480
申请日：2020-11-20
Applicant: ILLUMINA, INC.
Inventor： Sarah E. Shultzaberger , Fiona Kaper , Sarah Kinnings , Suzanne Rohrback , Carlo Randise-Hinchliff
IPC: C12Q1/6883 , C12N15/10
Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.
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公开(公告)号：US20250115900A1
公开(公告)日：2025-04-10
申请号：US18948276
申请日：2024-11-14
Applicant: ILLUMINA, INC.
Inventor： Dan Cao , Jeffrey S. Fisher , Fiona Kaper , Tarun Khurana , Tong Liu , Burak Okumus , Victor Quijano , Clifford Lee Wang , Yir-Shyuan Wu , Shi Min Xiao , Hongxia Xu
IPC: C12N15/10
Abstract: An example of a biotin-streptavidin cleavage composition includes a formamide reagent and a salt buffer. The formamide reagent is present in the biotin-streptavidin cleavage composition in an amount ranging from about 10% to about 50%, based on a total volume of the biotin-streptavidin cleavage composition. The salt buffer makes up the balance of the biotin-streptavidin cleavage composition. In some examples, the biotin-streptavidin cleavage composition is used to cleave library fragments from a solid support. In other examples, other mechanisms are used to cleave library fragments from a solid support.
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公开(公告)号：US11753685B2
公开(公告)日：2023-09-12
申请号：US16953480
申请日：2020-11-20
Applicant: ILLUMINA, INC.
Inventor： Sarah E. Shultzaberger , Fiona Kaper , Sarah Kinnings , Suzanne Rohrback , Carlo Randise-Hinchliff
IPC: C12Q1/68 , C12P19/34 , C12Q1/6883 , C12N15/10
CPC classification number: C12Q1/6883 , C12N15/1096 , C12Q2600/118 , C12Q2600/158
Abstract: The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.
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公开(公告)号：US20230183682A1
公开(公告)日：2023-06-15
申请号：US18163405
申请日：2023-02-02
Applicant: Illumina, Inc. , Illumina Cambridge Limited
Inventor： Niall Anthony Gormley , Andrew B. Kennedy , Robert Scott Kuersten , Gary Schroth , Carlo Randise-Hinchliff , Sarah E. Shultzaberger , Fiona Kaper , Yir-Shyuan Wu , Tarun Khurana , Foad Mashayekhi
IPC: C12N15/10
CPC classification number: C12N15/1065
Abstract: This application describes methods of preparing an immobilized library of tagged RNA fragments. Also described herein are a number of methods of preparing DNA and RNA sequencing libraries from a single sample. These methods can include library preparation from single cells.
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公开(公告)号：US20210198659A1
公开(公告)日：2021-07-01
申请号：US17197836
申请日：2021-03-10
Applicant: Illumina, Inc.
Inventor： Neeraj Salathia , Jian-Bing Fan , Fiona Kaper , Gordon M. Cann , Arash Jamshidi , Alex Aravanis
IPC: C12N15/10 , C12Q1/6869 , C12Q1/6853 , C12Q1/6806
Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
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Patent Agency Ranking
公开(公告)号：US20180355349A1
公开(公告)日：2018-12-13
申请号：US16021886
申请日：2018-06-28
Applicant: Illumina, Inc.
Inventor： Fiona Kaper , Gordon Cann
IPC: C12N15/10
CPC classification number: C12N15/1065 , C12N15/1003 , C12N15/1093
Abstract: A method of preparing a library of tagged nucleic acid fragments including contacting a population of cells directly with a lysis reagent having one or more protease to generate a cell lysate; inactivating the protease to generate an inactivated cell lysate, and applying a transposase and a transposon end composition containing a transferred strand to the inactivated cell lysate under conditions wherein the target nucleic acid and the transposon end composition undergo a transposition reaction.
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公开(公告)号：US20160098518A1
公开(公告)日：2016-04-07
申请号：US14878830
申请日：2015-10-08
Applicant: Illumina, Inc.
Inventor： Thomas Royce , Craig April , Fiona Kaper , Jian-Bing Fan
CPC classification number: G06F19/22 , C12Q1/6827 , C12Q1/6853 , C12Q1/6874 , C12Q1/6881 , C12Q1/6883 , C12Q2600/172 , G06F19/16 , C12Q2525/155 , C12Q2525/161 , C12Q2535/122
Abstract: Presented herein are methods and compositions for determining haplotypes in a sample. The methods are useful for obtaining sequence information regarding, for example, HLA type and haplotype. Also presented herein are methods of determining haplotypes in a sample based on a plurality sequence reads.
Abstract translation: 本文提出了用于确定样品中单倍型的方法和组合物。 该方法对于获得关于例如HLA类型和单体型的序列信息是有用的。 本文还呈现了基于多个序列读取来确定样品中的单倍型的方法。
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公开(公告)号：US11085041B2
公开(公告)日：2021-08-10
申请号：US16021886
申请日：2018-06-28
Applicant: Illumina, Inc.
Inventor： Fiona Kaper , Gordon Cann
IPC: C12N15/10 , C12Q1/6806
Abstract: A method of preparing a library of tagged nucleic acid fragments including contacting a population of cells directly with a lysis reagent having one or more protease to generate a cell lysate; inactivating the protease to generate an inactivated cell lysate, and applying a transposase and a transposon end composition containing a transferred strand to the inactivated cell lysate under conditions wherein the target nucleic acid and the transposon end composition undergo a transposition reaction.
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公开(公告)号：US20210238589A1
公开(公告)日：2021-08-05
申请号：US17166906
申请日：2021-02-03
Applicant: ILLUMINA, INC.
Inventor： Dan Cao , Jeffrey S. Fisher , Fiona Kaper , Tarun Kumar Khurana , Tong Liu , Burak Okumus , Victor J. Quijano , Clifford Lee Wang , Yir-Shyuan Wu , Shi Min Xiao , Hongxia Xu
IPC: C12N15/10
Abstract: An example of a biotin-streptavidin cleavage composition includes a formamide reagent and a salt buffer. The formamide reagent is present in the biotin-streptavidin cleavage composition in an amount ranging from about 10% to about 50%, based on a total volume of the biotin-streptavidin cleavage composition. The salt buffer makes up the balance of the biotin-streptavidin cleavage composition. In some examples, the biotin-streptavidin cleavage composition is used to cleave library fragments from a solid support. In other examples, other mechanisms are used to cleave library fragments from a solid support.
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公开(公告)号：US09181583B2
公开(公告)日：2015-11-10
申请号：US13790112
申请日：2013-03-08
Applicant: Illumina, Inc.
Inventor： Thomas Royce , Craig April , Fiona Kaper , Jian-Bing Fan
CPC classification number: G06F19/22 , C12Q1/6827 , C12Q1/6853 , C12Q1/6874 , C12Q1/6881 , C12Q1/6883 , C12Q2600/172 , G06F19/16 , C12Q2525/155 , C12Q2525/161 , C12Q2535/122
Abstract: Presented herein are methods and compositions for determining haplotypes in a sample. The methods are useful for obtaining sequence information regarding, for example, HLA type and haplotype. Also presented herein are methods of determining haplotypes in a sample based on a plurality sequence reads.
Abstract translation: 本文提出了用于确定样品中单倍型的方法和组合物。 该方法对于获得关于例如HLA类型和单体型的序列信息是有用的。 本文还呈现了基于多个序列读取来确定样品中的单倍型的方法。
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